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OPENSEQ.org
YAIX - Putative uncharacterized acetyltransferase YaiX
UniProt: P75697 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14236
Length: 230 (219)
Sequences: 273
Seq/Len: 1.25
YAIX
Paralog alert: 0.25 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
34_L 43_K 2.45 0.99
80_I 84_V 2.017 0.97
90_C 108_V 1.885 0.95
107_G 124_E 1.84 0.95
198_I 204_L 1.831 0.94
32_N 182_Q 1.764 0.93
173_C 176_L 1.748 0.92
116_I 119_A 1.654 0.89
117_K 146_A 1.634 0.89
164_T 167_G 1.598 0.87
88_A 106_N 1.595 0.87
162_V 176_L 1.588 0.87
62_T 68_I 1.588 0.87
112_F 129_P 1.574 0.86
111_G 129_P 1.525 0.84
59_I 62_T 1.524 0.84
161_S 167_G 1.519 0.83
189_Q 204_L 1.47 0.80
129_P 146_A 1.467 0.80
167_G 170_A 1.436 0.78
186_L 192_I 1.424 0.77
55_D 61_E 1.42 0.77
68_I 80_I 1.41 0.76
27_Q 123_A 1.407 0.76
159_P 169_I 1.402 0.76
164_T 168_I 1.388 0.75
116_I 130_Q 1.385 0.75
184_S 198_I 1.384 0.75
108_V 124_E 1.376 0.74
144_L 153_H 1.362 0.73
1_M 85_V 1.358 0.73
37_E 46_V 1.345 0.72
173_C 183_R 1.321 0.70
161_S 165_P 1.317 0.69
14_A 109_K 1.31 0.69
69_G 72_T 1.296 0.68
87_G 90_C 1.292 0.67
116_I 133_I 1.288 0.67
57_V 88_A 1.285 0.67
10_A 13_S 1.282 0.66
84_V 198_I 1.28 0.66
11_N 18_P 1.265 0.65
29_L 103_I 1.258 0.64
132_F 140_N 1.237 0.62
69_G 114_T 1.235 0.62
74_I 84_V 1.225 0.61
111_G 146_A 1.225 0.61
9_D 146_A 1.221 0.61
117_K 134_A 1.219 0.61
68_I 71_N 1.207 0.59
92_I 200_P 1.2 0.59
55_D 62_T 1.2 0.59
108_V 197_I 1.197 0.58
131_C 148_V 1.195 0.58
178_C 181_G 1.194 0.58
13_S 178_C 1.193 0.58
36_Q 43_K 1.192 0.58
13_S 220_S 1.192 0.58
74_I 104_I 1.187 0.57
56_Q 62_T 1.186 0.57
34_L 103_I 1.183 0.57
50_N 176_L 1.18 0.57
165_P 168_I 1.178 0.57
165_P 169_I 1.172 0.56
10_A 15_T 1.167 0.56
109_K 186_L 1.164 0.55
9_D 19_A 1.16 0.55
84_V 98_I 1.156 0.54
99_R 134_A 1.149 0.54
7_L 127_I 1.149 0.54
133_I 138_V 1.139 0.53
71_N 88_A 1.138 0.53
31_P 137_V 1.136 0.53
16_N 19_A 1.13 0.52
80_I 86_I 1.124 0.51
133_I 197_I 1.119 0.51
56_Q 59_I 1.119 0.51
146_A 194_P 1.117 0.51
121_I 144_L 1.106 0.50
56_Q 88_A 1.1 0.49
117_K 143_Y 1.099 0.49
35_S 38_L 1.099 0.49
99_R 152_N 1.098 0.49
120_V 137_V 1.098 0.49
3_L 8_L 1.093 0.48
138_V 144_L 1.089 0.48
213_N 217_G 1.072 0.46
64_G 74_I 1.072 0.46
126_T 142_A 1.072 0.46
81_Q 84_V 1.069 0.46
75_C 79_V 1.069 0.46
155_L 173_C 1.067 0.46
3_L 86_I 1.061 0.45
176_L 183_R 1.061 0.45
124_E 127_I 1.06 0.45
9_D 13_S 1.059 0.45
88_A 108_V 1.058 0.45
189_Q 216_T 1.058 0.45
43_K 103_I 1.05 0.44
133_I 148_V 1.044 0.43
141_Q 183_R 1.042 0.43
15_T 117_K 1.042 0.43
15_T 111_G 1.041 0.43
92_I 135_D 1.038 0.43
4_L 8_L 1.035 0.43
103_I 162_V 1.024 0.42
29_L 34_L 1.014 0.41
87_G 217_G 1.01 0.40
186_L 190_V 1.01 0.40
99_R 117_K 1.009 0.40
175_K 178_C 1.009 0.40
3_L 16_N 1.007 0.40
147_Q 189_Q 1.006 0.40
191_I 194_P 1.005 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ggoA10.93041000.521Contact Map0.294
1hm9A20.89571000.587Contact Map0.303
4g3qA10.89571000.595Contact Map0.29
3st8A10.89571000.595Contact Map0.294
4fceA10.965299.90.611Contact Map0.26
2v0hA10.965299.90.615Contact Map0.288
1yp2A40.743599.90.619Contact Map0.342
3r8yA60.765299.90.657Contact Map0.366
3brkX10.717499.90.657Contact Map0.351
2iu8A30.969699.90.664Contact Map0.406
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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