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OPENSEQ.org
SYH - Histidine--tRNA ligase
UniProt: P60906 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10453
Length: 424 (417)
Sequences: 2848
Seq/Len: 6.83
SYH
Paralog alert: 0.25 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
107_Y 129_G 3.706 1.00
384_A 402_L 3.562 1.00
293_E 299_A 3.512 1.00
164_E 254_N 3.46 1.00
245_E 251_Y 3.453 1.00
396_T 409_A 2.715 1.00
11_M 46_V 2.606 1.00
33_L 128_L 2.436 1.00
71_E 75_G 2.413 1.00
398_V 407_Q 2.388 1.00
173_A 230_D 2.338 1.00
399_V 418_H 2.306 1.00
348_A 360_L 2.298 1.00
390_S 394_N 2.258 1.00
179_D 183_A 2.256 1.00
148_T 271_W 2.229 1.00
28_T 154_A 2.2 1.00
237_F 253_V 2.159 1.00
389_E 393_A 2.154 1.00
31_N 154_A 2.146 1.00
35_S 154_A 2.145 1.00
411_A 414_S 2.135 1.00
368_N 371_K 2.118 1.00
414_S 417_A 2.098 1.00
170_S 230_D 2.066 1.00
69_T 77_S 2.056 1.00
394_N 409_A 2.045 1.00
36_Y 150_R 1.989 1.00
401_D 404_S 1.963 1.00
150_R 349_E 1.96 1.00
49_T 79_T 1.953 1.00
27_G 31_N 1.935 1.00
390_S 393_A 1.918 1.00
23_Q 40_E 1.916 1.00
142_A 243_L 1.908 1.00
185_L 207_V 1.897 1.00
194_E 197_K 1.892 1.00
408_T 418_H 1.88 1.00
350_R 412_Q 1.876 1.00
104_R 361_M 1.869 1.00
29_L 151_W 1.862 1.00
410_V 415_V 1.852 1.00
196_C 210_S 1.847 1.00
132_V 140_I 1.826 1.00
333_L 348_A 1.824 1.00
49_T 69_T 1.81 1.00
193_D 196_C 1.809 1.00
8_I 46_V 1.806 1.00
130_C 147_L 1.791 1.00
81_R 109_G 1.775 1.00
343_A 346_A 1.775 1.00
180_A 228_Y 1.762 1.00
18_E 317_Q 1.761 1.00
26_E 42_R 1.743 1.00
34_G 106_W 1.732 1.00
230_D 233_S 1.731 1.00
8_I 11_M 1.723 1.00
84_G 129_G 1.718 1.00
373_F 386_V 1.71 1.00
238_A 242_K 1.709 1.00
418_H 421_T 1.703 1.00
32_V 154_A 1.7 1.00
148_T 283_C 1.698 1.00
110_P 124_Q 1.69 1.00
89_V 292_V 1.689 1.00
24_R 28_T 1.689 1.00
84_G 107_Y 1.673 1.00
388_G 391_E 1.669 1.00
76_D 114_H 1.633 1.00
398_V 409_A 1.631 1.00
198_R 202_T 1.608 1.00
346_A 350_R 1.581 1.00
173_A 233_S 1.571 1.00
242_K 342_S 1.569 1.00
241_C 245_E 1.563 1.00
385_V 397_A 1.547 0.99
170_S 173_A 1.542 0.99
396_T 411_A 1.541 0.99
186_E 201_Y 1.535 0.99
339_D 389_E 1.53 0.99
231_E 235_E 1.528 0.99
38_Y 132_V 1.516 0.99
30_K 40_E 1.509 0.99
193_D 210_S 1.502 0.99
72_D 76_D 1.496 0.99
189_K 197_K 1.49 0.99
153_R 161_V 1.487 0.99
241_C 251_Y 1.483 0.99
382_R 401_D 1.482 0.99
246_S 342_S 1.47 0.99
9_R 116_R 1.455 0.99
88_C 129_G 1.451 0.99
183_A 186_E 1.449 0.99
397_A 412_Q 1.438 0.99
45_I 124_Q 1.434 0.99
330_D 358_V 1.432 0.99
163_L 271_W 1.416 0.99
146_M 247_A 1.401 0.99
144_L 303_V 1.389 0.99
330_D 359_K 1.377 0.98
162_T 274_N 1.374 0.98
241_C 253_V 1.37 0.98
29_L 128_L 1.362 0.98
348_A 362_T 1.344 0.98
46_V 78_L 1.34 0.98
