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TTCA - tRNA 2-thiocytidine biosynthesis protein TtcA
UniProt: P76055 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13357
Length: 311 (282)
Sequences: 474
Seq/Len: 1.68

TTCA
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
54_T 196_I 3.533 1.00
156_Q 225_A 3.229 1.00
230_D 234_R 2.901 1.00
32_D 190_Y 2.659 1.00
138_T 181_K 2.577 1.00
249_V 254_L 2.412 1.00
87_H 91_E 2.392 1.00
135_R 139_E 2.231 0.99
106_N 109_G 2.112 0.99
261_D 264_G 1.979 0.98
103_V 136_T 1.915 0.98
91_E 95_K 1.873 0.97
38_E 69_N 1.844 0.97
136_T 140_L 1.81 0.97
275_G 278_A 1.799 0.96
217_P 222_Q 1.742 0.95
46_L 93_L 1.728 0.95
158_L 246_M 1.705 0.95
155_L 242_M 1.688 0.94
24_R 28_E 1.687 0.94
154_I 189_A 1.687 0.94
275_G 280_D 1.63 0.93
242_M 245_A 1.63 0.93
41_R 71_S 1.592 0.92
115_I 123_S 1.566 0.91
276_D 280_D 1.566 0.91
71_S 99_E 1.564 0.91
57_E 60_R 1.554 0.90
43_M 75_V 1.545 0.90
146_A 185_I 1.493 0.88
27_G 67_P 1.48 0.87
25_N 28_E 1.48 0.87
276_D 279_F 1.474 0.87
26_V 58_I 1.406 0.83
179_D 182_H 1.385 0.82
83_G 211_N 1.382 0.82
277_L 281_R 1.377 0.82
266_T 269_S 1.373 0.81
275_G 279_F 1.372 0.81
91_E 94_E 1.361 0.81
103_V 140_L 1.354 0.80
22_L 191_C 1.329 0.78
277_L 286_L 1.31 0.77
166_G 241_T 1.306 0.77
220_Q 223_V 1.279 0.75
267_H 274_G 1.259 0.73
268_G 272_V 1.256 0.73
267_H 281_R 1.251 0.72
22_L 58_I 1.242 0.72
277_L 280_D 1.235 0.71
154_I 170_G 1.233 0.71
101_K 136_T 1.227 0.70
63_Q 71_S 1.224 0.70
60_R 63_Q 1.222 0.70
192_R 232_D 1.201 0.68
285_P 288_P 1.201 0.68
9_K 284_I 1.197 0.67
63_Q 69_N 1.183 0.66
57_E 199_F 1.18 0.66
61_N 65_S 1.178 0.66
92_Y 96_L 1.171 0.65
223_V 226_D 1.169 0.65
29_A 190_Y 1.169 0.65
271_V 277_L 1.168 0.65
273_N 277_L 1.167 0.65
272_V 281_R 1.165 0.64
272_V 284_I 1.156 0.64
286_L 289_A 1.148 0.63
270_E 273_N 1.14 0.62
278_A 281_R 1.14 0.62
277_L 282_E 1.139 0.62
266_T 270_E 1.133 0.61
267_H 270_E 1.13 0.61
41_R 101_K 1.129 0.61
281_R 285_P 1.129 0.61
274_G 277_L 1.127 0.61
68_I 72_L 1.125 0.60
273_N 283_E 1.125 0.60
105_E 132_I 1.124 0.60
40_D 144_K 1.12 0.60
282_E 286_L 1.12 0.60
9_K 267_H 1.118 0.60
271_V 274_G 1.112 0.59
172_P 252_S 1.102 0.58
75_V 133_L 1.099 0.58
29_A 32_D 1.095 0.57
36_I 40_D 1.094 0.57
159_F 227_M 1.092 0.57
277_L 285_P 1.09 0.57
269_S 273_N 1.086 0.56
246_M 254_L 1.085 0.56
34_N 37_E 1.085 0.56
269_S 272_V 1.082 0.56
281_R 288_P 1.081 0.56
164_Y 220_Q 1.079 0.56
282_E 285_P 1.074 0.55
274_G 285_P 1.069 0.55
272_V 282_E 1.067 0.54
10_K 16_N 1.067 0.54
285_P 289_A 1.067 0.54
155_L 239_I 1.062 0.54
271_V 287_Q 1.061 0.54
86_E 104_E 1.061 0.54
176_M 183_I 1.06 0.54
132_I 135_R 1.06 0.54
44_V 148_G 1.059 0.53
281_R 286_L 1.058 0.53
281_R 284_I 1.056 0.53
267_H 273_N 1.056 0.53
268_G 271_V 1.056 0.53
136_T 142_A 1.049 0.52
103_V 142_A 1.045 0.52
131_G 134_Y 1.043 0.52
267_H 271_V 1.043 0.52
267_H 272_V 1.041 0.52
277_L 288_P 1.041 0.52
209_P 216_Q 1.034 0.51
8_T 272_V 1.031 0.51
281_R 289_A 1.031 0.51
151_R 192_R 1.029 0.50
111_V 120_T 1.029 0.50
127_R 134_Y 1.029 0.50
277_L 283_E 1.029 0.50
231_W 243_F 1.025 0.50
8_T 269_S 1.023 0.50
36_I 70_F 1.023 0.50
9_K 269_S 1.023 0.50
272_V 277_L 1.022 0.50
9_K 282_E 1.022 0.50
136_T 253_H 1.021 0.49
14_N 194_K 1.018 0.49
50_K 193_E 1.016 0.49
14_N 233_K 1.012 0.48
27_G 66_A 1.01 0.48
160_L 169_K 1.009 0.48
224_I 230_D 1.007 0.48
283_E 286_L 1.001 0.47
273_N 282_E 1 0.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3a2kA20.89391000.593Contact Map0.539
3vrhA10.92931000.61Contact Map0.671
1wy5A20.88751000.615Contact Map0.634
1ni5A10.87461000.634Contact Map0.574
1zunA10.91641000.721Contact Map0.436
2derA20.87141000.728Contact Map0.419
2hmaA10.8361000.74Contact Map0.415
1surA10.65271000.743Contact Map0.424
3k32A60.6271000.747Contact Map0.521
2o8vA10.72031000.747Contact Map0.376

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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