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OPENSEQ.org

RL5 - 50S ribosomal protein L5
UniProt: P62399 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10868
Length: 179 (179)
Sequences: 1319
Seq/Len: 7.37

RL5
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
3_K 101_E 4.601 1.00
6_D 10_D 4.338 1.00
36_L 61_S 3.809 1.00
19_E 168_A 3.142 1.00
7_Y 11_E 2.911 1.00
129_S 155_T 2.828 1.00
108_V 111_I 2.812 1.00
34_I 100_F 2.792 1.00
13_V 28_V 2.698 1.00
103_L 130_M 2.463 1.00
31_V 156_I 2.422 1.00
132_V 137_I 2.415 1.00
22_Y 165_E 2.182 1.00
57_L 87_C 2.181 1.00
15_K 18_T 2.165 1.00
171_A 179_K 2.147 1.00
27_Q 161_K 2.086 1.00
7_Y 12_V 2.085 1.00
142_D 145_K 2.077 1.00
58_A 64_K 2.024 1.00
17_M 28_V 2.005 1.00
117_L 175_F 1.997 1.00
35_T 157_T 1.948 1.00
97_W 173_F 1.867 1.00
168_A 172_A 1.845 1.00
5_H 9_K 1.816 1.00
58_A 65_P 1.783 1.00
101_E 105_T 1.768 1.00
124_G 163_D 1.766 1.00
12_V 173_F 1.713 1.00
162_S 165_E 1.616 1.00
14_K 18_T 1.586 1.00
19_E 164_E 1.572 1.00
100_F 156_I 1.55 1.00
98_E 102_R 1.53 1.00
40_V 53_A 1.522 0.99
119_A 179_K 1.517 0.99
15_K 172_A 1.513 0.99
88_K 153_D 1.494 0.99
22_Y 162_S 1.485 0.99
11_E 15_K 1.452 0.99
168_A 171_A 1.407 0.99
36_L 152_L 1.37 0.99
167_R 171_A 1.363 0.99
69_K 84_P 1.361 0.99
34_I 173_F 1.359 0.99
79_I 85_I 1.353 0.99
38_M 53_A 1.34 0.98
70_A 73_S 1.333 0.98
70_A 82_G 1.327 0.98
119_A 167_R 1.32 0.98
9_K 13_V 1.291 0.98
17_M 25_V 1.285 0.98
2_A 98_E 1.284 0.98
100_F 104_I 1.28 0.98
136_I 149_V 1.271 0.98
31_V 34_I 1.269 0.97
68_T 88_K 1.259 0.97
164_E 167_R 1.252 0.97
44_I 85_I 1.245 0.97
32_E 159_T 1.224 0.97
55_A 59_A 1.217 0.97
38_M 57_L 1.216 0.97
73_S 81_Q 1.2 0.96
15_K 19_E 1.172 0.95
8_Y 13_V 1.168 0.95
117_L 130_M 1.164 0.95
147_D 150_R 1.159 0.95
14_K 17_M 1.156 0.95
108_V 117_L 1.154 0.95
54_A 67_I 1.15 0.95
136_I 143_Y 1.146 0.95
52_N 147_D 1.142 0.95
34_I 104_I 1.141 0.95
31_V 100_F 1.127 0.94
25_V 28_V 1.1 0.93
54_A 58_A 1.092 0.93
5_H 94_E 1.09 0.93
123_D 127_N 1.078 0.92
2_A 94_E 1.054 0.91
40_V 50_L 1.053 0.91
61_S 66_L 1.052 0.91
19_E 172_A 1.049 0.91
1_M 6_D 1.028 0.89
121_S 153_D 1.024 0.89
158_T 166_G 1.01 0.88
45_A 76_G 1.006 0.88
50_L 87_C 1 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4kixF111000.049Contact Map0.697
3bboH111000.052Contact Map0.579
1iq4A211000.053Contact Map0.795
1mjiA211000.058Contact Map0.788
3j21E10.91621000.298Contact Map0.473
1vq8D10.87151000.305Contact Map0.565
3iz5E10.86031000.33Contact Map0.408
3j3bJ10.86591000.331Contact Map0.719
3zf7L10.88831000.339Contact Map0.601
4a17D10.84921000.344Contact Map0.596

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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