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OPENSEQ.org
LDCA - Murein tetrapeptide carboxypeptidase
UniProt: P76008 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13898
Length: 304 (292)
Sequences: 1089
Seq/Len: 3.73
LDCA
Paralog alert: 0.16 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
169_E 284_I 4.678 1.00
5_H 60_L 3.595 1.00
10_S 79_A 3.561 1.00
3_L 32_Q 3.54 1.00
50_E 81_R 3.381 1.00
8_A 73_V 3.167 1.00
4_F 31_H 2.996 1.00
49_T 52_E 2.733 1.00
3_L 34_N 2.705 1.00
41_R 52_E 2.672 1.00
169_E 282_H 2.516 1.00
189_M 221_I 2.424 1.00
172_L 277_L 2.388 1.00
6_L 73_V 2.374 1.00
199_L 230_L 2.346 1.00
58_N 90_A 2.321 1.00
193_E 224_R 2.229 1.00
227_A 285_L 2.176 1.00
69_I 101_L 2.165 1.00
34_N 63_L 2.132 1.00
225_Q 228_I 2.095 1.00
194_N 226_K 2.087 1.00
31_H 151_R 2.05 1.00
34_N 67_N 2.046 1.00
54_L 58_N 2 1.00
54_L 85_D 1.958 1.00
171_T 195_G 1.957 1.00
38_V 56_D 1.903 1.00
31_H 147_W 1.895 1.00
9_P 108_F 1.78 0.99
3_L 67_N 1.747 0.99
172_L 283_A 1.74 0.99
229_I 266_L 1.73 0.99
51_T 55_E 1.67 0.99
38_V 41_R 1.659 0.99
167_R 286_N 1.658 0.99
144_H 148_L 1.654 0.99
7_I 60_L 1.629 0.99
198_V 277_L 1.624 0.99
27_T 32_Q 1.608 0.98
55_E 59_S 1.585 0.98
112_Q 279_L 1.582 0.98
5_H 67_N 1.544 0.98
196_I 283_A 1.533 0.98
8_A 39_I 1.527 0.98
83_L 110_A 1.5 0.97
228_I 260_I 1.495 0.97
63_L 66_P 1.474 0.97
88_W 114_G 1.464 0.97
124_F 276_T 1.461 0.97
125_S 176_N 1.453 0.96
230_L 233_F 1.449 0.96
3_L 66_P 1.423 0.96
214_L 254_L 1.4 0.95
125_S 274_T 1.382 0.95
54_L 82_L 1.377 0.95
112_Q 116_L 1.376 0.95
197_L 225_Q 1.371 0.95
139_N 273_R 1.358 0.94
204_E 212_M 1.351 0.94
232_S 271_E 1.341 0.94
167_R 284_I 1.339 0.94
24_Q 27_T 1.336 0.94
29_A 147_W 1.335 0.94
284_I 295_T 1.335 0.94
90_A 98_D 1.322 0.93
29_A 151_R 1.321 0.93
112_Q 125_S 1.32 0.93
74_R 78_G 1.317 0.93
174_G 198_V 1.316 0.93
50_E 78_G 1.31 0.93
206_P 250_V 1.299 0.92
63_L 100_L 1.283 0.92
197_L 222_L 1.272 0.91
103_C 276_T 1.269 0.91
204_E 211_R 1.265 0.91
141_F 275_V 1.265 0.91
189_M 192_I 1.256 0.90
35_N 39_I 1.256 0.90
22_G 129_L 1.252 0.90
225_Q 260_I 1.243 0.90
50_E 210_E 1.241 0.90
183_L 186_T 1.24 0.90
54_L 86_I 1.239 0.90
228_I 255_R 1.237 0.90
23_I 33_V 1.232 0.89
181_I 184_I 1.223 0.89
176_N 233_F 1.216 0.89
27_T 33_V 1.215 0.88
192_I 221_I 1.214 0.88
72_A 108_F 1.2 0.88
5_H 34_N 1.191 0.87
36_V 56_D 1.184 0.87
115_L 119_G 1.184 0.87
78_G 202_I 1.18 0.86
61_A 121_V 1.18 0.86
147_W 151_R 1.177 0.86
217_Y 257_R 1.162 0.85
268_F 277_L 1.162 0.85
122_I 281_A 1.157 0.85
6_L 129_L 1.148 0.84
34_N 66_P 1.145 0.84
101_L 124_F 1.142 0.84
178_A 201_D 1.132 0.83
173_W 190_P 1.121 0.82
68_T 98_D 1.118 0.82
58_N 88_W 1.114 0.82
80_S 179_M 1.113 0.82
181_I 215_Q 1.104 0.81
190_P 221_I 1.102 0.81
77_Y 207_F 1.1 0.81
32_Q 66_P 1.093 0.80
105_H 132_N 1.09 0.80
23_I 35_N 1.087 0.80
72_A 102_I 1.081 0.79
222_L 260_I 1.075 0.79
62_R 90_A 1.072 0.78
61_A 98_D 1.07 0.78
232_S 267_D 1.069 0.78
78_G 207_F 1.065 0.78
246_N 249_S 1.06 0.77
146_F 150_L 1.059 0.77
78_G 81_R 1.059 0.77
228_I 262_L 1.058 0.77
91_L 119_G 1.057 0.77
112_Q 123_T 1.056 0.77
103_C 126_G 1.052 0.76
38_V 52_E 1.046 0.76
180_L 199_L 1.044 0.76
4_F 33_V 1.043 0.76
23_I 27_T 1.042 0.75
204_E 207_F 1.038 0.75
204_E 208_R 1.024 0.74
81_R 210_E 1.018 0.73
7_I 86_I 1.017 0.73
37_E 59_S 1.011 0.72
149_A 276_T 1.001 0.71
171_T 282_H 1 0.71
61_A 91_L 1 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4injA20.94741000.075Contact Map0.762
4e5sA40.95391000.077Contact Map0.793
3tlaA20.96711000.08Contact Map0.761
4jvoA20.96381000.082Contact Map0.761
1zl0A20.93421000.099Contact Map0.731
4eysA10.94741000.136Contact Map0.694
3g23A20.88161000.136Contact Map0.715
4jenA30.453950.70.959Contact Map0.741
3l6uA20.503348.30.96Contact Map0.588
3gbvA20.532946.90.96Contact Map0.363
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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