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OPENSEQ.org
YEGU - Uncharacterized protein YegU
UniProt: P76418 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14064
Length: 334 (327)
Sequences: 1386
Seq/Len: 4.24
YEGU
Paralog alert: 0.27 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
270_C 288_A 4.199 1.00
268_N 304_A 3.445 1.00
21_M 60_T 3.349 1.00
4_E 299_N 3.341 1.00
14_A 63_T 3.325 1.00
72_A 84_L 3.241 1.00
133_A 160_S 3.233 1.00
266_D 269_R 2.716 1.00
84_L 88_N 2.651 1.00
15_L 301_I 2.596 1.00
105_G 135_M 2.439 1.00
62_D 135_M 2.417 1.00
62_D 282_D 2.354 1.00
132_G 135_M 2.304 1.00
156_V 177_A 2.17 1.00
62_D 105_G 2.111 1.00
275_A 285_G 2.083 1.00
252_S 287_M 2.049 1.00
6_I 142_C 1.976 1.00
9_A 138_S 1.962 1.00
134_A 176_I 1.886 1.00
272_V 276_N 1.884 1.00
7_L 322_T 1.879 1.00
12_G 267_P 1.875 1.00
148_D 151_S 1.869 1.00
13_Q 286_A 1.863 1.00
135_M 283_T 1.843 1.00
85_I 89_I 1.835 1.00
135_M 282_D 1.827 1.00
10_L 70_A 1.756 0.99
4_E 298_V 1.739 0.99
61_D 282_D 1.717 0.99
61_D 135_M 1.713 0.99
62_D 283_T 1.702 0.99
160_S 173_A 1.702 0.99
72_A 88_N 1.7 0.99
303_P 307_A 1.698 0.99
71_D 88_N 1.69 0.99
131_N 283_T 1.674 0.99
103_V 130_T 1.655 0.99
152_F 178_W 1.655 0.99
62_D 280_D 1.649 0.99
129_V 248_S 1.649 0.99
105_G 282_D 1.641 0.99
11_Y 298_V 1.604 0.99
105_G 132_G 1.598 0.99
24_E 61_D 1.598 0.99
141_G 177_A 1.578 0.99
154_D 158_L 1.563 0.98
13_Q 66_A 1.562 0.98
75_E 88_N 1.553 0.98
274_C 284_I 1.547 0.98
135_M 280_D 1.54 0.98
13_Q 138_S 1.539 0.98
61_D 132_G 1.531 0.98
157_A 161_S 1.517 0.98
19_M 271_A 1.498 0.98
105_G 131_N 1.49 0.98
180_I 290_A 1.478 0.98
62_D 132_G 1.476 0.98
15_L 267_P 1.475 0.98
138_S 290_A 1.464 0.97
24_E 62_D 1.461 0.97
27_P 30_R 1.455 0.97
264_Q 296_H 1.448 0.97
280_D 283_T 1.446 0.97
176_I 290_A 1.445 0.97
129_V 166_S 1.44 0.97
134_A 253_V 1.433 0.97
3_T 322_T 1.418 0.97
8_G 12_G 1.416 0.97
141_G 181_S 1.412 0.97
8_G 293_G 1.407 0.96
172_G 249_T 1.405 0.96
55_N 58_E 1.404 0.96
61_D 283_T 1.4 0.96
9_A 294_A 1.392 0.96
261_E 295_L 1.368 0.96
40_R 272_V 1.366 0.96
267_P 271_A 1.36 0.95
312_V 318_N 1.348 0.95
90_L 112_L 1.345 0.95
264_Q 270_C 1.335 0.95
134_A 172_G 1.331 0.95
292_C 296_H 1.328 0.95
246_G 251_E 1.325 0.95
157_A 174_V 1.32 0.94
319_R 323_A 1.317 0.94
24_E 282_D 1.314 0.94
40_R 304_A 1.306 0.94
131_N 135_M 1.305 0.94
270_C 292_C 1.299 0.94
141_G 180_I 1.294 0.94
297_G 300_A 1.288 0.93
137_V 177_A 1.274 0.93
85_I 162_P 1.272 0.93
8_G 297_G 1.262 0.93
69_L 89_I 1.259 0.92
70_A 324_L 1.254 0.92
62_D 131_N 1.252 0.92
24_E 280_D 1.247 0.92
105_G 280_D 1.237 0.92
132_G 283_T 1.237 0.92
66_A 139_P 1.237 0.92
76_R 81_D 1.229 0.91
61_D 105_G 1.226 0.91
156_V 174_V 1.226 0.91
132_G 282_D 1.224 0.91
65_M 89_I 1.219 0.91
293_G 297_G 1.218 0.91
95_R 116_R 1.203 0.90
71_D 316_D 1.197 0.90
105_G 136_R 1.197 0.90
20_G 24_E 1.192 0.89
289_T 293_G 1.188 0.89
267_P 301_I 1.187 0.89
180_I 294_A 1.174 0.88
189_W 261_E 1.173 0.88
142_C 180_I 1.172 0.88
141_G 184_I 1.168 0.88
131_N 282_D 1.164 0.88
168_L 248_S 1.161 0.88
169_A 249_T 1.152 0.87
102_N 130_T 1.15 0.87
59_F 64_S 1.149 0.87
133_A 249_T 1.148 0.87
144_L 155_D 1.148 0.87
140_L 159_A 1.144 0.87
24_E 135_M 1.143 0.87
5_R 8_G 1.142 0.87
131_N 252_S 1.139 0.86
134_A 173_A 1.137 0.86
144_L 152_F 1.125 0.85
13_Q 290_A 1.122 0.85
24_E 132_G 1.112 0.85
25_L 103_V 1.107 0.84
268_N 305_L 1.102 0.84
133_A 173_A 1.097 0.83
23_S 276_N 1.095 0.83
105_G 283_T 1.083 0.82
25_L 106_P 1.081 0.82
152_F 156_V 1.081 0.82
137_V 159_A 1.08 0.82
132_G 280_D 1.076 0.82
61_D 280_D 1.075 0.82
182_R 187_E 1.066 0.81
10_L 321_A 1.064 0.81
105_G 130_T 1.059 0.80
11_Y 306_K 1.057 0.80
170_V 174_V 1.057 0.80
151_S 154_D 1.052 0.80
255_C 284_I 1.051 0.80
244_G 284_I 1.048 0.79
65_M 112_L 1.048 0.79
104_L 108_S 1.048 0.79
166_S 169_A 1.041 0.79
137_V 173_A 1.041 0.79
183_A 294_A 1.039 0.79
153_I 174_V 1.034 0.78
24_E 283_T 1.032 0.78
172_G 253_V 1.029 0.78
61_D 131_N 1.026 0.77
76_R 84_L 1.026 0.77
25_L 105_G 1.02 0.77
244_G 251_E 1.018 0.77
65_M 130_T 1.011 0.76
132_G 164_H 1.011 0.76
161_S 170_V 1.006 0.75
103_V 129_V 1 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1t5jA10.90421000.164Contact Map0.618
2fozA10.95511000.187Contact Map0.656
3o5tA10.86831000.206Contact Map0.638
2woeA30.86231000.207Contact Map0.682
2yzvA10.87721000.229Contact Map0.766
3hfwA10.95811000.243Contact Map0.608
4ayoA10.383212.20.964Contact Map0.229
3ov9A30.278410.20.965Contact Map0.128
4j4wA10.27849.90.965Contact Map0.219
4j4rA10.27849.10.966Contact Map0.202
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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