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OPENSEQ.org
YFCE - Phosphodiesterase YfcE
UniProt: P67095 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14108
Length: 184 (169)
Sequences: 2008
Seq/Len: 11.88
YFCE
Paralog alert: 0.27 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
142_F 159_G 4.172 1.00
35_L 124_V 3.968 1.00
33_V 103_L 3.838 1.00
5_M 24_F 3.186 1.00
101_L 122_V 2.942 1.00
23_L 158_Y 2.511 1.00
6_F 124_V 2.485 1.00
35_L 103_L 2.443 1.00
5_M 29_A 2.334 1.00
31_W 68_I 2.285 1.00
10_I 34_I 2.235 1.00
95_L 98_K 2.018 1.00
99_Q 121_D 2.005 1.00
100_R 121_D 1.866 1.00
25_A 63_V 1.784 1.00
14_L 55_K 1.784 1.00
10_I 147_V 1.783 1.00
6_F 161_L 1.76 1.00
18_E 59_R 1.72 1.00
38_V 69_A 1.699 1.00
102_F 120_N 1.674 1.00
133_A 140_F 1.668 1.00
86_P 89_A 1.666 1.00
27_S 169_I 1.657 1.00
52_A 55_K 1.639 1.00
170_A 174_Q 1.554 1.00
73_N 127_H 1.54 1.00
131_P 157_S 1.537 1.00
68_I 92_Q 1.482 1.00
21_L 59_R 1.427 1.00
125_Y 141_H 1.397 0.99
6_F 142_F 1.378 0.99
144_P 159_G 1.372 0.99
146_S 150_P 1.371 0.99
8_S 35_L 1.37 0.99
125_Y 132_V 1.364 0.99
8_S 126_G 1.363 0.99
5_M 20_V 1.315 0.99
3_K 160_M 1.306 0.99
24_F 158_Y 1.303 0.99
128_T 143_N 1.296 0.99
94_V 101_L 1.286 0.99
159_G 168_V 1.28 0.99
103_L 124_V 1.268 0.99
34_I 38_V 1.254 0.99
7_A 20_V 1.247 0.99
95_L 100_R 1.243 0.98
37_D 73_N 1.221 0.98
106_G 128_T 1.207 0.98
20_V 158_Y 1.203 0.98
34_I 69_A 1.2 0.98
131_P 168_V 1.199 0.98
11_H 129_H 1.198 0.98
5_M 158_Y 1.197 0.98
54_A 57_A 1.194 0.98
79_D 82_L 1.187 0.98
3_K 162_D 1.183 0.98
24_F 29_A 1.178 0.98
29_A 160_M 1.169 0.97
74_C 151_K 1.16 0.97
89_A 92_Q 1.144 0.97
54_A 58_E 1.143 0.97
133_A 168_V 1.142 0.97
13_S 148_S 1.125 0.97
13_S 16_A 1.119 0.96
32_L 67_V 1.112 0.96
25_A 65_H 1.101 0.96
22_E 25_A 1.098 0.96
59_R 63_V 1.089 0.96
152_G 157_S 1.085 0.96
9_D 129_H 1.081 0.95
3_K 30_Q 1.079 0.95
158_Y 169_I 1.075 0.95
24_F 32_L 1.072 0.95
59_R 62_E 1.069 0.95
7_A 17_T 1.064 0.95
41_H 151_K 1.054 0.95
38_V 56_V 1.044 0.94
16_A 156_A 1.037 0.94
20_V 156_A 1.018 0.93
124_V 161_L 1.01 0.93
18_E 22_E 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1su1A40.99461000.35Contact Map0.798
1nnwA20.95651000.398Contact Map0.658
3qfmA20.95111000.427Contact Map0.882
3ck2A10.85871000.439Contact Map0.841
3rqzA30.94021000.444Contact Map0.77
1s3lA20.84781000.448Contact Map0.754
1z2wA20.885999.90.465Contact Map0.708
2a22A20.929399.90.468Contact Map0.802
2kknA10.78899.90.474Contact Map0.618
1g5bA30.820799.90.491Contact Map0.68
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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