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OPENSEQ.org

IF1 - Translation initiation factor IF-1
UniProt: P69222 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10504
Length: 72 (72)
Sequences: 665
Seq/Len: 9.24

IF1
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
27_E 52_K 2.756 1.00
40_M 69_F 2.579 1.00
54_T 71_S 2.239 1.00
14_L 25_E 2.159 1.00
12_T 25_E 2.157 1.00
25_E 29_G 2.093 1.00
32_V 65_G 1.996 1.00
25_E 31_V 1.971 1.00
22_F 41_R 1.91 1.00
16_T 49_T 1.646 1.00
13_V 47_I 1.624 1.00
9_M 57_L 1.58 1.00
10_Q 52_K 1.575 1.00
17_L 23_R 1.556 1.00
8_E 54_T 1.458 1.00
36_I 44_Y 1.445 1.00
12_T 52_K 1.424 0.99
36_I 40_M 1.413 0.99
21_M 33_T 1.383 0.99
23_R 31_V 1.374 0.99
10_Q 54_T 1.373 0.99
5_D 50_G 1.354 0.99
21_M 35_H 1.33 0.99
18_P 33_T 1.315 0.99
44_Y 47_I 1.266 0.98
42_K 50_G 1.261 0.98
55_V 65_G 1.227 0.98
15_E 23_R 1.203 0.98
12_T 34_A 1.123 0.96
40_M 71_S 1.106 0.96
16_T 31_V 1.092 0.95
10_Q 27_E 1.042 0.93
10_Q 71_S 1.03 0.93
36_I 71_S 1.014 0.92
33_T 64_K 1.014 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4bpe010.972299.90.304Contact Map0.623
2oqkA10.972299.90.324Contact Map0.612
4kzyn10.986199.90.331Contact Map0.556
1jt8A10.972299.90.346Contact Map0.434
1hr0W10.986199.90.375Contact Map0.601
3i4oA2199.80.383Contact Map0.725
1ah9A10.986199.80.393Contact Map0.53
2dgyA10.930699.80.395Contact Map0.553
2k52A10.986197.30.774Contact Map0.336
2khiA10.9861970.786Contact Map0.379

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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