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OPENSEQ.org
PGAC - Poly-beta-1,6-N-acetyl-D-glucosamine synthase
UniProt: P75905 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13863
Length: 441 (394)
Sequences: 704
Seq/Len: 1.79
PGAC
Paralog alert: 0.31 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
80_I 110_V 3.61 1.00
87_E 117_K 3.01 1.00
77_I 173_A 2.941 1.00
122_L 134_V 2.513 1.00
241_A 268_W 2.461 1.00
160_V 236_A 2.445 1.00
160_V 173_A 2.313 1.00
240_S 244_E 2.276 1.00
241_A 263_L 2.217 0.99
111_N 136_H 2.105 0.99
399_I 403_V 2.05 0.99
253_I 302_E 1.984 0.99
81_I 97_A 1.957 0.98
239_R 243_A 1.898 0.98
263_L 268_W 1.762 0.96
96_A 170_R 1.746 0.96
122_L 132_L 1.733 0.96
117_K 120_A 1.717 0.96
176_I 189_V 1.717 0.96
349_G 356_L 1.707 0.95
158_Y 180_M 1.654 0.94
358_H 361_A 1.633 0.94
158_Y 177_V 1.602 0.93
76_S 156_S 1.555 0.91
203_G 284_E 1.534 0.91
79_I 244_E 1.533 0.91
166_A 278_C 1.511 0.90
78_S 108_I 1.506 0.90
110_V 150_G 1.489 0.89
350_V 358_H 1.483 0.89
249_S 306_K 1.465 0.88
349_G 360_A 1.462 0.88
85_N 116_D 1.45 0.87
230_V 234_I 1.448 0.87
52_F 56_R 1.435 0.86
201_L 400_W 1.407 0.85
349_G 361_A 1.406 0.85
101_R 174_A 1.406 0.85
350_V 360_A 1.401 0.85
100_Q 174_A 1.398 0.84
374_L 422_L 1.392 0.84
282_M 304_F 1.392 0.84
179_P 273_E 1.376 0.83
366_G 400_W 1.36 0.82
254_T 258_D 1.356 0.82
188_A 263_L 1.35 0.81
374_L 400_W 1.34 0.81
78_S 106_E 1.335 0.80
233_V 280_I 1.32 0.79
111_N 114_S 1.318 0.79
58_R 68_A 1.31 0.79
233_V 252_M 1.31 0.79
229_T 257_I 1.293 0.77
43_I 47_V 1.291 0.77
374_L 385_N 1.287 0.77
229_T 318_R 1.278 0.76
333_A 410_L 1.274 0.76
195_I 282_M 1.266 0.75
106_E 133_R 1.263 0.75
121_I 374_L 1.255 0.74
183_N 269_T 1.25 0.74
47_V 67_P 1.248 0.74
200_T 203_G 1.246 0.74
97_A 107_V 1.243 0.73
172_A 312_W 1.234 0.73
43_I 46_I 1.232 0.72
219_R 274_P 1.229 0.72
80_I 150_G 1.229 0.72
187_G 238_R 1.224 0.72
43_I 51_Y 1.222 0.72
103_E 107_V 1.221 0.72
147_L 161_C 1.219 0.71
190_T 280_I 1.212 0.71
47_V 56_R 1.207 0.70
431_W 436_R 1.202 0.70
120_A 124_R 1.201 0.70
47_V 58_R 1.198 0.69
77_I 157_E 1.194 0.69
144_A 257_I 1.189 0.69
356_L 361_A 1.187 0.68
100_Q 173_A 1.18 0.68
147_L 191_G 1.18 0.68
82_P 281_L 1.173 0.67
178_E 182_Y 1.171 0.67
104_N 130_P 1.166 0.66
234_I 280_I 1.166 0.66
328_L 336_C 1.164 0.66
88_K 114_S 1.163 0.66
44_M 47_V 1.16 0.66
81_I 90_V 1.159 0.66
