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OPENSEQ.org
GMHB - D,D-heptose 1,7-bisphosphate phosphatase
UniProt: P63228 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11736
Length: 191 (182)
Sequences: 1060
Seq/Len: 5.82
GMHB
Paralog alert: 0.45 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
94_H 107_C 3.943 1.00
90_Y 123_Y 2.985 1.00
121_R 128_M 2.974 1.00
94_H 109_C 2.832 1.00
18_V 30_E 2.766 1.00
39_M 49_L 2.719 1.00
8_I 42_L 2.622 1.00
144_A 151_T 2.471 1.00
43_K 84_V 2.164 1.00
88_G 123_Y 2.145 1.00
43_K 49_L 2.097 1.00
92_C 107_C 1.95 1.00
40_R 44_K 1.936 1.00
90_Y 120_A 1.93 1.00
88_G 124_L 1.919 1.00
58_I 68_F 1.821 1.00
65_E 69_E 1.79 1.00
31_F 78_S 1.782 1.00
119_S 123_Y 1.761 1.00
114_P 118_L 1.754 1.00
56_S 60_R 1.737 1.00
59_A 95_H 1.728 1.00
117_L 133_M 1.698 1.00
64_T 67_Q 1.691 1.00
17_N 29_F 1.674 1.00
133_M 143_A 1.67 1.00
57_G 63_F 1.648 1.00
50_V 124_L 1.641 1.00
78_S 81_D 1.638 1.00
39_M 43_K 1.635 1.00
68_F 72_T 1.621 0.99
25_E 28_N 1.62 0.99
16_I 39_M 1.594 0.99
92_C 109_C 1.566 0.99
43_K 87_D 1.529 0.99
114_P 146_A 1.5 0.99
24_H 28_N 1.457 0.99
9_F 131_S 1.446 0.99
117_L 143_A 1.444 0.99
50_V 120_A 1.432 0.98
20_H 23_V 1.423 0.98
31_F 36_I 1.384 0.98
75_M 89_I 1.368 0.98
174_N 178_D 1.343 0.97
51_V 86_L 1.316 0.97
173_L 179_L 1.314 0.97
76_D 89_I 1.301 0.97
138_L 142_Q 1.275 0.96
35_V 38_A 1.271 0.96
179_L 183_I 1.27 0.96
101_E 104_R 1.264 0.96
65_E 91_Y 1.259 0.96
9_F 50_V 1.253 0.96
43_K 79_L 1.237 0.95
155_V 158_G 1.202 0.94
74_W 78_S 1.193 0.94
106_V 113_H 1.186 0.94
19_D 56_S 1.185 0.94
20_H 30_E 1.184 0.93
39_M 84_V 1.184 0.93
127_D 130_A 1.182 0.93
52_V 133_M 1.175 0.93
48_A 87_D 1.169 0.93
19_D 23_V 1.163 0.93
93_P 109_C 1.162 0.93
114_P 143_A 1.15 0.92
41_E 181_Q 1.147 0.92
59_A 98_G 1.147 0.92
6_P 130_A 1.147 0.92
98_G 104_R 1.141 0.92
49_L 84_V 1.117 0.91
7_A 126_I 1.111 0.90
79_L 84_V 1.11 0.90
51_V 89_I 1.095 0.89
128_M 131_S 1.093 0.89
154_L 158_G 1.091 0.89
56_S 62_K 1.072 0.88
40_R 84_V 1.065 0.88
74_W 77_W 1.056 0.87
36_I 79_L 1.056 0.87
66_A 69_E 1.052 0.87
34_G 37_D 1.046 0.86
126_I 131_S 1.042 0.86
26_I 29_F 1.037 0.86
90_Y 119_S 1.035 0.86
117_L 147_A 1.029 0.85
50_V 88_G 1.029 0.85
52_V 117_L 1.024 0.85
156_R 174_N 1.024 0.85
180_P 184_K 1.012 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3l8hA40.91621000.525Contact Map0.82
2o2xA10.98431000.546Contact Map0.763
2gmwA20.99481000.557Contact Map0.832
2fprA20.85861000.59Contact Map0.776
3zvlA10.916299.90.631Contact Map0.587
2ho4A20.921599.90.664Contact Map0.53
3ib6A40.879699.90.684Contact Map0.644
2odaA20.837799.90.695Contact Map0.526
4jdpA20.916299.80.699Contact Map0.698
2ymmA40.842999.80.707Contact Map0.643
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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