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OPENSEQ.org
YAFS - Uncharacterized protein YafS
UniProt: P75672 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13331
Length: 240 (222)
Sequences: 677
Seq/Len: 3.05
YAFS
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
84_L 116_V 3.14 1.00
112_E 115_R 2.702 1.00
86_F 91_V 2.6 1.00
163_L 204_A 2.33 1.00
113_A 123_L 2.097 1.00
45_L 93_V 2.002 1.00
161_D 165_L 1.975 1.00
16_W 132_S 1.967 1.00
107_H 165_L 1.887 0.99
158_R 161_D 1.845 0.99
122_W 203_V 1.766 0.99
48_I 84_L 1.715 0.99
114_D 168_F 1.714 0.99
106_P 110_L 1.677 0.98
96_L 113_A 1.672 0.98
122_W 205_R 1.601 0.97
148_P 151_S 1.596 0.97
117_L 121_G 1.558 0.97
180_P 198_C 1.557 0.97
134_M 198_C 1.543 0.97
32_Q 35_P 1.52 0.96
46_L 94_C 1.519 0.96
101_P 151_S 1.512 0.96
44_H 64_H 1.489 0.96
161_D 166_L 1.467 0.95
221_N 224_R 1.461 0.95
215_P 218_Q 1.46 0.95
46_L 91_V 1.457 0.95
117_L 206_K 1.455 0.95
47_K 51_L 1.441 0.94
84_L 112_E 1.44 0.94
130_P 200_Q 1.434 0.94
107_H 111_R 1.423 0.94
84_L 115_R 1.422 0.94
130_P 158_R 1.414 0.94
120_D 207_R 1.41 0.94
94_C 113_A 1.4 0.93
68_V 79_A 1.38 0.93
214_N 218_Q 1.379 0.93
111_R 165_L 1.354 0.92
162_W 166_L 1.344 0.91
48_I 113_A 1.323 0.90
16_W 135_G 1.313 0.90
169_E 207_R 1.308 0.90
101_P 127_G 1.298 0.89
107_H 110_L 1.293 0.89
33_L 126_S 1.269 0.88
48_I 81_P 1.259 0.87
222_K 225_I 1.258 0.87
186_G 189_L 1.256 0.87
120_D 205_R 1.256 0.87
49_G 97_A 1.254 0.87
81_P 109_L 1.244 0.86
127_G 200_Q 1.234 0.86
106_P 162_W 1.232 0.86
46_L 116_V 1.23 0.86
112_E 116_V 1.23 0.86
107_H 162_W 1.216 0.85
108_R 166_L 1.214 0.84
89_K 119_D 1.213 0.84
58_E 164_S 1.209 0.84
114_D 206_K 1.206 0.84
21_W 198_C 1.192 0.83
171_L 203_V 1.172 0.82
111_R 166_L 1.154 0.80
107_H 166_L 1.147 0.80
220_K 223_P 1.146 0.79
42_G 96_L 1.146 0.79
91_V 94_C 1.145 0.79
33_L 124_V 1.145 0.79
111_R 162_W 1.144 0.79
33_L 201_L 1.141 0.79
181_W 197_G 1.139 0.79
87_A 90_S 1.132 0.78
121_G 206_K 1.127 0.78
162_W 165_L 1.122 0.77
41_Y 62_V 1.121 0.77
126_S 201_L 1.118 0.77
46_L 86_F 1.105 0.76
117_L 148_P 1.098 0.75
96_L 123_L 1.096 0.75
134_M 137_R 1.095 0.75
134_M 180_P 1.093 0.75
88_D 115_R 1.086 0.74
98_H 126_S 1.084 0.74
106_P 161_D 1.073 0.73
220_K 224_R 1.072 0.73
176_F 179_L 1.059 0.72
107_H 161_D 1.049 0.70
128_F 135_G 1.048 0.70
220_K 225_I 1.044 0.70
168_F 220_K 1.043 0.70
156_L 173_A 1.041 0.70
91_V 117_L 1.035 0.69
83_H 118_I 1.035 0.69
106_P 165_L 1.029 0.68
30_E 124_V 1.022 0.68
68_V 77_V 1.021 0.67
139_L 159_Q 1.019 0.67
47_K 97_A 1.019 0.67
47_K 53_A 1.014 0.67
191_A 195_A 1.012 0.66
104_T 147_S 1.003 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gs9A20.81251000.536Contact Map0.576
1vlmA20.812599.90.617Contact Map0.652
4htfA10.887599.90.635Contact Map0.554
2p7iA20.854299.90.641Contact Map0.583
2avnA20.8599.90.645Contact Map0.63
3cc8A10.829299.90.659Contact Map0.583
3l8dA10.887599.80.667Contact Map0.632
3bkwA20.845899.80.668Contact Map0.688
2yqzA20.966799.80.676Contact Map0.622
3busA20.862599.80.676Contact Map0.621
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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