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OPENSEQ.org
CUTC - Copper homeostasis protein CutC
UniProt: P67826 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12956
Length: 248 (244)
Sequences: 720
Seq/Len: 2.95
CUTC
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
124_F 164_L 3.584 1.00
72_F 105_R 3.567 1.00
175_A 192_V 2.731 1.00
102_D 105_R 2.646 1.00
184_L 195_V 2.612 1.00
135_N 166_A 2.489 1.00
29_A 36_L 2.471 1.00
172_I 194_E 2.464 1.00
101_V 120_F 2.4 1.00
30_A 36_L 2.365 1.00
43_L 82_V 2.295 1.00
138_A 171_P 2.219 1.00
96_D 100_N 2.114 1.00
76_L 112_A 2.044 1.00
14_A 46_V 2.03 1.00
44_K 77_E 2.024 1.00
76_L 108_K 2.017 1.00
144_R 194_E 2.007 1.00
101_V 137_L 1.982 1.00
16_T 20_N 1.929 0.99
55_H 143_A 1.905 0.99
55_H 117_A 1.879 0.99
130_P 160_K 1.853 0.99
120_F 137_L 1.841 0.99
135_N 170_A 1.79 0.99
117_A 143_A 1.748 0.99
57_I 92_T 1.739 0.99
68_S 71_E 1.726 0.98
46_V 54_V 1.711 0.98
41_G 78_D 1.676 0.98
118_V 142_I 1.673 0.98
138_A 170_A 1.657 0.98
94_V 105_R 1.652 0.98
90_L 117_A 1.651 0.98
130_P 150_Q 1.64 0.98
9_Y 31_P 1.63 0.98
77_E 80_R 1.602 0.97
56_P 87_F 1.593 0.97
230_V 235_V 1.542 0.96
96_D 102_D 1.531 0.96
232_G 236_A 1.53 0.96
47_R 54_V 1.505 0.96
106_M 142_I 1.505 0.96
239_K 243_E 1.503 0.96
23_D 239_K 1.495 0.95
131_L 163_E 1.495 0.95
185_H 189_D 1.483 0.95
150_Q 160_K 1.482 0.95
72_F 94_V 1.474 0.95
175_A 179_V 1.459 0.95
58_I 82_V 1.45 0.94
43_L 87_F 1.441 0.94
28_C 119_T 1.441 0.94
122_R 148_S 1.428 0.94
153_D 177_A 1.411 0.93
201_A 231_D 1.398 0.93
47_R 88_P 1.33 0.90
75_I 109_I 1.309 0.89
74_A 78_D 1.304 0.89
165_I 173_I 1.292 0.88
165_I 192_V 1.27 0.87
61_R 71_E 1.268 0.87
55_H 91_V 1.255 0.86
158_L 187_F 1.252 0.86
19_Q 232_G 1.25 0.86
6_I 199_A 1.242 0.86
61_R 64_D 1.24 0.85
103_M 136_N 1.222 0.84
82_V 90_L 1.22 0.84
110_M 140_L 1.216 0.84
72_F 76_L 1.212 0.84
197_S 238_M 1.21 0.84
131_L 166_A 1.209 0.83
18_Q 52_I 1.202 0.83
58_I 75_I 1.197 0.83
15_L 50_V 1.197 0.83
211_N 225_Y 1.184 0.82
17_A 21_G 1.172 0.81
17_A 22_A 1.17 0.81
80_R 112_A 1.169 0.81
135_N 138_A 1.167 0.80
55_H 144_R 1.164 0.80
148_S 154_A 1.163 0.80
237_E 241_I 1.143 0.78
181_A 234_A 1.142 0.78
137_L 142_I 1.133 0.78
153_D 156_Q 1.109 0.75
28_C 63_G 1.103 0.75
134_L 145_V 1.092 0.74
90_L 116_L 1.084 0.73
83_R 115_P 1.078 0.72
14_A 50_V 1.077 0.72
7_C 28_C 1.075 0.72
28_C 91_V 1.074 0.72
83_R 116_L 1.074 0.72
13_C 28_C 1.067 0.71
215_S 225_Y 1.066 0.71
175_A 194_E 1.044 0.69
18_Q 51_T 1.04 0.69
40_L 85_L 1.036 0.68
122_R 176_G 1.036 0.68
40_L 44_K 1.027 0.67
154_A 157_G 1.027 0.67
82_V 92_T 1.027 0.67
55_H 89_G 1.024 0.67
124_F 130_P 1.022 0.67
8_C 25_V 1.016 0.66
41_G 74_A 1.015 0.66
18_Q 50_V 1.01 0.65
119_T 172_I 1.008 0.65
36_L 122_R 1.004 0.65
145_V 173_I 1.004 0.65
141_G 198_S 1.003 0.64
167_H 171_P 1.002 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1twdA20.9961000.253Contact Map0.792
3iwpA120.9961000.293Contact Map0.873
2bdqA20.86291000.46Contact Map0.742
3f4wA20.810599.40.833Contact Map0.567
1h1yA20.798499.40.834Contact Map0.585
4adtA20.87199.30.834Contact Map0.423
1geqA20.842799.30.838Contact Map0.401
3tsmA20.798499.30.838Contact Map0.506
4ml9A20.846899.30.839Contact Map0.453
3q58A20.774299.20.844Contact Map0.601
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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