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YTFE - Iron-sulfur cluster repair protein YtfE
UniProt: P69506 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12505
Length: 220 (219)
Sequences: 289
Seq/Len: 1.32
YTFE
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
47_D 50_V 2.75 1.00
137_L 156_M 2.305 0.99
24_K 54_E 2.242 0.99
77_D 142_K 2.153 0.99
101_V 190_M 2.137 0.98
206_S 210_N 1.982 0.97
122_L 163_A 1.935 0.97
25_Y 51_I 1.865 0.96
152_P 156_M 1.749 0.93
50_V 54_E 1.731 0.93
97_Q 186_T 1.724 0.93
79_I 212_L 1.722 0.92
187_W 191_Y 1.722 0.92
163_A 166_L 1.719 0.92
8_L 27_M 1.686 0.91
109_P 182_E 1.659 0.91
83_Y 86_R 1.587 0.88
29_Y 207_L 1.587 0.88
106_A 206_S 1.557 0.86
115_L 174_T 1.546 0.86
137_L 152_P 1.521 0.85
196_E 200_D 1.501 0.84
115_L 170_I 1.478 0.82
94_L 193_G 1.466 0.82
112_P 187_W 1.463 0.81
179_P 188_K 1.455 0.81
195_N 199_D 1.448 0.80
70_A 74_E 1.421 0.79
67_W 70_A 1.396 0.77
167_L 170_I 1.387 0.76
115_L 119_L 1.383 0.76
122_L 166_L 1.376 0.76
8_L 11_L 1.368 0.75
115_L 186_T 1.354 0.74
90_Q 193_G 1.351 0.74
122_L 197_L 1.343 0.73
74_E 81_V 1.307 0.70
71_P 74_E 1.297 0.69
39_R 49_E 1.288 0.68
21_L 51_I 1.281 0.68
100_K 103_R 1.281 0.68
105_H 184_C 1.266 0.67
31_C 164_G 1.26 0.66
28_D 164_G 1.248 0.65
25_Y 54_E 1.246 0.65
28_D 33_G 1.236 0.64
76_I 135_Q 1.23 0.63
80_I 142_K 1.219 0.62
9_G 210_N 1.218 0.62
21_L 58_L 1.217 0.62
119_L 190_M 1.214 0.62
9_G 13_L 1.205 0.61
49_E 53_A 1.204 0.61
165_E 168_E 1.202 0.61
18_A 101_V 1.198 0.60
194_I 198_I 1.197 0.60
157_E 163_A 1.192 0.60
131_M 135_Q 1.184 0.59
177_V 198_I 1.172 0.58
28_D 186_T 1.172 0.58
72_L 215_R 1.167 0.57
46_L 91_L 1.167 0.57
5_D 44_K 1.166 0.57
66_D 69_S 1.163 0.57
11_L 37_L 1.163 0.57
104_V 186_T 1.156 0.56
92_P 210_N 1.152 0.56
30_C 164_G 1.138 0.54
83_Y 187_W 1.137 0.54
11_L 52_E 1.13 0.54
16_P 193_G 1.128 0.53
169_V 172_H 1.124 0.53
46_L 197_L 1.113 0.52
152_P 201_L 1.112 0.52
90_Q 196_E 1.106 0.51
28_D 210_N 1.105 0.51
153_I 174_T 1.104 0.51
164_G 186_T 1.096 0.50
7_P 162_E 1.089 0.49
132_K 152_P 1.083 0.49
122_L 170_I 1.078 0.48
12_A 189_A 1.074 0.48
78_H 215_R 1.071 0.48
184_C 209_N 1.07 0.48
31_C 184_C 1.064 0.47
8_L 20_A 1.055 0.46
31_C 105_H 1.052 0.46
149_A 215_R 1.051 0.46
28_D 31_C 1.045 0.45
94_L 187_W 1.039 0.44
136_I 156_M 1.038 0.44
40_A 183_A 1.032 0.44
166_L 173_T 1.03 0.44
36_T 186_T 1.028 0.43
132_K 137_L 1.027 0.43
4_R 48_V 1.027 0.43
19_S 189_A 1.026 0.43
93_E 205_I 1.026 0.43
198_I 202_M 1.023 0.43
73_A 81_V 1.019 0.43
29_Y 106_A 1.017 0.42
136_I 211_V 1.016 0.42
141_I 210_N 1.015 0.42
78_H 189_A 1.013 0.42
97_Q 179_P 1.009 0.42
189_A 193_G 1.007 0.41
153_I 205_I 1.006 0.41
31_C 100_K 1.006 0.41
112_P 119_L 1.005 0.41
179_P 183_A 1.005 0.41
29_Y 206_S 1.004 0.41
30_C 184_C 1.004 0.41
183_A 191_Y 1.003 0.41
53_A 64_E 1 0.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3caxA10.677399.90.722Contact Map0.27
2p0nA20.799.80.767Contact Map0.223
2k5eA10.304599.50.817Contact Map0.347
2k53A10.327399.50.817Contact Map0.629
2fi0A10.399.10.848Contact Map0.525
4brcA20.340923.70.963Contact Map0.426
2oa4A10.386419.30.964Contact Map0.346
4hf0A20.3318180.965Contact Map0.551
3kp1A40.390915.30.966Contact Map0.021
2kebA10.39559.10.969Contact Map0.133
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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