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OPENSEQ.org
LTAE - Low specificity L-threonine aldolase
UniProt: P75823 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13690
Length: 333 (331)
Sequences: 1511
Seq/Len: 4.56
LTAE
Paralog alert: 0.13 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
153_W 157_R 3.977 1.00
18_E 22_A 3.852 1.00
262_Q 324_A 3.681 1.00
258_W 321_A 3.633 1.00
117_A 158_E 3.389 1.00
195_L 238_G 3.101 1.00
255_N 317_R 3.078 1.00
156_T 163_L 3.011 1.00
42_Y 239_I 2.925 1.00
42_Y 243_K 2.602 1.00
133_L 156_T 2.591 1.00
258_W 317_R 2.396 1.00
13_S 245_N 2.369 1.00
153_W 163_L 2.284 1.00
80_Q 104_D 2.283 1.00
203_V 234_L 2.261 1.00
260_A 273_Q 2.2 1.00
165_V 188_C 2.186 1.00
297_R 329_A 2.108 1.00
79_G 105_A 2.086 1.00
190_S 213_Y 2.055 1.00
131_K 162_A 2.002 1.00
316_S 319_Q 1.946 1.00
15_A 244_N 1.941 1.00
240_Y 244_N 1.93 1.00
116_V 152_A 1.914 1.00
133_L 152_A 1.91 1.00
113_L 155_F 1.895 1.00
110_T 148_Y 1.866 1.00
55_L 64_V 1.864 1.00
66_L 132_L 1.813 1.00
38_A 239_I 1.787 1.00
112_P 115_K 1.739 1.00
256_A 278_L 1.72 0.99
299_V 326_H 1.719 0.99
69_H 190_S 1.718 0.99
77_I 116_V 1.717 0.99
40_Q 218_I 1.708 0.99
74_E 129_R 1.68 0.99
55_L 61_A 1.67 0.99
117_A 159_R 1.664 0.99
295_K 300_L 1.626 0.99
50_E 211_R 1.604 0.99
163_L 188_C 1.572 0.99
135_L 149_L 1.569 0.99
71_E 74_E 1.568 0.99
85_Y 102_P 1.56 0.99
150_K 187_Y 1.538 0.99
277_M 310_V 1.532 0.98
248_R 251_E 1.531 0.98
84_N 134_S 1.522 0.98
254_D 317_R 1.522 0.98
14_R 18_E 1.518 0.98
38_A 243_K 1.507 0.98
47_S 170_I 1.503 0.98
56_P 60_Q 1.494 0.98
200_G 204_G 1.479 0.98
147_E 151_E 1.46 0.98
36_V 231_S 1.46 0.98
322_E 326_H 1.454 0.98
180_E 183_E 1.443 0.97
74_E 131_K 1.434 0.97
38_A 42_Y 1.425 0.97
149_L 184_I 1.422 0.97
261_E 265_E 1.416 0.97
18_E 21_M 1.411 0.97
17_L 21_M 1.408 0.97
66_L 98_I 1.397 0.97
259_M 262_Q 1.385 0.97
257_A 261_E 1.38 0.96
15_A 240_Y 1.38 0.96
322_E 325_A 1.378 0.96
199_L 204_G 1.372 0.96
41_D 45_E 1.372 0.96
155_F 159_R 1.354 0.96
65_A 207_L 1.352 0.96
150_K 154_E 1.344 0.96
240_Y 245_N 1.343 0.96
48_G 182_K 1.341 0.96
15_A 249_L 1.336 0.96
104_D 115_K 1.328 0.95
309_L 323_V 1.318 0.95
154_E 158_E 1.302 0.95
61_A 192_T 1.297 0.95
162_A 210_N 1.294 0.94
116_V 155_F 1.294 0.94
301_I 309_L 1.293 0.94
11_R 314_D 1.284 0.94
195_L 206_L 1.28 0.94
75_E 101_Q 1.273 0.94
317_R 321_A 1.269 0.94
292_E 295_K 1.253 0.93
269_D 281_R 1.242 0.93
37_N 40_Q 1.237 0.92
259_M 320_L 1.225 0.92
24_P 38_A 1.217 0.92
135_L 152_A 1.215 0.92
43_A 193_I 1.214 0.92
92_A 100_P 1.213 0.92
147_E 150_K 1.212 0.91
69_H 132_L 1.206 0.91
149_L 187_Y 1.204 0.91
292_E 296_A 1.201 0.91
63_L 96_G 1.199 0.91
56_P 228_M 1.198 0.91
146_R 150_K 1.196 0.91
190_S 210_N 1.192 0.91
76_Y 100_P 1.189 0.90
42_Y 46_L 1.188 0.90
35_T 236_A 1.187 0.90
170_I 181_L 1.181 0.90
207_L 217_A 1.18 0.90
164_H 190_S 1.178 0.90
165_V 184_I 1.173 0.90
53_I 217_A 1.171 0.90
184_I 187_Y 1.171 0.90
146_R 179_C 1.161 0.89
55_L 206_L 1.16 0.89
185_T 191_F 1.153 0.89
204_G 253_H 1.152 0.88
171_F 193_I 1.151 0.88
68_S 213_Y 1.139 0.88
280_V 309_L 1.138 0.88
291_G 301_I 1.138 0.88
114_D 117_A 1.137 0.88
249_L 253_H 1.134 0.87
293_Y 330_F 1.123 0.87
120_I 155_F 1.12 0.87
69_H 213_Y 1.115 0.86
11_R 24_P 1.112 0.86
71_E 216_R 1.111 0.86
49_K 208_V 1.111 0.86
43_A 206_L 1.11 0.86
259_M 323_V 1.103 0.85
144_L 148_Y 1.098 0.85
138_T 275_T 1.095 0.85
70_C 98_I 1.092 0.85
265_E 328_R 1.084 0.84
103_I 111_L 1.081 0.84
126_H 222_K 1.079 0.84
13_S 200_G 1.069 0.83
248_R 313_L 1.068 0.83
117_A 155_F 1.066 0.83
200_G 245_N 1.063 0.82
30_Y 302_N 1.062 0.82
38_A 41_D 1.061 0.82
220_W 223_M 1.06 0.82
150_K 186_Q 1.059 0.82
143_V 176_A 1.054 0.82
6_S 9_V 1.045 0.81
120_I 159_R 1.044 0.81
200_G 251_E 1.034 0.80
239_I 243_K 1.025 0.79
28_D 232_G 1.022 0.79
288_A 292_E 1.018 0.78
250_Q 254_D 1.018 0.78
204_G 249_L 1.014 0.78
39_L 235_A 1.013 0.78
177_Y 184_I 1.013 0.78
245_N 313_L 1.011 0.78
247_A 250_Q 1.01 0.78
12_P 202_P 1.01 0.78
16_M 240_Y 1.009 0.78
93_A 99_Q 1.007 0.77
175_V 248_R 1.004 0.77
54_F 238_G 1.003 0.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1jg8A40.9971000.533Contact Map0.866
4lnjA211000.579Contact Map0.745
1v72A10.9851000.591Contact Map0.631
3lwsA60.9731000.637Contact Map0.63
3pj0A40.9731000.641Contact Map0.659
2oqxA10.9761000.647Contact Map0.575
1svvA20.9761000.674Contact Map0.763
2ez2A20.9731000.701Contact Map0.671
1fc4A20.9611000.716Contact Map0.685
3tqxA20.9671000.721Contact Map0.682
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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