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OPENSEQ.org
INSQ - Putative transposase InsQ for insertion sequence element IS609
UniProt: P76102 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13756
Length: 382 (351)
Sequences: 1997
Seq/Len: 5.69
INSQ
Paralog alert: 0.60 [within 20: 0.09] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
228_D 232_K 5.333 1.00
250_K 253_N 4.789 1.00
169_L 287_M 3.323 1.00
295_Q 302_V 3.266 1.00
315_A 345_N 2.968 1.00
188_Q 277_R 2.741 1.00
286_E 290_Q 2.531 1.00
288_R 304_A 2.47 1.00
286_E 289_R 2.455 1.00
353_A 356_A 2.409 1.00
245_V 354_G 2.334 1.00
292_A 296_L 2.307 1.00
287_M 291_L 2.29 1.00
325_R 328_Q 2.27 1.00
305_V 350_I 2.225 1.00
312_Q 324_N 2.205 1.00
107_I 141_I 2.163 1.00
235_T 239_K 2.13 1.00
246_I 291_L 2.057 1.00
169_L 229_Y 1.999 1.00
331_F 340_A 1.989 1.00
242_A 300_G 1.964 1.00
3_R 53_D 1.95 1.00
238_S 295_Q 1.905 1.00
211_Q 215_I 1.889 1.00
57_Q 96_Q 1.88 1.00
65_D 93_R 1.87 1.00
273_S 276_N 1.865 1.00
16_L 66_L 1.861 1.00
246_I 302_V 1.852 1.00
194_L 211_Q 1.806 1.00
209_Q 212_K 1.803 1.00
333_C 336_C 1.801 1.00
231_H 293_Y 1.783 1.00
57_Q 95_P 1.763 1.00
17_A 21_E 1.757 1.00
313_R 320_T 1.753 1.00
15_A 63_L 1.737 1.00
206_N 209_Q 1.736 1.00
234_T 290_Q 1.728 1.00
326_L 329_S 1.721 1.00
138_K 220_S 1.713 1.00
329_S 342_A 1.685 1.00
10_F 50_W 1.664 1.00
76_K 79_A 1.66 1.00
37_S 40_V 1.648 1.00
128_K 146_E 1.646 1.00
314_C 317_C 1.63 0.99
187_N 222_I 1.617 0.99
20_N 80_F 1.614 0.99
230_L 290_Q 1.604 0.99
198_L 212_K 1.579 0.99
244_I 295_Q 1.573 0.99
272_K 276_N 1.56 0.99
332_R 339_T 1.553 0.99
231_H 290_Q 1.553 0.99
316_Y 338_Y 1.547 0.99
194_L 215_I 1.542 0.99
191_L 215_I 1.537 0.99
317_C 333_C 1.534 0.99
187_N 225_I 1.533 0.99
33_G 36_A 1.528 0.99
279_I 284_W 1.508 0.99
191_L 219_H 1.504 0.99
160_V 172_L 1.503 0.99
292_A 304_A 1.502 0.99
231_H 294_K 1.493 0.99
317_C 336_C 1.493 0.99
314_C 333_C 1.491 0.99
130_V 141_I 1.49 0.99
319_H 334_Q 1.486 0.99
32_Y 36_A 1.474 0.99
5_A 139_W 1.461 0.99
201_K 211_Q 1.458 0.99
312_Q 322_K 1.455 0.99
67_E 71_K 1.453 0.99
325_R 329_S 1.438 0.98
194_L 218_L 1.437 0.98
310_T 350_I 1.398 0.98
251_V 285_Y 1.394 0.98
1_M 139_W 1.384 0.98
246_I 288_R 1.383 0.98
171_T 344_V 1.383 0.98
172_L 176_T 1.37 0.98
231_H 234_T 1.37 0.98
156_S 242_A 1.369 0.98
331_F 338_Y 1.362 0.98
198_L 215_I 1.358 0.97
345_N 349_N 1.351 0.97
352_A 357_V 1.348 0.97
109_L 132_V 1.348 0.97
290_Q 293_Y 1.336 0.97
