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OPENSEQ.org
YEDY - Sulfoxide reductase catalytic subunit YedY
UniProt: P76342 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14047
Length: 334 (328)
Sequences: 411
Seq/Len: 1.25
YEDY
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
144_M 249_G 3.93 1.00
15_E 227_K 3.867 1.00
121_A 169_E 3.652 1.00
119_E 171_T 3.398 1.00
184_A 187_Q 3.343 1.00
165_L 258_L 3.313 1.00
9_E 12_V 3.144 1.00
284_Y 313_L 2.826 1.00
221_T 240_I 2.825 1.00
137_L 222_V 2.761 1.00
117_S 255_S 2.755 1.00
264_P 268_N 2.635 1.00
84_V 224_V 2.631 1.00
200_L 270_A 2.602 1.00
93_F 188_M 2.59 1.00
119_E 173_N 2.514 1.00
117_S 257_K 2.467 1.00
119_E 260_R 2.269 0.99
116_I 126_L 2.181 0.99
114_L 237_V 2.15 0.98
7_L 11_D 2.138 0.98
110_D 128_H 2.095 0.98
104_A 107_L 2.059 0.98
178_A 264_P 1.968 0.97
182_I 187_Q 1.961 0.97
178_A 268_N 1.959 0.97
94_G 100_P 1.953 0.97
265_T 268_N 1.952 0.96
90_F 252_S 1.923 0.96
159_F 164_L 1.914 0.96
127_D 130_D 1.898 0.96
173_N 260_R 1.887 0.96
149_A 279_A 1.803 0.94
137_L 157_I 1.794 0.94
21_K 24_Q 1.77 0.93
151_S 297_F 1.768 0.93
81_A 227_K 1.738 0.92
121_A 171_T 1.705 0.91
135_F 159_F 1.68 0.90
183_Y 191_Q 1.648 0.89
108_K 187_Q 1.628 0.88
205_V 269_L 1.626 0.88
294_T 308_R 1.618 0.88
328_L 333_N 1.59 0.87
149_A 259_T 1.589 0.87
154_V 298_I 1.585 0.87
297_F 309_Q 1.584 0.87
136_P 168_A 1.542 0.85
176_Y 262_R 1.529 0.84
270_A 334_F 1.508 0.83
115_K 125_T 1.505 0.83
90_F 182_I 1.492 0.82
7_L 12_V 1.488 0.82
239_L 250_I 1.484 0.81
163_K 166_A 1.48 0.81
309_Q 312_L 1.461 0.80
172_S 210_L 1.46 0.80
258_L 293_A 1.447 0.79
115_K 255_S 1.432 0.78
162_H 166_A 1.414 0.77
177_V 258_L 1.4 0.76
180_E 257_K 1.392 0.75
210_L 258_L 1.387 0.75
313_L 320_Q 1.382 0.74
30_G 33_A 1.38 0.74
116_I 124_L 1.343 0.71
76_L 309_Q 1.337 0.71
221_T 239_L 1.336 0.71
318_A 322_A 1.327 0.70
215_H 318_A 1.301 0.68
200_L 249_G 1.295 0.67
165_L 214_M 1.292 0.67
179_F 256_I 1.29 0.67
104_A 109_T 1.28 0.66
131_L 222_V 1.277 0.66
210_L 324_L 1.275 0.66
215_H 218_T 1.274 0.66
264_P 269_L 1.27 0.65
96_D 331_R 1.261 0.64
88_N 298_I 1.256 0.64
273_D 279_A 1.235 0.62
215_H 324_L 1.234 0.62
120_V 293_A 1.23 0.62
115_K 119_E 1.23 0.62
8_K 11_D 1.213 0.60
85_S 233_N 1.21 0.60
178_A 257_K 1.201 0.59
151_S 154_V 1.201 0.59
18_F 299_G 1.195 0.58
124_L 168_A 1.19 0.58
78_L 224_V 1.182 0.57
191_Q 250_I 1.179 0.57
159_F 222_V 1.166 0.55
191_Q 279_A 1.16 0.55
216_P 219_L 1.158 0.55
154_V 297_F 1.151 0.54
94_G 190_G 1.146 0.53
134_R 167_L 1.139 0.53
110_D 127_D 1.132 0.52
323_S 326_R 1.128 0.52
76_L 297_F 1.127 0.52
80_P 84_V 1.123 0.51
120_V 258_L 1.117 0.51
294_T 298_I 1.114 0.50
165_L 177_V 1.113 0.50
113_T 129_D 1.11 0.50
72_W 215_H 1.109 0.50
113_T 127_D 1.105 0.49
168_A 258_L 1.104 0.49
218_T 241_V 1.096 0.49
8_K 12_V 1.095 0.48
80_P 83_K 1.094 0.48
108_K 184_A 1.091 0.48
221_T 237_V 1.079 0.47
160_P 168_A 1.079 0.47
163_K 167_L 1.077 0.47
136_P 163_K 1.076 0.47
39_P 334_F 1.073 0.46
110_D 129_D 1.07 0.46
157_I 222_V 1.069 0.46
300_S 309_Q 1.069 0.46
182_I 191_Q 1.064 0.45
116_I 168_A 1.064 0.45
209_R 216_P 1.061 0.45
200_L 334_F 1.059 0.45
45_D 48_S 1.049 0.44
182_I 188_M 1.047 0.44
12_V 141_I 1.046 0.44
195_F 270_A 1.043 0.43
131_L 219_L 1.043 0.43
211_D 216_P 1.036 0.43
262_R 333_N 1.035 0.43
299_G 308_R 1.03 0.42
224_V 240_I 1.028 0.42
180_E 255_S 1.028 0.42
159_F 237_V 1.023 0.41
101_A 314_F 1.018 0.41
313_L 318_A 1.016 0.41
98_A 102_A 1.013 0.41
297_F 300_S 1.012 0.40
103_N 189_P 1.011 0.40
111_P 114_L 1.008 0.40
78_L 84_V 1.008 0.40
95_L 332_E 1.006 0.40
276_G 285_V 1.005 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1xdyA100.86831000.494Contact Map0.549
2a9dA20.77251000.77Contact Map0.465
2xtsA20.79041000.772Contact Map0.547
2blfA10.81741000.773Contact Map0.47
1soxA20.90421000.778Contact Map0.462
1ogpA60.78441000.797Contact Map0.502
2bihA10.88621000.799Contact Map0.567
2biiA20.74851000.8Contact Map0.595
2pq4B10.104823.40.982Contact Map0.021
3bbzA20.089890.985Contact Map0.509
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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