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OPENSEQ.org
HDA - DnaA regulatory inactivator Hda
UniProt: P69931 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14201
Length: 233 (227)
Sequences: 1688
Seq/Len: 7.44
HDA
Paralog alert: 0.41 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
175_Q 187_E 3.295 1.00
63_A 133_L 2.902 1.00
66_E 69_Q 2.861 1.00
67_L 98_L 2.527 1.00
94_E 120_L 2.449 1.00
31_L 35_Q 2.419 1.00
28_S 31_L 2.278 1.00
189_V 227_V 2.116 1.00
171_L 191_R 2.076 1.00
209_D 216_I 2.064 1.00
28_S 35_Q 2.004 1.00
24_P 31_L 1.985 1.00
105_E 137_D 1.928 1.00
224_I 228_K 1.925 1.00
174_L 204_L 1.915 1.00
30_L 35_Q 1.867 1.00
27_N 30_L 1.856 1.00
19_F 62_A 1.854 1.00
174_L 208_L 1.835 1.00
87_P 90_L 1.828 1.00
167_D 171_L 1.804 1.00
32_A 36_N 1.782 1.00
60_L 135_T 1.769 1.00
75_G 96_L 1.733 1.00
215_S 226_F 1.709 1.00
29_S 32_A 1.667 1.00
121_Y 132_L 1.659 1.00
125_L 156_W 1.654 1.00
141_R 155_D 1.643 1.00
66_E 70_R 1.626 1.00
22_F 59_L 1.623 1.00
173_A 201_M 1.618 1.00
200_E 203_T 1.612 1.00
27_N 146_G 1.571 1.00
115_M 119_D 1.569 1.00
33_A 46_I 1.565 1.00
176_L 180_L 1.564 1.00
178_A 190_G 1.563 1.00
166_S 169_D 1.54 1.00
122_N 126_E 1.527 1.00
119_D 122_N 1.51 0.99
177_R 205_F 1.487 0.99
27_N 145_L 1.481 0.99
189_V 224_I 1.442 0.99
193_L 211_L 1.431 0.99
186_P 189_V 1.405 0.99
33_A 158_Q 1.392 0.99
211_L 227_V 1.387 0.99
60_L 102_D 1.37 0.99
171_L 190_G 1.343 0.98
214_A 226_F 1.337 0.98
28_S 32_A 1.331 0.98
222_L 226_F 1.327 0.98
220_R 229_E 1.31 0.98
94_E 116_A 1.31 0.98
116_A 120_L 1.306 0.98
124_I 129_K 1.296 0.98
29_S 35_Q 1.293 0.98
197_L 207_T 1.289 0.98
49_W 152_S 1.273 0.98
225_P 228_K 1.266 0.97
80_D 106_C 1.264 0.97
185_L 190_G 1.262 0.97
100_C 135_T 1.259 0.97
30_L 37_V 1.257 0.97
150_L 154_L 1.249 0.97
152_S 200_E 1.247 0.97
181_R 209_D 1.235 0.97
211_L 222_L 1.231 0.97
80_D 120_L 1.223 0.97
118_F 122_N 1.199 0.96
218_A 229_E 1.195 0.96
140_P 159_I 1.192 0.96
67_L 72_D 1.189 0.96
192_F 224_I 1.186 0.96
226_F 230_I 1.184 0.96
34_L 63_A 1.182 0.96
45_Y 121_Y 1.161 0.95
114_E 146_G 1.16 0.95
60_L 100_C 1.151 0.95
50_A 150_L 1.147 0.95
82_R 85_F 1.138 0.95
90_L 116_A 1.138 0.95
102_D 135_T 1.129 0.94
191_R 195_K 1.129 0.94
77_V 93_M 1.127 0.94
32_A 35_Q 1.124 0.94
215_S 222_L 1.123 0.94
82_R 89_V 1.113 0.94
108_A 143_L 1.108 0.93
202_R 206_M 1.108 0.93
51_R 54_A 1.104 0.93
47_Y 159_I 1.104 0.93
36_N 90_L 1.104 0.93
214_A 218_A 1.096 0.93
118_F 149_D 1.088 0.93
148_P 151_A 1.086 0.93
80_D 94_E 1.074 0.92
168_E 172_Q 1.072 0.92
175_Q 190_G 1.069 0.92
67_L 70_R 1.064 0.92
196_R 224_I 1.042 0.90
203_T 231_L 1.041 0.90
68_S 71_G 1.039 0.90
227_V 230_I 1.016 0.89
229_E 232_K 1.013 0.89
77_V 101_I 1.01 0.88
178_A 208_L 1.007 0.88
30_L 36_N 1.007 0.88
29_S 36_N 1.006 0.88
27_N 35_Q 1.005 0.88
97_S 129_K 1.004 0.88
214_A 230_I 1.002 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bosA20.99571000.416Contact Map0.714
2z4sA10.99571000.424Contact Map0.72
1l8qA10.94851000.49Contact Map0.592
3nbxX10.95281000.595Contact Map0.379
2kjqA10.639599.90.649Contact Map0.454
2vhjA30.89799.90.659Contact Map0.177
1in4A10.948599.90.659Contact Map0.715
3uk6A120.957199.90.668Contact Map0.545
1sxjD10.939999.90.669Contact Map0.519
2c9oA30.961499.90.671Contact Map0.716
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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