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OPENSEQ.org
DCEB - Glutamate decarboxylase beta
UniProt: P69910 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11490
Length: 466 (423)
Sequences: 2808
Seq/Len: 6.64
DCEB
Paralog alert: 0.47 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: DCEA DCEB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
219_F 222_P 5.591 1.00
195_I 233_D 5.002 1.00
352_Y 435_E 3.849 1.00
244_A 248_G 3.838 1.00
205_V 231_Q 3.613 1.00
229_K 266_R 3.604 1.00
193_R 196_E 3.299 1.00
364_E 381_K 3.276 1.00
356_E 359_K 3.233 1.00
183_R 188_F 2.906 1.00
35_H 337_E 2.876 1.00
402_R 443_A 2.699 1.00
74_K 78_L 2.697 1.00
207_P 223_L 2.614 1.00
356_E 438_L 2.414 1.00
181_P 193_R 2.39 1.00
195_I 234_T 2.341 1.00
356_E 435_E 2.308 1.00
232_A 266_R 2.253 1.00
231_Q 240_M 2.235 1.00
156_N 199_D 2.224 1.00
352_Y 431_M 2.177 1.00
109_H 261_D 2.143 1.00
123_T 129_A 2.094 1.00
180_I 197_A 2.088 1.00
198_C 230_F 2.061 1.00
207_P 240_M 2.045 1.00
229_K 233_D 2.044 1.00
103_M 332_L 2.018 1.00
244_A 270_I 2.006 1.00
364_E 383_K 2 1.00
193_R 197_A 1.995 1.00
205_V 223_L 1.978 1.00
355_D 359_K 1.949 1.00
191_P 230_F 1.944 1.00
137_M 204_G 1.934 1.00
354_A 365_F 1.921 1.00
156_N 202_T 1.908 1.00
228_D 240_M 1.883 1.00
156_N 176_E 1.88 1.00
167_H 179_E 1.801 1.00
190_D 193_R 1.779 1.00
194_M 223_L 1.76 1.00
352_Y 356_E 1.744 1.00
157_L 170_A 1.74 1.00
230_F 233_D 1.738 1.00
183_R 190_D 1.737 1.00
133_G 287_V 1.733 1.00
207_P 220_P 1.73 1.00
222_P 229_K 1.715 1.00
191_P 222_P 1.704 1.00
360_L 442_K 1.683 1.00
156_N 178_R 1.675 1.00
234_T 238_I 1.659 1.00
34_L 336_R 1.653 1.00
228_D 266_R 1.653 1.00
192_K 196_E 1.628 1.00
70_E 74_K 1.616 1.00
261_D 264_L 1.594 1.00
44_Q 48_D 1.584 1.00
398_R 447_Y 1.58 1.00
195_I 199_D 1.576 1.00
348_Q 431_M 1.575 1.00
198_C 238_I 1.571 1.00
221_Q 229_K 1.562 0.99
135_M 173_W 1.557 0.99
230_F 234_T 1.521 0.99
228_D 232_A 1.515 0.99
180_I 189_M 1.497 0.99
221_Q 266_R 1.496 0.99
129_A 271_S 1.481 0.99
399_L 406_V 1.481 0.99
195_I 230_F 1.477 0.99
131_M 172_Y 1.476 0.99
134_G 204_G 1.459 0.99
130_C 165_C 1.455 0.99
397_E 401_L 1.444 0.99
229_K 232_A 1.436 0.99
291_D 294_A 1.43 0.99
357_I 363_Y 1.409 0.99
440_D 443_A 1.397 0.99
349_V 434_A 1.387 0.98
220_P 242_I 1.364 0.98
38_R 41_V 1.36 0.98
398_R 401_L 1.36 0.98
221_Q 259_V 1.359 0.98
340_T 344_N 1.359 0.98
204_G 241_H 1.357 0.98
41_V 44_Q 1.35 0.98
435_E 439_E 1.349 0.98
394_D 398_R 1.343 0.98
354_A 357_I 1.323 0.98
60_L 63_F 1.319 0.98
247_G 270_I 1.312 0.98
220_P 240_M 1.301 0.97
354_A 358_A 1.298 0.97
124_I 128_E 1.296 0.97
107_L 336_R 1.283 0.97
144_R 148_A 1.274 0.97
