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OPENSEQ.org
CPTB - Antitoxin CptB
UniProt: P64559 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13075
Length: 88 (80)
Sequences: 310
Seq/Len: 3.88
CPTB
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
27_F 35_L 3.277 1.00
13_C 43_F 2.81 1.00
39_E 71_M 2.618 1.00
39_E 75_L 2.221 1.00
17_M 55_F 2.146 1.00
45_R 66_D 1.918 1.00
57_W 73_V 1.546 0.98
52_P 61_H 1.518 0.98
49_C 57_W 1.462 0.97
10_H 29_E 1.447 0.97
63_K 70_E 1.439 0.96
63_K 74_R 1.427 0.96
66_D 69_L 1.388 0.95
37_D 40_K 1.377 0.95
27_F 79_R 1.363 0.95
74_R 78_T 1.332 0.94
67_A 74_R 1.283 0.92
56_N 62_G 1.277 0.92
52_P 59_M 1.254 0.91
24_I 28_F 1.252 0.91
6_K 33_D 1.185 0.87
32_Y 40_K 1.164 0.86
68_E 71_M 1.164 0.86
9_I 28_F 1.136 0.84
25_M 29_E 1.134 0.84
39_E 67_A 1.13 0.84
70_E 74_R 1.124 0.83
18_R 35_L 1.111 0.82
74_R 77_Q 1.11 0.82
69_L 73_V 1.1 0.82
18_R 23_S 1.08 0.80
26_P 55_F 1.074 0.79
18_R 27_F 1.073 0.79
58_L 77_Q 1.048 0.77
34_S 41_R 1.026 0.75
38_D 68_E 1.02 0.74
22_I 80_N 1.013 0.74
25_M 47_L 1.005 0.73
7_A 25_M 1.003 0.73
34_S 78_T 1.002 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1x6iA2199.90.183Contact Map0.621
2jr5A1199.90.201Contact Map0.288
1puzA10.897799.90.227Contact Map0.407
2lm4A10.988699.90.278Contact Map0.42
3eukL20.96598.40.917Contact Map0.076
3euhC40.96597.50.919Contact Map0.181
3h0gE20.988670.92Contact Map0.11
1dzfA10.95456.60.921Contact Map0.186
1n1fA10.40915.70.923Contact Map0.133
1olmA20.69325.60.924Contact Map0.157
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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