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OPENSEQ.org
MTFA - Protein MtfA
UniProt: P76346 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13377
Length: 265 (247)
Sequences: 341
Seq/Len: 1.38
MTFA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
58_F 64_R 3.566 1.00
217_S 242_Y 3.305 1.00
68_I 92_I 2.753 1.00
46_F 73_C 2.547 1.00
54_P 60_L 2.527 1.00
60_L 64_R 2.265 0.99
147_I 217_S 2.131 0.99
32_T 35_E 2.05 0.98
61_D 64_R 1.93 0.97
62_S 65_S 1.916 0.97
201_I 216_L 1.824 0.95
151_A 213_F 1.799 0.95
151_A 242_Y 1.691 0.92
34_Q 37_S 1.681 0.92
83_W 241_F 1.666 0.91
95_A 132_L 1.66 0.91
97_F 117_Q 1.565 0.88
235_W 245_D 1.562 0.87
228_A 247_L 1.562 0.87
220_F 235_W 1.561 0.87
6_W 9_Q 1.507 0.85
234_L 237_R 1.481 0.83
43_A 70_L 1.47 0.83
62_S 66_C 1.468 0.83
184_M 188_Q 1.442 0.81
75_P 147_I 1.436 0.81
79_L 244_Q 1.435 0.81
53_V 89_E 1.427 0.80
180_L 238_F 1.417 0.80
155_D 176_W 1.412 0.79
71_L 84_L 1.391 0.78
188_Q 191_I 1.385 0.77
91_L 99_V 1.384 0.77
99_V 117_Q 1.376 0.77
97_F 128_V 1.37 0.76
64_R 131_W 1.359 0.75
183_A 231_F 1.355 0.75
54_P 150_V 1.353 0.75
38_K 78_E 1.352 0.75
65_S 93_Y 1.325 0.73
205_A 219_Y 1.316 0.72
130_N 133_D 1.314 0.72
126_P 153_K 1.3 0.71
105_D 111_H 1.273 0.68
55_L 91_L 1.27 0.68
60_L 85_D 1.264 0.68
86_G 153_K 1.255 0.67
93_Y 97_F 1.252 0.67
215_V 218_E 1.237 0.65
227_F 235_W 1.236 0.65
4_W 9_Q 1.234 0.65
62_S 205_A 1.226 0.64
70_L 136_D 1.225 0.64
213_F 245_D 1.214 0.63
183_A 234_L 1.21 0.63
187_I 227_F 1.19 0.61
84_L 150_V 1.185 0.60
75_P 80_G 1.184 0.60
156_T 162_A 1.177 0.60
219_Y 223_A 1.175 0.59
17_L 40_V 1.163 0.58
58_F 131_W 1.162 0.58
23_L 36_Q 1.158 0.58
178_H 182_A 1.155 0.57
64_R 95_A 1.153 0.57
60_L 92_I 1.143 0.56
47_L 134_I 1.142 0.56
35_E 205_A 1.132 0.55
93_Y 128_V 1.131 0.55
72_F 84_L 1.12 0.54
91_L 171_R 1.118 0.54
46_F 128_V 1.116 0.53
122_W 128_V 1.112 0.53
9_Q 12_A 1.111 0.53
186_N 231_F 1.1 0.52
17_L 44_E 1.079 0.50
244_Q 249_R 1.074 0.49
38_K 51_R 1.068 0.49
45_R 243_Q 1.067 0.49
153_K 156_T 1.066 0.48
42_L 73_C 1.066 0.48
220_F 245_D 1.062 0.48
58_F 61_D 1.059 0.48
235_W 244_Q 1.053 0.47
109_L 202_D 1.049 0.47
220_F 246_P 1.045 0.46
37_S 40_V 1.044 0.46
41_T 225_E 1.042 0.46
11_S 16_A 1.04 0.46
36_Q 66_C 1.039 0.46
7_K 23_L 1.038 0.46
213_F 242_Y 1.037 0.46
155_D 166_P 1.036 0.45
89_E 99_V 1.033 0.45
96_P 143_F 1.032 0.45
167_F 170_L 1.026 0.44
42_L 80_G 1.025 0.44
145_L 163_S 1.024 0.44
184_M 187_I 1.021 0.44
164_G 176_W 1.021 0.44
172_E 235_W 1.02 0.44
225_E 233_S 1.02 0.44
43_A 69_A 1.018 0.44
35_E 78_E 1.017 0.44
69_A 129_L 1.015 0.43
220_F 227_F 1.014 0.43
70_L 147_I 1.008 0.43
121_S 201_I 1.008 0.43
87_F 153_K 1.007 0.43
191_I 203_A 1.006 0.42
68_I 90_V 1.003 0.42
27_L 89_E 1.002 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3khiA10.98111000.098Contact Map0.579
1j7nA20.754799.90.748Contact Map0.457
4dv8A10.743499.90.76Contact Map0.36
4jiuA10.369870.40.957Contact Map0.161
4jixA20.377451.40.962Contact Map0.229
1ug7A10.392526.60.967Contact Map0.247
2ixmA10.622616.20.97Contact Map0.105
2ixnA20.607512.70.972Contact Map0.163
2ixoA20.656612.40.972Contact Map0.174
2cpmA10.328310.40.973Contact Map0.137
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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