112_D 165_D 1.153 0.65
182_Y 324_F 1.152 0.65
40_F 43_I 1.151 0.65
159_L 239_R 1.15 0.65
56_R 68_A 1.148 0.65
142_G 188_A 1.143 0.64
349_G 358_H 1.139 0.64
157_E 240_S 1.138 0.64
217_I 221_Q 1.138 0.64
43_I 56_R 1.137 0.64
44_M 68_A 1.136 0.63
39_F 69_P 1.132 0.63
91_E 124_R 1.131 0.63
176_I 236_A 1.129 0.63
197_T 282_M 1.128 0.63
326_Y 410_L 1.128 0.63
55_Y 68_A 1.128 0.63
231_S 280_I 1.128 0.63
166_A 233_V 1.127 0.63
91_E 128_Q 1.125 0.62
165_D 436_R 1.123 0.62
123_D 136_H 1.123 0.62
51_Y 68_A 1.123 0.62
91_E 123_D 1.122 0.62
83_C 90_V 1.121 0.62
105_I 173_A 1.12 0.62
107_V 343_Y 1.112 0.61
143_K 299_G 1.106 0.60
218_K 221_Q 1.104 0.60
116_D 120_A 1.103 0.60
161_C 164_G 1.1 0.60
52_F 55_Y 1.098 0.60
249_S 262_K 1.096 0.59
377_F 398_I 1.096 0.59
150_G 154_A 1.092 0.59
39_F 56_R 1.089 0.59
130_P 354_I 1.087 0.58
43_I 372_L 1.086 0.58
47_V 50_V 1.082 0.58
230_V 280_I 1.081 0.58
91_E 95_H 1.08 0.58
106_E 156_S 1.079 0.58
146_A 253_I 1.077 0.57
43_I 55_Y 1.077 0.57
220_T 262_K 1.076 0.57
43_I 59_H 1.071 0.57
337_L 374_L 1.062 0.56
78_S 239_R 1.061 0.56
392_T 396_F 1.053 0.55
197_T 209_E 1.052 0.55
135_I 149_T 1.049 0.54
216_L 379_V 1.048 0.54
199_S 400_W 1.047 0.54
43_I 50_V 1.046 0.54
51_Y 59_H 1.045 0.54
51_Y 56_R 1.045 0.54
148_K 293_R 1.044 0.54
56_R 69_P 1.037 0.53
254_T 332_W 1.036 0.53
50_V 67_P 1.034 0.53
168_L 278_C 1.031 0.52
150_G 188_A 1.031 0.52
314_K 317_F 1.03 0.52
217_I 300_G 1.029 0.52
38_P 45_W 1.027 0.52
40_F 44_M 1.026 0.52
47_V 68_A 1.026 0.52
46_I 57_E 1.023 0.52
97_A 105_I 1.023 0.52
51_Y 55_Y 1.018 0.51
94_I 107_V 1.017 0.51
119_R 136_H 1.016 0.51
98_L 129_I 1.012 0.50
36_F 43_I 1.009 0.50
75_P 156_S 1.006 0.50
101_R 171_D 1.006 0.50
193_P 229_T 1.006 0.50
46_I 69_P 1.005 0.50
254_T 406_W 1.003 0.49
121_I 354_I 1.003 0.49
50_V 56_R 1.001 0.49
259_I 262_K 1 0.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hg6A10.9321000.599Contact Map0.366
2z86A40.70291000.729Contact Map0.547
1qg8A10.52611000.736Contact Map0.605
3bcvA20.50571000.74Contact Map0.625
1xhbA10.78681000.756Contact Map0.469
2bo4A60.76421000.757Contact Map0.272
3l7iA40.76641000.757Contact Map0.392
2d7iA10.88891000.765Contact Map0.516
3ckjA10.6781000.766Contact Map0.468
4fixA20.83671000.769Contact Map0.506
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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