170_S 233_S 1.339 0.98
35_S 358_V 1.337 0.98
337_G 389_E 1.335 0.98
40_E 106_W 1.329 0.98
49_T 77_S 1.324 0.98
84_G 111_M 1.322 0.98
128_L 309_L 1.317 0.98
45_I 109_G 1.308 0.98
125_F 306_A 1.299 0.98
164_E 272_V 1.295 0.97
162_T 252_T 1.294 0.97
126_H 310_E 1.292 0.97
45_I 112_F 1.288 0.97
414_S 418_H 1.276 0.97
74_N 114_H 1.275 0.97
43_L 87_G 1.272 0.97
373_F 377_D 1.269 0.97
25_I 313_V 1.265 0.97
331_I 358_V 1.263 0.97
337_G 340_T 1.261 0.97
335_A 372_Q 1.259 0.97
23_Q 30_K 1.251 0.97
45_I 110_P 1.243 0.97
21_I 317_Q 1.24 0.96
149_A 163_L 1.24 0.96
200_M 207_V 1.229 0.96
73_R 114_H 1.226 0.96
350_R 413_D 1.218 0.96
20_A 39_S 1.218 0.96
164_E 252_T 1.204 0.96
161_V 271_W 1.203 0.96
383_V 419_L 1.203 0.96
31_N 35_S 1.2 0.96
34_G 359_K 1.192 0.95
343_A 392_V 1.165 0.95
69_T 79_T 1.155 0.94
149_A 250_A 1.155 0.94
193_D 215_V 1.155 0.94
239_G 243_L 1.153 0.94
340_T 343_A 1.152 0.94
112_F 124_Q 1.15 0.94
12_N 310_E 1.147 0.94
9_R 117_P 1.145 0.94
331_I 360_L 1.145 0.94
210_S 215_V 1.145 0.94
8_I 78_L 1.142 0.94
234_R 238_A 1.142 0.94
160_H 275_S 1.137 0.94
88_C 107_Y 1.135 0.93
308_G 311_R 1.131 0.93
371_K 374_A 1.129 0.93
185_L 219_L 1.128 0.93
160_H 274_N 1.126 0.93
223_P 238_A 1.124 0.93
335_A 344_A 1.121 0.93
7_A 94_E 1.112 0.93
239_G 242_K 1.105 0.92
334_V 384_A 1.104 0.92
334_V 369_F 1.102 0.92
149_A 153_R 1.091 0.92
235_E 238_A 1.089 0.92
35_S 150_R 1.086 0.91
399_V 415_V 1.082 0.91
242_K 246_S 1.081 0.91
397_A 410_V 1.08 0.91
195_D 198_R 1.08 0.91
238_A 241_C 1.076 0.91
186_E 189_K 1.074 0.91
141_D 144_L 1.069 0.91
84_G 109_G 1.069 0.91
123_R 260_G 1.069 0.91
46_V 80_L 1.069 0.91
374_A 378_K 1.058 0.90
377_D 402_L 1.057 0.90
27_G 30_K 1.054 0.90
370_K 374_A 1.049 0.89
350_R 353_D 1.045 0.89
235_E 239_G 1.044 0.89
189_K 200_M 1.038 0.89
395_G 413_D 1.033 0.88
232_E 235_E 1.031 0.88
28_T 32_V 1.027 0.88
89_V 133_F 1.026 0.88
290_G 299_A 1.025 0.88
130_C 144_L 1.023 0.88
271_W 283_C 1.022 0.88
367_G 371_K 1.019 0.87
149_A 161_V 1.013 0.87
107_Y 131_E 1.011 0.87
382_R 403_R 1.011 0.87
173_A 266_R 1.008 0.87
28_T 31_N 1.007 0.87
152_W 283_C 1.005 0.87
343_A 412_Q 1.003 0.86
162_T 250_A 1 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1httA40.99061000.214Contact Map0.796
1h4vB10.98581000.215Contact Map0.639
4e51A20.99061000.223Contact Map0.726
1qe0A20.97881000.246Contact Map0.785
3od1A20.88441000.279Contact Map0.71
1wu7A20.95281000.287Contact Map0.698
3lc0A10.96931000.289Contact Map0.539
4g84A20.95991000.292Contact Map0.705
4g85A20.96231000.295Contact Map0.695
3netA20.9671000.295Contact Map0.716
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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