234_T 293_Y 1.335 0.97
314_C 336_C 1.324 0.97
162_L 170_A 1.313 0.97
36_A 63_L 1.3 0.96
250_K 307_P 1.292 0.96
248_D 304_A 1.292 0.96
330_K 339_T 1.273 0.96
348_R 352_A 1.258 0.96
324_N 328_Q 1.256 0.95
32_Y 64_K 1.249 0.95
70_Y 80_F 1.247 0.95
321_A 324_N 1.244 0.95
72_N 77_R 1.241 0.95
246_I 304_A 1.231 0.95
168_K 171_T 1.23 0.95
307_P 310_T 1.226 0.95
23_H 74_F 1.219 0.94
230_L 234_T 1.218 0.94
346_G 349_N 1.215 0.94
230_L 286_E 1.207 0.94
234_T 294_K 1.204 0.94
325_R 342_A 1.191 0.93
198_L 211_Q 1.19 0.93
51_L 59_L 1.187 0.93
33_G 37_S 1.187 0.93
270_R 280_L 1.185 0.93
340_A 344_V 1.177 0.93
106_R 114_W 1.17 0.93
230_L 283_G 1.167 0.93
164_A 284_W 1.164 0.92
32_Y 63_L 1.161 0.92
197_Q 201_K 1.159 0.92
204_F 208_W 1.158 0.92
34_K 37_S 1.147 0.92
245_V 350_I 1.142 0.91
315_A 348_R 1.142 0.91
39_L 43_K 1.139 0.91
32_Y 35_M 1.139 0.91
207_N 210_K 1.135 0.91
39_L 63_L 1.131 0.91
136_C 220_S 1.13 0.91
26_G 29_Y 1.13 0.91
235_T 298_R 1.128 0.91
330_K 340_A 1.126 0.91
195_Q 219_H 1.123 0.91
220_S 224_N 1.123 0.91
344_V 347_A 1.117 0.90
20_N 24_E 1.116 0.90
183_S 225_I 1.115 0.90
227_R 286_E 1.113 0.90
159_M 351_L 1.108 0.90
15_A 66_L 1.108 0.90
36_A 64_K 1.096 0.89
223_A 227_R 1.095 0.89
68_R 72_N 1.094 0.89
30_I 35_M 1.094 0.89
326_L 342_A 1.092 0.89
291_L 302_V 1.081 0.88
253_N 279_I 1.08 0.88
6_G 9_R 1.08 0.88
255_S 280_L 1.073 0.88
160_V 173_S 1.073 0.88
342_A 346_G 1.072 0.88
11_V 59_L 1.071 0.88
194_L 197_Q 1.063 0.87
359_A 363_M 1.058 0.87
253_N 307_P 1.057 0.87
43_K 59_L 1.052 0.86
166_V 282_Q 1.052 0.86
19_Q 35_M 1.05 0.86
176_T 236_A 1.044 0.86
324_N 342_A 1.043 0.86
238_S 298_R 1.04 0.85
315_A 338_Y 1.04 0.85
8_C 62_S 1.036 0.85
19_Q 67_E 1.034 0.85
180_P 282_Q 1.031 0.85
192_A 196_R 1.031 0.85
72_N 75_R 1.026 0.84
247_E 307_P 1.026 0.84
309_Y 312_Q 1.016 0.84
195_Q 215_I 1.014 0.83
321_A 331_F 1.013 0.83
135_S 220_S 1.002 0.82
170_A 178_F 1 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1nu0A20.342990.90.949Contact Map0.664
1ffkW10.17889.90.95Contact Map0.141
1iv0A10.240889.50.951Contact Map0.471
1vhxA20.371786.40.953Contact Map0.64
4aybP10.12381.70.956Contact Map0.211
1vq8Z10.21275.20.958Contact Map0.653
2k4xA10.136169.10.96Contact Map0.501
1qypA10.120469.10.96Contact Map0.815
3j20Y10.130962.60.962Contact Map0.331
1vd4A10.146658.40.963Contact Map0.628
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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