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OPENSEQ.org
LIPA - Lipoyl synthase
UniProt: P60716 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11306
Length: 321 (295)
Sequences: 1180
Seq/Len: 4.00
LIPA
Paralog alert: 0.07 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
90_L 111_P 5.562 1.00
249_M 260_L 4.592 1.00
277_R 283_E 3.652 1.00
199_P 212_N 3.419 1.00
169_V 191_F 3.355 1.00
250_R 294_M 3.316 1.00
200_R 244_E 3.279 1.00
211_Y 251_D 3.177 1.00
285_D 288_K 3.078 1.00
236_V 262_L 3.074 1.00
288_K 292_L 2.954 1.00
222_K 258_T 2.855 1.00
242_N 286_E 2.843 1.00
155_A 158_E 2.838 1.00
114_N 117_V 2.801 1.00
147_Q 151_D 2.676 1.00
119_L 152_C 2.676 1.00
60_R 69_E 2.61 1.00
246_I 290_E 2.495 1.00
290_E 293_A 2.433 1.00
252_L 257_V 2.38 1.00
242_N 283_E 2.374 1.00
124_A 159_K 2.369 1.00
242_N 287_M 2.34 1.00
130_Y 164_K 2.296 1.00
160_S 163_I 2.281 1.00
216_K 219_E 2.242 1.00
89_I 133_I 2.194 1.00
290_E 294_M 2.137 1.00
302_G 305_V 2.124 1.00
249_M 291_A 2.072 1.00
232_S 252_L 2.047 1.00
205_V 273_L 2.013 1.00
219_E 223_E 1.999 1.00
135_S 170_P 1.911 1.00
289_A 293_A 1.879 1.00
92_A 104_A 1.797 0.99
291_A 299_A 1.762 0.99
216_K 220_R 1.756 0.99
153_I 167_T 1.736 0.99
67_V 71_A 1.734 0.99
117_V 121_Q 1.723 0.99
220_R 223_E 1.719 0.99
250_R 254_R 1.715 0.99
133_I 156_I 1.714 0.99
218_L 257_V 1.713 0.99
118_K 121_Q 1.712 0.99
279_V 287_M 1.704 0.99
199_P 247_E 1.674 0.99
181_D 224_A 1.667 0.99
199_P 202_Y 1.664 0.99
130_Y 190_V 1.663 0.99
117_V 155_A 1.658 0.99
153_I 186_T 1.646 0.99
144_G 179_A 1.644 0.99
212_N 216_K 1.634 0.99
253_R 256_G 1.569 0.98
56_K 69_E 1.564 0.98
117_V 159_K 1.524 0.98
150_A 154_T 1.519 0.98
191_F 221_F 1.498 0.98
93_I 104_A 1.484 0.97
78_E 309_Y 1.475 0.97
172_F 183_L 1.453 0.97
100_F 209_A 1.438 0.97
283_E 287_M 1.437 0.97
157_R 165_I 1.397 0.96
88_M 103_V 1.393 0.96
51_R 54_G 1.387 0.96
82_H 312_D 1.383 0.96
175_R 179_A 1.37 0.95
72_S 102_D 1.365 0.95
199_P 248_V 1.362 0.95
253_R 296_F 1.352 0.95
62_N 122_T 1.348 0.95
90_L 148_H 1.331 0.94
52_I 80_F 1.326 0.94
221_F 228_I 1.325 0.94
181_D 185_A 1.311 0.94
187_P 225_H 1.309 0.93
285_D 289_A 1.304 0.93
180_L 220_R 1.294 0.93
146_A 182_I 1.287 0.93
247_E 251_D 1.275 0.92
135_S 149_F 1.275 0.92
181_D 220_R 1.272 0.92
184_T 221_F 1.264 0.92
147_Q 182_I 1.263 0.92
253_R 294_M 1.241 0.91
62_N 125_D 1.241 0.91
175_R 178_R 1.238 0.91
177_D 220_R 1.218 0.90
123_I 160_S 1.211 0.89
114_N 118_K 1.2 0.89
246_I 294_M 1.199 0.89
80_F 105_H 1.194 0.89
151_D 155_A 1.19 0.88
286_E 290_E 1.187 0.88
269_S 272_H 1.186 0.88
70_E 92_A 1.18 0.88
242_N 246_I 1.176 0.88
99_P 273_L 1.173 0.87
57_A 61_K 1.166 0.87
178_R 181_D 1.165 0.87
202_Y 207_P 1.151 0.86
52_I 76_L 1.148 0.86
283_E 286_E 1.146 0.86
241_T 247_E 1.132 0.85
250_R 290_E 1.128 0.84
211_Y 247_E 1.11 0.83
204_Q 276_Q 1.108 0.83
249_M 294_M 1.104 0.83
56_K 60_R 1.098 0.82
60_R 70_E 1.098 0.82
156_I 163_I 1.08 0.81
193_H 214_S 1.079 0.81
151_D 154_T 1.078 0.81
184_T 225_H 1.07 0.80
123_I 131_V 1.069 0.80
155_A 159_K 1.069 0.80
288_K 301_C 1.06 0.79
14_R 17_D 1.053 0.78
279_V 283_E 1.052 0.78
157_R 188_P 1.049 0.78
246_I 293_A 1.048 0.78
184_T 224_A 1.04 0.77
183_L 187_P 1.021 0.75
43_I 304_F 1.019 0.75
202_Y 210_D 1.016 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3iixA10.86699.70.885Contact Map0.492
1r30A20.89199.60.886Contact Map0.477
3t7vA10.862999.60.886Contact Map0.479
2qgqA80.735299.50.897Contact Map0.565
1oltA10.856799.40.904Contact Map0.398
4jc0A20.981399.30.908Contact Map0.453
2yx0A10.8941990.919Contact Map0.459
2z2uA10.806998.80.925Contact Map0.475
3c8fA10.691698.80.925Contact Map0.496
1tv8A20.732198.60.929Contact Map0.439
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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