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OPENSEQ.org
PTGA - Glucose-specific phosphotransferase enzyme IIA component
UniProt: P69783 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10165
Length: 169 (150)
Sequences: 1727
Seq/Len: 11.51
PTGA
Paralog alert: 0.76 [within 20: 0.05] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
45_K 49_D 3.832 1.00
92_F 121_I 3.003 1.00
65_D 115_K 2.842 1.00
69_G 81_E 2.796 1.00
64_V 82_S 2.773 1.00
107_I 119_T 2.703 1.00
109_E 112_Q 2.685 1.00
105_K 122_E 2.658 1.00
28_S 57_G 2.61 1.00
37_V 52_A 2.469 1.00
83_D 113_R 2.458 1.00
107_I 122_E 2.374 1.00
59_K 119_T 2.333 1.00
127_L 131_K 2.288 1.00
98_E 133_K 2.282 1.00
103_G 127_L 2.212 1.00
59_K 122_E 2.124 1.00
102_E 131_K 2.063 1.00
67_T 113_R 2.051 1.00
115_K 118_D 2.02 1.00
38_P 134_S 1.996 1.00
75_N 106_R 1.995 1.00
54_K 134_S 1.932 1.00
58_N 125_L 1.88 1.00
60_M 90_V 1.864 1.00
65_D 116_V 1.845 1.00
27_L 60_M 1.838 1.00
35_E 45_K 1.814 1.00
30_E 54_K 1.794 1.00
24_I 116_V 1.773 1.00
92_F 123_F 1.672 1.00
38_P 136_L 1.659 1.00
102_E 127_L 1.581 1.00
32_V 136_L 1.509 1.00
61_V 119_T 1.454 1.00
40_V 44_E 1.448 1.00
27_L 137_T 1.446 1.00
135_T 138_P 1.441 1.00
126_P 130_E 1.421 1.00
126_P 129_E 1.412 1.00
112_Q 118_D 1.379 0.99
66_G 80_I 1.368 0.99
64_V 80_I 1.331 0.99
125_L 135_T 1.324 0.99
125_L 129_E 1.289 0.99
79_S 142_S 1.286 0.99
68_I 108_A 1.276 0.99
67_T 81_E 1.248 0.99
123_F 128_L 1.236 0.98
54_K 135_T 1.233 0.98
31_I 51_I 1.229 0.98
25_A 53_I 1.224 0.98
106_R 121_I 1.216 0.98
78_F 121_I 1.205 0.98
28_S 158_T 1.203 0.98
65_D 83_D 1.2 0.98
71_I 110_E 1.196 0.98
28_S 56_T 1.191 0.98
62_A 80_I 1.183 0.98
87_E 143_N 1.182 0.98
143_N 147_I 1.166 0.97
86_V 167_I 1.166 0.97
99_L 127_L 1.164 0.97
158_T 161_E 1.161 0.97
86_V 147_I 1.158 0.97
71_I 106_R 1.144 0.97
119_T 122_E 1.127 0.97
41_V 46_I 1.119 0.96
33_N 36_D 1.093 0.96
61_V 159_V 1.074 0.95
99_L 103_G 1.066 0.95
62_A 65_D 1.065 0.95
99_L 102_E 1.064 0.95
28_S 159_V 1.064 0.95
68_I 80_I 1.061 0.95
75_N 105_K 1.052 0.95
60_M 123_F 1.052 0.95
52_A 136_L 1.043 0.94
49_D 144_M 1.035 0.94
78_F 120_V 1.029 0.94
127_L 130_E 1.016 0.93
94_I 138_P 1.012 0.93
157_V 160_G 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ourB411000.022Contact Map0.822
1f3zA10.95271000.077Contact Map0.805
2gprA10.90531000.102Contact Map0.759
1ax3A10.95271000.134Contact Map0.651
1dczA10.449797.90.846Contact Map0.287
2d5dA20.43297.90.848Contact Map0.296
1z6hA10.402496.50.878Contact Map0.244
2dn8A10.491196.20.881Contact Map0.343
1bdoA10.408396.10.882Contact Map0.324
2ejmA10.4852960.883Contact Map0.362
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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