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OPENSEQ.org

PTQB - N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB component
UniProt: P69795 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10140
Length: 106 (99)
Sequences: 712
Seq/Len: 7.19

PTQB
Paralog alert: 0.53 [within 20: 0.08] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
64_L 68_Q 3.542 1.00
30_Y 94_K 3.056 1.00
80_D 95_A 2.361 1.00
19_L 92_V 2.324 1.00
83_L 88_D 1.991 1.00
45_G 70_L 1.97 1.00
21_S 24_R 1.964 1.00
90_L 94_K 1.897 1.00
20_V 36_I 1.819 1.00
23_M 36_I 1.788 1.00
80_D 83_L 1.7 1.00
26_Q 30_Y 1.644 1.00
53_V 99_A 1.616 1.00
25_A 28_E 1.588 1.00
88_D 91_G 1.57 1.00
83_L 91_G 1.54 1.00
44_A 67_I 1.538 1.00
5_H 35_I 1.514 0.99
15_S 84_Y 1.481 0.99
14_M 17_S 1.47 0.99
21_S 25_A 1.424 0.99
63_M 66_E 1.402 0.99
77_E 99_A 1.391 0.99
68_Q 72_P 1.387 0.99
7_Y 51_A 1.377 0.99
30_Y 90_L 1.365 0.99
26_Q 89_G 1.353 0.98
7_Y 39_F 1.316 0.98
25_A 29_K 1.291 0.98
44_A 54_V 1.25 0.97
93_L 97_V 1.242 0.97
8_L 16_T 1.224 0.97
10_C 13_G 1.17 0.95
34_V 97_V 1.134 0.94
65_P 68_Q 1.123 0.94
91_G 94_K 1.112 0.93
69_R 72_P 1.077 0.92
32_V 97_V 1.072 0.91
64_L 78_V 1.067 0.91
9_F 44_A 1.066 0.91
64_L 76_V 1.051 0.90
26_Q 29_K 1.045 0.90
37_E 51_A 1.027 0.89
83_L 92_V 1.024 0.89
18_L 21_S 1.024 0.89
83_L 95_A 1.006 0.88
27_A 93_L 1.003 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nbmA10.924599.90.275Contact Map0.604
1e2bA1199.90.275Contact Map0.715
4mgeA20.971799.90.312Contact Map0.816
2l2qA1199.90.35Contact Map0.545
2kyrA10.93499.90.367Contact Map0.507
2m1zA10.915199.80.395Contact Map0.407
2r4qA10.924599.80.42Contact Map0.577
1tvmA10.877499.50.536Contact Map0.34
3czcA10.877499.30.604Contact Map0.438
1vkrA10.924599.10.634Contact Map0.46

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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