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OPENSEQ.org
JAYE - Putative protein JayE from lambdoid prophage e14 region
UniProt: P75981 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14254
Length: 263 (260)
Sequences: 529
Seq/Len: 2.03
JAYE
Paralog alert: 0.23 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
183_H 253_E 3.488 1.00
134_G 137_T 3.41 1.00
237_S 246_N 3.075 1.00
48_C 55_G 2.94 1.00
48_C 54_V 2.732 1.00
202_I 229_I 2.715 1.00
154_E 158_T 2.681 1.00
89_E 92_T 2.611 1.00
32_T 47_A 2.504 1.00
181_V 253_E 2.41 1.00
99_E 118_K 2.392 1.00
250_A 253_E 2.26 1.00
31_T 44_V 2.05 0.99
186_D 258_G 2.047 0.99
108_G 169_P 1.913 0.99
31_T 35_A 1.905 0.98
152_P 179_R 1.776 0.97
114_V 118_K 1.766 0.97
117_A 160_A 1.757 0.97
8_G 11_D 1.746 0.97
16_T 19_S 1.71 0.96
203_T 207_R 1.696 0.96
62_A 77_V 1.674 0.96
132_L 139_G 1.668 0.96
29_Y 57_A 1.662 0.96
19_S 31_T 1.625 0.95
226_S 238_H 1.607 0.94
158_T 162_Q 1.574 0.94
133_M 139_G 1.548 0.93
189_I 229_I 1.543 0.93
184_T 258_G 1.533 0.92
57_A 62_A 1.519 0.92
117_A 140_V 1.516 0.92
91_E 94_R 1.513 0.92
88_E 96_R 1.501 0.91
30_T 49_S 1.495 0.91
223_S 226_S 1.49 0.91
220_L 255_A 1.485 0.91
199_R 203_T 1.455 0.90
157_E 161_R 1.415 0.88
140_V 164_I 1.403 0.87
20_V 67_T 1.386 0.86
144_S 156_T 1.384 0.86
119_E 163_H 1.383 0.86
140_V 160_A 1.381 0.86
101_Y 104_T 1.369 0.85
184_T 256_V 1.364 0.85
114_V 128_T 1.359 0.85
63_L 77_V 1.357 0.85
142_I 160_A 1.354 0.85
94_R 97_V 1.35 0.84
23_R 57_A 1.348 0.84
224_R 228_A 1.345 0.84
139_G 178_F 1.34 0.84
4_M 7_E 1.323 0.83
249_I 255_A 1.307 0.82
58_D 61_T 1.301 0.81
23_R 254_L 1.291 0.80
120_V 160_A 1.267 0.79
53_A 86_D 1.228 0.76
80_T 83_G 1.225 0.75
191_V 202_I 1.222 0.75
16_T 245_D 1.211 0.74
113_Y 138_V 1.201 0.73
94_R 160_A 1.194 0.73
15_V 196_P 1.193 0.73
108_G 113_Y 1.192 0.73
141_M 252_N 1.184 0.72
18_G 90_L 1.174 0.71
93_W 97_V 1.167 0.70
186_D 256_V 1.166 0.70
108_G 112_D 1.164 0.70
113_Y 137_T 1.156 0.69
235_E 238_H 1.15 0.69
5_R 43_R 1.146 0.68
113_Y 116_W 1.142 0.68
220_L 246_N 1.136 0.67
133_M 176_Y 1.127 0.66
202_I 235_E 1.124 0.66
113_Y 169_P 1.12 0.66
137_T 176_Y 1.116 0.65
161_R 175_L 1.105 0.64
20_V 28_Q 1.103 0.64
46_I 72_L 1.094 0.63
230_S 235_E 1.089 0.62
57_A 77_V 1.088 0.62
136_G 177_V 1.074 0.61
189_I 202_I 1.073 0.61
116_W 173_S 1.071 0.61
224_R 227_E 1.066 0.60
13_L 72_L 1.058 0.59
157_E 179_R 1.057 0.59
43_R 59_D 1.055 0.59
120_V 140_V 1.054 0.59
25_D 57_A 1.054 0.59
46_I 81_L 1.049 0.58
62_A 81_L 1.048 0.58
58_D 225_I 1.047 0.58
165_G 168_A 1.043 0.58
112_D 116_W 1.042 0.57
132_L 176_Y 1.038 0.57
31_T 75_S 1.037 0.57
127_W 142_I 1.036 0.57
205_E 232_A 1.033 0.56
29_Y 63_L 1.031 0.56
107_G 112_D 1.028 0.56
97_V 101_Y 1.026 0.56
94_R 175_L 1.022 0.55
4_M 46_I 1.018 0.55
114_V 140_V 1.018 0.55
230_S 238_H 1.016 0.55
14_K 34_D 1.015 0.54
49_S 129_Y 1.003 0.53
17_A 240_L 1.001 0.53
11_D 229_I 1.001 0.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3h2tA20.581793.70.911Contact Map0.475
1yybA10.10279.70.96Contact Map0.648
4a4jA10.26246.50.963Contact Map0.331
1v54E20.36886.40.963Contact Map0.595
3zl2A10.20154.90.965Contact Map0.36
3wajA10.35744.60.966Contact Map0.137
1wloA10.51334.40.966Contact Map0.172
3gxsA10.39544.30.966Contact Map0.453
3mcbB10.220540.967Contact Map0.6
3dxsX10.281440.967Contact Map0.342
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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