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FLHB - Flagellar biosynthetic protein FlhB
UniProt: P76299 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14035
Length: 382 (374)
Sequences: 1024
Seq/Len: 2.74
FLHB
Paralog alert: 0.33 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
23_E 118_K 5.887 1.00
15_H 19_K 4.993 1.00
265_I 304_G 4.112 1.00
19_K 22_E 3.991 1.00
224_Q 228_D 3.945 1.00
128_N 131_P 3.528 1.00
217_K 220_R 3.469 1.00
215_H 219_L 3.313 1.00
12_P 216_L 3.144 1.00
17_L 216_L 3.108 1.00
14_P 18_E 2.93 1.00
13_T 226_I 2.907 1.00
222_S 225_D 2.818 1.00
243_I 247_Q 2.812 1.00
19_K 23_E 2.786 1.00
299_R 302_E 2.711 1.00
222_S 226_I 2.676 1.00
258_D 328_G 2.619 1.00
116_S 119_S 2.411 1.00
317_L 342_V 2.399 1.00
242_R 245_Q 2.36 1.00
144_E 147_K 2.163 1.00
10_E 223_R 2.139 1.00
40_V 102_V 2.031 1.00
298_L 301_R 2.017 1.00
265_I 300_I 1.967 0.99
214_S 218_K 1.962 0.99
20_A 219_L 1.955 0.99
279_D 282_K 1.944 0.99
22_E 118_K 1.942 0.99
272_Y 293_A 1.837 0.99
258_D 261_K 1.836 0.99
25_Q 215_H 1.818 0.99
289_V 309_V 1.802 0.99
303_I 307_N 1.752 0.98
139_A 217_K 1.745 0.98
15_H 233_S 1.739 0.98
140_Q 214_S 1.714 0.98
17_L 219_L 1.662 0.98
272_Y 294_G 1.642 0.97
166_H 169_Q 1.624 0.97
18_E 22_E 1.591 0.97
39_L 197_V 1.584 0.97
213_F 217_K 1.575 0.96
25_Q 218_K 1.547 0.96
259_V 309_V 1.538 0.96
272_Y 315_P 1.533 0.96
162_F 195_L 1.493 0.95
160_G 164_W 1.466 0.94
210_F 214_S 1.466 0.94
44_V 98_G 1.464 0.94
228_D 232_Q 1.446 0.93
267_N 313_E 1.442 0.93
143_A 210_F 1.44 0.93
17_L 215_H 1.439 0.93
208_V 212_I 1.43 0.93
301_R 305_A 1.425 0.93
136_M 145_L 1.419 0.93
28_R 107_P 1.409 0.92
28_R 111_G 1.391 0.92
261_K 277_Q 1.39 0.92
301_R 313_E 1.388 0.91
273_S 298_L 1.387 0.91
242_R 246_M 1.384 0.91
246_M 250_A 1.381 0.91
9_T 223_R 1.362 0.90
266_V 318_A 1.357 0.90
118_K 121_Q 1.351 0.90
260_P 307_N 1.349 0.90
19_K 118_K 1.326 0.89
131_P 134_K 1.323 0.89
273_S 301_R 1.319 0.88
284_S 330_Q 1.31 0.88
11_A 216_L 1.297 0.87
344_A 347_W 1.294 0.87
288_V 325_A 1.291 0.87
176_E 180_T 1.288 0.87
298_L 313_E 1.285 0.87
132_G 135_R 1.284 0.87
251_A 254_R 1.28 0.86
267_N 305_A 1.267 0.86
138_S 141_T 1.266 0.86
27_P 215_H 1.257 0.85
121_Q 125_S 1.253 0.85
8_K 16_R 1.25 0.85
125_S 131_P 1.238 0.84
100_V 103_A 1.236 0.84
312_L 345_W 1.231 0.83
335_L 343_L 1.226 0.83
262_A 289_V 1.219 0.82
42_V 193_A 1.219 0.82
15_H 18_E 1.215 0.82
298_L 305_A 1.214 0.82
275_A 292_G 1.212 0.82
239_V 242_R 1.207 0.82
260_P 303_I 1.184 0.80
292_G 300_I 1.181 0.80
316_P 320_A 1.18 0.80
92_L 96_I 1.176 0.79
230_F 234_E 1.171 0.79
299_R 303_I 1.169 0.79
116_S 120_L 1.161 0.78
296_V 327_I 1.161 0.78
314_A 341_E 1.16 0.78
158_V 199_G 1.159 0.78
36_L 109_M 1.157 0.78
294_G 319_R 1.157 0.78
55_R 87_E 1.152 0.77
274_V 315_P 1.149 0.77
275_A 290_A 1.138 0.76
223_R 226_I 1.115 0.74
139_A 220_R 1.114 0.74
271_H 294_G 1.113 0.74
367_P 370_E 1.111 0.74
270_T 319_R 1.111 0.74
41_G 99_V 1.111 0.74
259_V 300_I 1.107 0.73
32_L 208_V 1.103 0.73
283_M 287_K 1.1 0.73
277_Q 283_M 1.091 0.72
263_D 277_Q 1.091 0.72
17_L 20_A 1.084 0.71
173_L 283_M 1.081 0.71
16_R 232_Q 1.075 0.70
288_V 321_L 1.074 0.70
274_V 321_L 1.073 0.70
10_E 226_I 1.065 0.69
262_A 275_A 1.055 0.68
91_A 94_P 1.048 0.67
288_V 343_L 1.046 0.67
212_I 216_L 1.046 0.67
44_V 102_V 1.043 0.67
335_L 342_V 1.043 0.67
103_A 107_P 1.042 0.67
288_V 335_L 1.04 0.66
140_Q 218_K 1.04 0.66
143_A 146_L 1.034 0.66
216_L 219_L 1.033 0.66
12_P 31_E 1.032 0.65
368_V 374_F 1.032 0.65
256_M 296_V 1.031 0.65
266_V 310_P 1.031 0.65
370_E 373_D 1.03 0.65
21_R 215_H 1.027 0.65
255_M 299_R 1.02 0.64
16_R 19_K 1.016 0.64
83_L 87_E 1.014 0.63
346_V 349_L 1.013 0.63
215_H 218_K 1.011 0.63
345_W 349_L 1.009 0.63
268_N 271_H 1.002 0.62
98_G 206_F 1 0.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jljA10.3771000.538Contact Map0.576
3bzsA10.35861000.543Contact Map0.647
2jliA10.3221000.583Contact Map0.565
3t7yA20.25391000.692Contact Map0.534
3b0zB10.29841000.717Contact Map0.458
3c01E40.25651000.741Contact Map0.576
3b1sB30.22771000.743Contact Map0.528
3bzyB10.21731000.743Contact Map0.503
2vt1B10.24351000.748Contact Map0.432
3bzyA10.141499.90.822Contact Map1
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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