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OPENSEQ.org

EFEU - Putative inactive ferrous iron permease EfeU
UniProt: P75901 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13860
Length: 276 (268)
Sequences: 782
Seq/Len: 2.92

EFEU
Paralog alert: 0.17 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
5_F 160_T 3.38 1.00
70_L 74_I 3.022 1.00
98_K 102_E 2.595 1.00
26_L 38_M 2.335 1.00
16_A 165_G 2.144 1.00
47_A 51_G 2.101 1.00
53_G 132_L 2.074 1.00
245_V 249_A 2.037 1.00
200_I 250_V 1.998 1.00
84_T 254_Y 1.957 1.00
23_A 35_D 1.757 0.99
9_L 160_T 1.753 0.99
52_L 128_A 1.74 0.99
166_F 170_W 1.725 0.98
125_F 235_G 1.716 0.98
135_V 157_G 1.698 0.98
19_V 42_V 1.648 0.98
159_A 163_V 1.632 0.98
76_A 199_A 1.606 0.97
51_G 55_F 1.577 0.97
233_M 237_F 1.518 0.96
6_L 177_L 1.514 0.96
36_C 40_I 1.505 0.96
75_V 188_I 1.487 0.95
40_I 44_L 1.476 0.95
21_L 97_V 1.473 0.95
6_L 74_I 1.47 0.95
199_A 203_F 1.463 0.95
55_F 59_T 1.406 0.93
165_G 169_Y 1.405 0.93
216_A 245_V 1.4 0.93
230_G 239_Y 1.383 0.92
9_L 164_L 1.379 0.92
15_A 137_F 1.374 0.92
49_C 131_G 1.373 0.92
16_A 168_L 1.37 0.92
28_R 180_F 1.367 0.92
23_A 27_K 1.359 0.91
18_I 24_S 1.344 0.91
43_L 47_A 1.338 0.90
126_A 173_I 1.334 0.90
46_A 50_L 1.333 0.90
156_L 164_L 1.325 0.90
155_M 159_A 1.322 0.90
204_H 244_S 1.322 0.90
47_A 257_P 1.309 0.89
111_R 158_L 1.296 0.88
77_V 203_F 1.295 0.88
69_E 205_E 1.292 0.88
83_L 136_F 1.285 0.88
215_I 242_A 1.284 0.88
78_I 121_M 1.28 0.88
67_E 199_A 1.273 0.87
47_A 186_L 1.251 0.86
87_V 91_R 1.249 0.86
76_A 198_G 1.244 0.85
152_L 156_L 1.241 0.85
15_A 90_M 1.24 0.85
49_C 53_G 1.23 0.85
99_V 103_Q 1.218 0.84
107_S 110_Q 1.214 0.84
211_H 228_L 1.209 0.83
83_L 188_I 1.2 0.83
68_Q 203_F 1.197 0.82
70_L 206_A 1.195 0.82
151_P 209_W 1.178 0.81
31_R 174_R 1.176 0.81
187_F 229_F 1.169 0.80
44_L 120_V 1.168 0.80
22_I 244_S 1.167 0.80
47_A 152_L 1.167 0.80
243_P 248_V 1.166 0.80
45_A 140_A 1.164 0.80
68_Q 72_E 1.163 0.80
32_G 35_D 1.159 0.79
237_F 240_Q 1.155 0.79
11_E 14_E 1.149 0.79
78_I 166_F 1.14 0.78
21_L 193_A 1.135 0.77
75_V 97_V 1.13 0.77
8_M 157_G 1.125 0.77
140_A 243_P 1.122 0.76
74_I 162_V 1.12 0.76
215_I 243_P 1.108 0.75
17_L 223_L 1.104 0.75
250_V 258_A 1.102 0.74
169_Y 191_V 1.097 0.74
89_W 153_G 1.096 0.74
69_E 78_I 1.096 0.74
109_L 124_F 1.093 0.74
258_A 262_F 1.093 0.74
9_L 12_G 1.09 0.73
112_G 125_F 1.089 0.73
200_I 244_S 1.089 0.73
45_A 192_A 1.088 0.73
166_F 171_G 1.087 0.73
222_V 229_F 1.083 0.73
169_Y 194_G 1.083 0.73
151_P 155_M 1.081 0.72
7_I 134_S 1.079 0.72
20_S 228_L 1.078 0.72
185_S 189_L 1.077 0.72
122_M 165_G 1.073 0.72
19_V 160_T 1.071 0.71
101_L 126_A 1.061 0.70
99_V 249_A 1.058 0.70
163_V 167_L 1.055 0.70
125_F 179_A 1.053 0.70
89_W 174_R 1.052 0.70
15_A 126_A 1.05 0.69
39_W 42_V 1.05 0.69
86_M 254_Y 1.049 0.69
46_A 51_G 1.049 0.69
90_M 189_L 1.047 0.69
35_D 45_A 1.045 0.69
249_A 253_I 1.039 0.68
8_M 58_E 1.038 0.68
23_A 38_M 1.035 0.68
208_L 258_A 1.034 0.68
128_A 194_G 1.034 0.68
199_A 247_E 1.032 0.67
52_L 185_S 1.019 0.66
72_E 205_E 1.016 0.66
21_L 161_A 1.016 0.66
257_P 260_V 1.012 0.65
77_V 261_A 1.011 0.65
158_L 190_F 1.01 0.65
73_G 202_A 1.01 0.65
87_V 161_A 1.007 0.65
169_Y 193_A 1.005 0.64
219_M 239_Y 1.003 0.64
121_M 179_A 1.001 0.64
28_R 102_E 1.001 0.64
38_M 124_F 1 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2wswA10.6051170.962Contact Map0.159
2kluA10.1637.30.968Contact Map0.366
4b19A10.10515.60.97Contact Map0.39
2xq2A10.36965.50.97Contact Map0.309
2jwaA20.15225.40.97Contact Map0.577
2ks1B10.155850.97Contact Map0.008
2rddB10.12324.20.971Contact Map0.082
3rlbA20.34423.90.972Contact Map0.366
3o7qA10.9423.50.972Contact Map0.181
2lx0A10.115930.973Contact Map0.764

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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