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OPENSEQ.org
WCAJ - Putative colanic biosynthesis UDP-glucose lipid carrier transferase
UniProt: P71241 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13575
Length: 464 (454)
Sequences: 1632
Seq/Len: 3.59
WCAJ
Paralog alert: 0.24 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
329_S 356_L 5.418 1.00
296_I 361_L 4.833 1.00
275_R 279_I 4.716 1.00
299_A 352_V 4.386 1.00
303_S 351_K 4.151 1.00
286_L 368_I 3.933 1.00
370_V 408_I 3.809 1.00
296_I 356_L 3.262 1.00
367_F 377_I 3.014 1.00
277_E 281_L 2.909 1.00
377_I 450_V 2.748 1.00
281_L 377_I 2.71 1.00
313_T 321_P 2.592 1.00
311_R 323_K 2.514 1.00
429_K 432_E 2.508 1.00
355_F 359_T 2.5 1.00
300_V 303_S 2.386 1.00
411_W 415_N 2.352 1.00
313_T 323_K 2.239 1.00
295_C 299_A 2.167 1.00
297_A 308_V 2.075 1.00
352_V 356_L 2.058 1.00
384_A 387_H 2.047 1.00
289_I 293_L 2.02 1.00
383_H 387_H 2.002 1.00
356_L 359_T 2.001 1.00
301_K 308_V 2 1.00
391_Y 427_M 1.941 1.00
175_G 191_G 1.916 1.00
383_H 427_M 1.894 1.00
285_I 289_I 1.89 1.00
301_K 306_G 1.886 1.00
356_L 361_L 1.879 1.00
367_F 408_I 1.876 1.00
412_A 419_G 1.875 1.00
89_T 116_Y 1.852 1.00
383_H 391_Y 1.851 0.99
207_N 235_L 1.839 0.99
160_M 176_V 1.823 0.99
283_T 371_L 1.781 0.99
344_Q 464_Y 1.758 0.99
422_D 426_K 1.754 0.99
452_L 456_K 1.727 0.99
80_E 131_R 1.726 0.99
285_I 377_I 1.717 0.99
290_S 294_C 1.705 0.99
387_H 391_Y 1.687 0.99
290_S 293_L 1.678 0.99
153_L 156_G 1.667 0.99
436_E 440_E 1.656 0.99
315_Y 321_P 1.637 0.98
156_G 176_V 1.613 0.98
293_L 309_I 1.602 0.98
149_V 176_V 1.601 0.98
360_S 418_R 1.597 0.98
32_G 36_V 1.587 0.98
341_Q 387_H 1.584 0.98
141_G 170_G 1.58 0.98
144_K 172_E 1.566 0.98
279_I 282_A 1.563 0.98
100_A 110_K 1.555 0.98
427_M 430_R 1.554 0.98
384_A 388_N 1.55 0.98
282_A 286_L 1.549 0.98
360_S 441_W 1.533 0.97
383_H 412_A 1.531 0.97
309_I 325_W 1.529 0.97
252_E 255_G 1.528 0.97
138_R 143_N 1.52 0.97
40_S 110_K 1.518 0.97
383_H 388_N 1.515 0.97
282_A 371_L 1.496 0.97
349_V 354_N 1.487 0.97
100_A 103_N 1.486 0.97
277_E 443_V 1.484 0.97
368_I 374_G 1.483 0.97
195_Q 198_E 1.468 0.96
278_D 376_S 1.456 0.96
443_V 447_I 1.446 0.96
351_K 354_N 1.446 0.96
448_K 452_L 1.442 0.96
275_R 282_A 1.441 0.96
198_E 202_A 1.437 0.96
341_Q 384_A 1.436 0.96
333_M 337_K 1.431 0.96
149_V 156_G 1.431 0.96
311_R 325_W 1.426 0.96
283_T 287_L 1.418 0.95
147_V 171_F 1.406 0.95
418_R 441_W 1.402 0.95
367_F 450_V 1.386 0.95
368_I 372_T 1.372 0.94
310_F 384_A 1.362 0.94
384_A 427_M 1.357 0.94
345_N 354_N 1.351 0.94
364_L 367_F 1.341 0.93
295_C 298_L 1.338 0.93
341_Q 383_H 1.338 0.93
36_V 40_S 1.338 0.93
146_M 172_E 1.337 0.93
325_W 372_T 1.336 0.93
175_G 190_A 1.332 0.93
285_I 367_F 1.321 0.93
119_T 122_G 1.32 0.93
192_N 195_Q 1.32 0.93
411_W 433_F 1.318 0.92
315_Y 388_N 1.312 0.92
292_V 296_I 1.296 0.92
387_H 427_M 1.293 0.92
391_Y 431_V 1.288 0.91
149_V 211_A 1.286 0.91