422_R 425_C 1.269 0.97
423_I 437_L 1.263 0.97
350_A 378_V 1.247 0.96
395_L 444_S 1.247 0.96
353_L 425_C 1.232 0.96
198_C 202_T 1.231 0.96
417_D 422_R 1.228 0.96
158_V 197_A 1.224 0.96
366_I 381_K 1.223 0.96
61_A 64_C 1.219 0.96
73_H 77_D 1.206 0.95
196_E 200_E 1.204 0.95
337_E 341_K 1.203 0.95
170_A 177_L 1.194 0.95
199_D 202_T 1.187 0.95
199_D 234_T 1.181 0.95
336_R 340_T 1.171 0.94
228_D 264_L 1.169 0.94
274_G 327_Q 1.163 0.94
34_L 337_E 1.162 0.94
341_K 345_A 1.157 0.94
159_C 177_L 1.156 0.94
289_W 295_L 1.154 0.94
266_R 290_R 1.15 0.94
64_C 67_W 1.149 0.94
45_I 332_L 1.14 0.93
108_W 272_A 1.137 0.93
103_M 106_D 1.136 0.93
444_S 447_Y 1.136 0.93
44_Q 47_N 1.134 0.93
161_P 181_P 1.134 0.93
242_I 267_V 1.133 0.93
95_A 99_R 1.132 0.93
130_C 241_H 1.126 0.93
416_T 422_R 1.122 0.93
102_N 106_D 1.122 0.93
180_I 193_R 1.121 0.93
272_A 286_W 1.121 0.93
103_M 328_Y 1.117 0.92
106_D 109_H 1.116 0.92
353_L 378_V 1.115 0.92
61_A 66_T 1.114 0.92
221_Q 264_L 1.104 0.92
356_E 442_K 1.102 0.92
350_A 354_A 1.101 0.92
205_V 238_I 1.101 0.92
345_A 349_V 1.098 0.92
436_L 440_D 1.097 0.92
158_V 202_T 1.095 0.91
246_S 376_P 1.091 0.91
209_F 247_G 1.089 0.91
409_F 412_G 1.087 0.91
97_D 319_R 1.071 0.90
43_F 47_N 1.071 0.90
37_M 42_A 1.068 0.90
223_L 240_M 1.064 0.90
183_R 186_Q 1.064 0.90
179_E 223_L 1.059 0.90
77_D 81_N 1.055 0.89
106_D 335_G 1.052 0.89
322_G 325_I 1.052 0.89
59_N 63_F 1.051 0.89
120_G 288_I 1.05 0.89
189_M 223_L 1.048 0.89
415_A 418_I 1.043 0.89
109_H 263_R 1.04 0.88
360_L 363_Y 1.039 0.88
274_G 284_C 1.038 0.88
351_A 355_D 1.036 0.88
103_M 335_G 1.034 0.88
208_T 212_T 1.033 0.88
430_E 433_F 1.032 0.88
439_E 443_A 1.032 0.88
159_C 179_E 1.03 0.88
42_A 333_R 1.029 0.88
178_R 197_A 1.028 0.88
111_P 291_D 1.022 0.87
59_N 64_C 1.021 0.87
31_R 106_D 1.018 0.87
210_G 375_I 1.016 0.87
176_E 199_D 1.013 0.87
192_K 195_I 1.013 0.87
134_G 169_F 1.011 0.86
126_S 130_C 1.011 0.86
432_D 436_L 1.01 0.86
77_D 80_I 1.009 0.86
347_Y 351_A 1.008 0.86
355_D 358_A 1.008 0.86
129_A 285_G 1.007 0.86
37_M 45_I 1.005 0.86
62_T 66_T 1.005 0.86
367_C 371_P 1.002 0.86
362_P 383_K 1.002 0.86
90_Y 94_A 1 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2dgkA60.971000.492Contact Map0.674
3vp6A20.93781000.496Contact Map0.768
4e1oA60.92271000.499Contact Map0.773
2jisA20.91631000.5Contact Map0.786
1js3A20.94211000.5Contact Map0.679
2qmaA20.9121000.509Contact Map0.684
3k40A20.92271000.514Contact Map0.715
3hbxA60.96781000.514Contact Map0.718
3mc6A10.92921000.537Contact Map0.622
3f9tA20.81971000.594Contact Map0.75
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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