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OPENSEQ.org
MLAE - Probable phospholipid ABC transporter permease protein MlaE
UniProt: P64606 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12800
Length: 260 (256)
Sequences: 1783
Seq/Len: 6.96
MLAE
Paralog alert: 0.24 [within 20: 0.05] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
212_T 249_L 5.678 1.00
216_I 245_A 4.32 1.00
224_A 234_A 3.361 1.00
48_L 154_S 3.31 1.00
44_L 149_W 2.827 1.00
26_M 140_L 2.537 1.00
44_L 153_I 2.328 1.00
151_G 214_T 2.279 1.00
30_A 148_F 2.272 1.00
60_V 161_I 2.267 1.00
98_E 205_K 2.086 1.00
63_G 162_F 2.019 1.00
98_E 250_D 1.982 1.00
60_V 165_V 1.905 1.00
49_Y 54_L 1.832 1.00
95_L 166_G 1.811 1.00
220_N 237_R 1.783 1.00
205_K 250_D 1.761 1.00
106_L 243_S 1.757 1.00
116_L 218_L 1.688 1.00
120_I 143_V 1.65 1.00
33_G 138_D 1.635 1.00
208_V 249_L 1.63 1.00
148_F 211_I 1.624 1.00
139_P 222_Y 1.61 1.00
220_N 241_H 1.589 1.00
50_N 54_L 1.586 1.00
171_S 182_S 1.577 1.00
208_V 253_L 1.574 1.00
170_G 185_F 1.571 1.00
113_G 217_S 1.566 1.00
51_V 116_L 1.566 1.00
117_T 238_T 1.551 0.99
152_V 210_A 1.534 0.99
19_T 219_F 1.528 0.99
140_L 144_I 1.523 0.99
48_L 153_I 1.51 0.99
55_S 112_A 1.486 0.99
124_R 222_Y 1.469 0.99
159_T 163_V 1.447 0.99
96_L 167_I 1.438 0.99
128_Q 243_S 1.434 0.99
27_L 215_W 1.433 0.99
64_V 169_G 1.418 0.99
47_Q 147_R 1.403 0.99
171_S 186_W 1.39 0.99
229_A 233_R 1.37 0.98
70_L 94_S 1.365 0.98
78_L 90_L 1.357 0.98
212_T 216_I 1.322 0.98
79_T 84_E 1.309 0.98
10_G 14_I 1.306 0.98
163_V 202_C 1.3 0.98
111_R 235_T 1.295 0.98
61_V 245_A 1.29 0.98
104_A 162_F 1.286 0.97
5_A 8_S 1.284 0.97
212_T 245_A 1.276 0.97
74_G 90_L 1.271 0.97
124_R 223_D 1.253 0.97
41_A 45_V 1.253 0.97
211_I 215_W 1.248 0.97
61_V 244_L 1.244 0.97
8_S 12_K 1.24 0.97
56_M 161_I 1.212 0.96
209_F 250_D 1.207 0.96
217_S 242_S 1.194 0.96
7_A 11_H 1.19 0.95
26_M 219_F 1.187 0.95
29_N 33_G 1.181 0.95
171_S 175_V 1.176 0.95
5_A 9_L 1.175 0.95
155_L 159_T 1.172 0.95
203_L 207_V 1.16 0.95
4_N 7_A 1.155 0.94
204_I 257_M 1.148 0.94
128_Q 137_V 1.145 0.94
105_A 246_V 1.14 0.94
196_R 200_V 1.139 0.94
227_T 231_I 1.13 0.94
159_T 202_C 1.119 0.93
108_F 155_L 1.118 0.93
39_K 44_L 1.116 0.93
132_M 210_A 1.111 0.93
13_G 16_T 1.111 0.93
22_R 223_D 1.105 0.93
132_M 142_R 1.105 0.93
152_V 211_I 1.104 0.92
47_Q 50_N 1.103 0.92
105_A 114_S 1.101 0.92
108_F 213_V 1.1 0.92
44_L 48_L 1.097 0.92
133_E 139_P 1.096 0.92
87_L 174_G 1.094 0.92
62_S 128_Q 1.092 0.92
175_V 182_S 1.086 0.92
100_G 163_V 1.083 0.91
91_V 170_G 1.078 0.91
26_M 144_I 1.077 0.91
239_V 250_D 1.075 0.91
98_E 209_F 1.074 0.91
27_L 211_I 1.07 0.91
125_A 231_I 1.07 0.91
60_V 88_G 1.066 0.91
65_F 102_V 1.059 0.90
220_N 223_D 1.049 0.90
125_A 227_T 1.046 0.90
14_I 18_R 1.044 0.89
10_G 13_G 1.044 0.89
200_V 204_I 1.041 0.89
105_A 250_D 1.039 0.89
205_K 209_F 1.035 0.89
109_A 254_T 1.033 0.89
253_L 257_M 1.021 0.88
122_L 125_A 1.019 0.88
129_L 143_V 1.011 0.87
25_L 29_N 1.008 0.87
92_A 193_V 1.003 0.87
108_F 112_A 1 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2zy9A20.53087.50.967Contact Map0.113
3arcT20.09622.50.974Contact Map0.435
1h2sB10.21541.50.977Contact Map0.099
2ls2A10.08851.50.977Contact Map0
1rh5C10.20381.40.977Contact Map0.024
1a93B10.05771.30.978Contact Map0
3rlfG10.80381.10.979Contact Map0.086
2kncB10.130810.979Contact Map0
4h44G10.11540.90.98Contact Map0.753
2nwlA30.41150.90.98Contact Map0.17
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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