313_T 386_A 1.283 0.91
296_I 327_F 1.282 0.91
383_H 430_R 1.279 0.91
331_K 347_P 1.266 0.90
383_H 431_V 1.261 0.90
303_S 350_T 1.261 0.90
307_P 332_V 1.261 0.90
418_R 430_R 1.26 0.90
316_G 406_P 1.256 0.90
383_H 386_A 1.253 0.90
149_V 160_M 1.251 0.90
412_A 427_M 1.245 0.89
384_A 391_Y 1.245 0.89
411_W 436_E 1.245 0.89
24_S 126_C 1.239 0.89
419_G 430_R 1.225 0.88
293_L 327_F 1.22 0.88
177_Y 199_D 1.217 0.88
341_Q 420_E 1.217 0.88
303_S 356_L 1.213 0.88
457_G 462_A 1.212 0.88
378_V 409_T 1.204 0.87
301_K 305_P 1.202 0.87
298_L 302_L 1.199 0.87
427_M 431_V 1.197 0.87
325_W 369_N 1.195 0.87
398_Y 412_A 1.19 0.86
293_L 364_L 1.183 0.86
103_N 109_L 1.183 0.86
411_W 445_F 1.176 0.85
286_L 290_S 1.174 0.85
416_G 430_R 1.174 0.85
134_A 170_G 1.167 0.85
412_A 462_A 1.16 0.84
342_A 387_H 1.159 0.84
293_L 296_I 1.155 0.84
310_F 335_N 1.153 0.84
386_A 391_Y 1.152 0.84
291_P 294_C 1.14 0.83
402_H 419_G 1.14 0.83
412_A 433_F 1.137 0.83
315_Y 322_I 1.128 0.82
73_R 138_R 1.126 0.82
134_A 141_G 1.12 0.81
279_I 283_T 1.12 0.81
134_A 138_R 1.119 0.81
421_T 430_R 1.118 0.81
416_G 441_W 1.115 0.81
148_A 177_Y 1.115 0.81
342_A 412_A 1.113 0.81
387_H 402_H 1.111 0.81
383_H 398_Y 1.109 0.80
138_R 170_G 1.106 0.80
383_H 419_G 1.104 0.80
383_H 402_H 1.102 0.80
419_G 427_M 1.101 0.80
412_A 415_N 1.101 0.80
100_A 109_L 1.099 0.80
92_V 116_Y 1.099 0.80
387_H 412_A 1.095 0.79
387_H 433_F 1.09 0.79
312_Q 383_H 1.087 0.79
378_V 450_V 1.086 0.79
411_W 440_E 1.085 0.78
342_A 398_Y 1.084 0.78
281_L 450_V 1.084 0.78
210_I 261_L 1.081 0.78
301_K 304_S 1.081 0.78
289_I 292_V 1.081 0.78
274_K 278_D 1.076 0.78
417_W 433_F 1.076 0.78
148_A 199_D 1.075 0.78
383_H 396_E 1.073 0.77
388_N 420_E 1.07 0.77
312_Q 384_A 1.069 0.77
312_Q 427_M 1.067 0.77
146_M 206_H 1.066 0.77
398_Y 402_H 1.062 0.76
309_I 368_I 1.06 0.76
156_G 211_A 1.057 0.76
156_G 178_H 1.054 0.76
391_Y 406_P 1.053 0.75
44_F 309_I 1.053 0.75
152_D 179_D 1.046 0.75
216_D 219_R 1.042 0.74
148_A 190_A 1.04 0.74
385_V 388_N 1.033 0.73
388_N 402_H 1.032 0.73
199_D 203_G 1.027 0.73
402_H 412_A 1.027 0.73
329_S 447_I 1.025 0.73
352_V 355_F 1.023 0.72
342_A 427_M 1.022 0.72
398_Y 427_M 1.02 0.72
339_V 387_H 1.018 0.72
451_F 455_F 1.017 0.72
279_I 367_F 1.011 0.71
277_E 447_I 1.01 0.71
28_I 32_G 1.01 0.71
292_V 295_C 1.01 0.71
295_C 303_S 1.004 0.70
134_A 143_N 1.002 0.70
200_A 232_C 1.001 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nklA20.27899.30.9Contact Map0.729
3keoA20.428998.10.935Contact Map0.536
2py6A10.6897980.937Contact Map0.267
2dt5A20.428997.90.938Contact Map0.548
2vt3A20.439797.60.942Contact Map0.581
4m98A10.439796.20.952Contact Map0.504
4ea9A10.336296.10.953Contact Map0.575
4e2xA10.495793.80.959Contact Map0.391
3ff4A10.2591.20.962Contact Map0.588
1iukA10.282380.20.968Contact Map0.544
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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