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OPENSEQ.org

YOEB - Toxin YoeB
UniProt: P69348 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14356
Length: 84 (84)
Sequences: 562
Seq/Len: 6.69

YOEB
Paralog alert: 0.10 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
61_T 64_H 3.54 1.00
13_Y 28_N 2.59 1.00
33_D 42_K 2.414 1.00
47_P 56_W 2.272 1.00
23_I 61_T 2.241 1.00
55_F 69_A 2.165 1.00
33_D 37_T 2.067 1.00
55_F 78_A 1.95 1.00
37_T 40_E 1.816 1.00
17_Q 28_N 1.79 1.00
23_I 64_H 1.789 1.00
39_F 56_W 1.75 1.00
15_Y 81_R 1.652 1.00
3_L 35_R 1.632 1.00
31_I 77_I 1.567 0.99
66_L 80_C 1.564 0.99
39_F 70_V 1.536 0.99
24_V 28_N 1.419 0.99
39_F 47_P 1.386 0.98
30_L 66_L 1.374 0.98
10_W 13_Y 1.351 0.98
15_Y 19_T 1.34 0.98
13_Y 17_Q 1.337 0.98
34_T 75_L 1.333 0.98
14_L 17_Q 1.303 0.97
41_G 58_R 1.289 0.97
69_A 76_L 1.282 0.97
58_R 68_Y 1.258 0.97
71_T 76_L 1.239 0.96
2_K 73_D 1.222 0.96
6_S 78_A 1.216 0.96
17_Q 24_V 1.196 0.95
7_E 35_R 1.183 0.95
60_I 66_L 1.173 0.95
41_G 68_Y 1.15 0.94
27_I 60_I 1.149 0.94
10_W 36_R 1.129 0.93
12_D 15_Y 1.122 0.93
4_I 74_S 1.119 0.93
44_K 62_E 1.096 0.92
16_W 23_I 1.033 0.88
21_K 26_K 1.029 0.88
5_W 80_C 1.014 0.87
50_H 76_L 1.005 0.86
16_W 27_I 1.002 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3oeiC8199.80.465Contact Map0.769
2a6sA4199.70.505Contact Map0.872
1z8mA10.988199.50.572Contact Map0.355
2otrA10.988199.40.601Contact Map0.372
3bpqB20.940598.90.672Contact Map0.451
3g5oB20.916798.90.681Contact Map0.573
1wmiA20.952498.80.692Contact Map0.593
4fxiA30.916798.70.695Contact Map0.526
2kheA10.916798.40.726Contact Map0.529
3kxeA20.928696.70.804Contact Map0.648

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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