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OPENSEQ.org

SPEB - Agmatinase
UniProt: P60651 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10960
Length: 306 (292)
Sequences: 2321
Seq/Len: 7.95

SPEB
Paralog alert: 0.47 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
59_I 122_F 4.216 1.00
110_E 138_K 3.438 1.00
234_L 288_A 3.294 1.00
57_A 90_D 3.293 1.00
229_F 255_A 3.145 1.00
133_L 170_A 3.114 1.00
239_A 285_T 3.101 1.00
106_Q 134_R 2.922 1.00
231_I 242_T 2.469 1.00
106_Q 138_K 2.252 1.00
60_R 87_D 2.208 1.00
60_R 90_D 2.157 1.00
39_G 60_R 2.131 1.00
231_I 275_V 2.13 1.00
36_V 117_K 2.059 1.00
59_I 289_A 2.046 1.00
231_I 239_A 1.971 1.00
189_E 193_D 1.968 1.00
109_A 121_S 1.966 1.00
227_L 267_I 1.956 1.00
197_T 215_Q 1.928 1.00
144_A 223_M 1.875 1.00
234_L 255_A 1.869 1.00
103_E 107_A 1.859 1.00
270_M 296_M 1.839 1.00
106_Q 135_A 1.825 1.00
183_Q 186_I 1.798 1.00
272_V 293_A 1.797 1.00
38_T 112_L 1.783 1.00
130_L 134_R 1.765 1.00
39_G 89_G 1.765 1.00
122_F 293_A 1.747 1.00
43_D 53_R 1.738 1.00
275_V 289_A 1.732 1.00
87_D 90_D 1.722 1.00
113_L 135_A 1.709 1.00
148_F 233_C 1.701 1.00
40_V 121_S 1.69 1.00
207_R 215_Q 1.686 1.00
211_D 214_A 1.676 1.00
163_H 243_G 1.657 1.00
252_S 288_A 1.635 1.00
241_G 280_D 1.621 1.00
231_I 272_V 1.618 1.00
156_A 169_T 1.614 1.00
163_H 244_T 1.608 1.00
205_N 253_D 1.601 1.00
169_T 172_K 1.594 1.00
214_A 218_Q 1.583 1.00
275_V 285_T 1.581 1.00
148_F 258_L 1.579 1.00
40_V 105_L 1.574 1.00
100_E 104_K 1.571 1.00
120_L 270_M 1.554 1.00
130_L 173_E 1.529 1.00
233_C 250_L 1.521 1.00
209_V 213_I 1.515 1.00
106_Q 110_E 1.472 0.99
109_A 132_L 1.455 0.99
226_Y 269_G 1.439 0.99
30_D 115_A 1.432 0.99
168_Y 172_K 1.431 0.99
105_L 121_S 1.429 0.99
59_I 275_V 1.427 0.99
121_S 132_L 1.426 0.99
233_C 255_A 1.425 0.99
39_G 87_D 1.408 0.99
168_Y 190_F 1.405 0.99
142_K 223_M 1.396 0.99
182_V 197_T 1.392 0.99
113_L 136_H 1.39 0.99
197_T 219_I 1.375 0.99
207_R 211_D 1.371 0.99
39_G 90_D 1.364 0.99
60_R 89_G 1.351 0.99
49_R 279_Y 1.339 0.99
143_M 268_V 1.333 0.99
46_T 52_G 1.332 0.99
100_E 103_E 1.331 0.99
57_A 61_Q 1.319 0.98
260_R 295_E 1.317 0.98
190_F 194_N 1.302 0.98
102_S 127_F 1.299 0.98
205_N 254_R 1.296 0.98
38_T 108_H 1.288 0.98
251_T 254_R 1.287 0.98
50_A 53_R 1.286 0.98
58_A 286_A 1.285 0.98
210_D 214_A 1.284 0.98
40_V 128_V 1.278 0.98
238_F 252_S 1.276 0.98
40_V 101_M 1.274 0.98
134_R 173_E 1.271 0.98
135_A 139_H 1.256 0.98
38_T 109_A 1.252 0.98
43_D 51_G 1.25 0.98
208_S 212_V 1.247 0.98
114_A 139_H 1.24 0.97
110_E 114_A 1.233 0.97
108_H 111_K 1.215 0.97
50_A 54_H 1.214 0.97
163_H 242_T 1.208 0.97
35_W 297_L 1.202 0.97
146_V 262_L 1.2 0.97
128_V 273_V 1.188 0.96
118_R 270_M 1.171 0.96
136_H 143_M 1.168 0.96
182_V 219_I 1.165 0.96
206_D 257_K 1.165 0.96
38_T 121_S 1.157 0.96
186_I 198_V 1.156 0.96
167_F 183_Q 1.144 0.95
187_R 235_D 1.139 0.95
133_L 145_L 1.13 0.95
229_F 292_L 1.128 0.95
149_D 153_D 1.125 0.95
18_G 24_M 1.118 0.95
187_R 236_P 1.112 0.94
88_C 112_L 1.106 0.94
237_A 252_S 1.104 0.94
217_K 261_G 1.103 0.94
214_A 261_G 1.102 0.94
36_V 88_C 1.098 0.94
37_I 122_F 1.095 0.94
43_D 52_G 1.077 0.93
101_M 105_L 1.07 0.93
152_T 183_Q 1.069 0.93
121_S 128_V 1.066 0.92
112_L 119_M 1.065 0.92
34_D 84_N 1.065 0.92
213_I 258_L 1.062 0.92
180_H 223_M 1.058 0.92
118_R 300_Q 1.056 0.92
136_H 269_G 1.053 0.92
36_V 112_L 1.051 0.92
176_I 181_S 1.048 0.92
156_A 168_Y 1.039 0.91
35_W 83_L 1.037 0.91
152_T 186_I 1.034 0.91
147_H 183_Q 1.02 0.90
184_I 216_V 1.017 0.90
52_G 276_A 1.013 0.90
145_L 176_I 1.012 0.90
55_G 122_F 1.007 0.89
295_E 298_Y 1.006 0.89
45_A 125_D 1.003 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gq6A30.98041000.135Contact Map0.732
3niqA20.98041000.143Contact Map0.781
4dz4A60.99021000.145Contact Map0.779
3nioA60.98691000.145Contact Map0.711
3m1rA60.97711000.155Contact Map0.773
1wohA60.9511000.172Contact Map0.696
4mykA10.96411000.177Contact Map0.77
2a0mA10.96411000.182Contact Map0.745
3pzlA30.9511000.213Contact Map0.749
1xfkA10.9511000.226Contact Map0.717

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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