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OPENSEQ.org
YEGS - Lipid kinase YegS
UniProt: P76407 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14367
Length: 299 (290)
Sequences: 2863
Seq/Len: 9.87
YEGS
Paralog alert: 0.41 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
127_A 135_F 4.139 1.00
257_D 279_H 3.818 1.00
183_R 257_D 3.738 1.00
255_W 279_H 3.531 1.00
255_W 281_E 3.51 1.00
128_Q 281_E 3.418 1.00
181_E 259_Q 3.141 1.00
181_E 190_Q 2.813 1.00
63_A 73_V 2.729 1.00
253_S 256_F 2.717 1.00
222_Q 252_A 2.645 1.00
42_E 45_D 2.529 1.00
128_Q 283_L 2.483 1.00
184_G 253_S 2.458 1.00
123_A 288_R 2.283 1.00
139_A 280_I 2.264 1.00
125_D 219_G 2.227 1.00
220_L 254_S 2.155 1.00
25_I 29_R 2.137 1.00
103_V 289_C 2.087 1.00
223_L 256_F 2.086 1.00
64_G 93_L 2.041 1.00
199_G 211_C 2.019 1.00
78_I 126_M 1.983 1.00
40_T 46_A 1.954 1.00
127_A 221_L 1.95 1.00
183_R 259_Q 1.947 1.00
44_G 72_E 1.92 1.00
99_F 124_I 1.91 1.00
140_T 267_N 1.906 1.00
91_L 109_L 1.889 1.00
106_P 115_L 1.876 1.00
227_T 249_I 1.869 1.00
72_E 76_A 1.855 1.00
125_D 218_D 1.831 1.00
45_D 48_R 1.825 1.00
98_D 137_N 1.817 1.00
45_D 49_Y 1.806 1.00
121_A 288_R 1.792 1.00
220_L 252_A 1.753 1.00
140_T 144_G 1.743 1.00
46_A 72_E 1.711 1.00
27_L 114_K 1.704 1.00
40_T 72_E 1.691 1.00
185_E 254_S 1.687 1.00
50_V 54_R 1.685 1.00
122_I 217_N 1.671 1.00
144_G 267_N 1.601 1.00
223_L 253_S 1.583 1.00
198_I 221_L 1.523 1.00
98_D 206_G 1.504 1.00
183_R 188_H 1.494 1.00
8_L 58_V 1.486 1.00
283_L 286_A 1.485 1.00
7_S 60_T 1.476 1.00
259_Q 277_N 1.475 1.00
198_I 256_F 1.46 1.00
225_I 251_G 1.453 1.00
126_M 286_A 1.436 1.00
7_S 62_I 1.432 1.00
150_E 171_R 1.397 0.99
6_A 59_A 1.393 0.99
143_F 147_I 1.381 0.99
218_D 222_Q 1.362 0.99
148_T 267_N 1.359 0.99
193_A 225_I 1.355 0.99
108_A 111_K 1.344 0.99
138_M 197_G 1.336 0.99
98_D 207_G 1.331 0.99
48_R 52_E 1.326 0.99
46_A 50_V 1.323 0.99
106_P 112_A 1.314 0.99
257_D 277_N 1.299 0.99
61_V 77_L 1.295 0.99
6_A 34_T 1.273 0.99
186_N 255_W 1.269 0.99
105_I 112_A 1.263 0.99
214_A 222_Q 1.243 0.98
50_V 73_V 1.242 0.98
12_N 15_S 1.24 0.98
70_I 90_I 1.231 0.98
51_E 79_Q 1.217 0.98
128_Q 131_K 1.216 0.98
75_T 134_C 1.214 0.98
41_W 45_D 1.206 0.98
200_N 222_Q 1.205 0.98
74_S 287_L 1.202 0.98
179_R 190_Q 1.201 0.98
106_P 111_K 1.195 0.98
198_I 280_I 1.189 0.98
223_L 251_G 1.184 0.98
71_N 75_T 1.183 0.98
10_I 50_V 1.18 0.98
98_D 205_G 1.175 0.98
99_F 103_V 1.172 0.97
42_E 72_E 1.167 0.97
179_R 192_D 1.162 0.97
111_K 114_K 1.159 0.97
181_E 188_H 1.158 0.97
128_Q 134_C 1.156 0.97
260_A 276_Q 1.151 0.97
27_L 113_L 1.144 0.97
144_G 204_A 1.133 0.97
221_L 282_I 1.133 0.97
32_G 64_G 1.131 0.97
116_A 290_R 1.129 0.97
63_A 69_T 1.128 0.97
121_A 290_R 1.125 0.97
254_S 284_P 1.117 0.96
9_L 62_I 1.102 0.96
99_F 137_N 1.1 0.96
98_D 148_T 1.098 0.96
50_V 53_A 1.098 0.96
102_S 202_R 1.096 0.96
23_E 110_D 1.095 0.96
184_G 256_F 1.091 0.96
63_A 88_L 1.088 0.96
40_T 45_D 1.086 0.96
137_N 267_N 1.081 0.95
156_K 163_S 1.078 0.95
74_S 136_I 1.075 0.95
211_C 214_A 1.074 0.95
265_T 272_P 1.071 0.95
116_A 119_G 1.06 0.95
218_D 252_A 1.057 0.95
138_M 199_G 1.049 0.94
46_A 76_A 1.048 0.94
196_I 225_I 1.035 0.94
99_F 136_I 1.033 0.94
99_F 200_N 1.03 0.94
13_G 40_T 1.028 0.93
180_C 193_A 1.027 0.93
60_T 290_R 1.025 0.93
137_N 201_G 1.024 0.93
110_D 113_L 1.019 0.93
119_G 290_R 1.018 0.93
126_M 136_I 1.013 0.93
159_L 166_I 1.009 0.93
198_I 223_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2bonA211000.133Contact Map0.773
2qv7A10.991000.17Contact Map0.783
3vzbA30.96991000.178Contact Map0.693
3s40A40.98331000.188Contact Map0.837
1u0tA20.84621000.551Contact Map0.507
2an1A40.84621000.562Contact Map0.567
2i2cA10.8061000.574Contact Map0.447
1z0sA40.76251000.581Contact Map0.507
1yt5A40.76591000.595Contact Map0.558
3afoA20.862998.60.845Contact Map0.459
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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