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OPENSEQ.org

RL3 - 50S ribosomal protein L3
UniProt: P60438 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10866
Length: 209 (208)
Sequences: 1738
Seq/Len: 8.36

RL3
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
164_Q 167_N 4.856 1.00
27_I 189_V 3.981 1.00
6_G 27_I 3.434 1.00
113_S 170_V 3.408 1.00
91_T 94_Q 3.394 1.00
110_T 169_R 3.135 1.00
119_A 165_M 2.947 1.00
130_Q 136_N 2.641 1.00
35_T 79_L 2.61 1.00
56_K 59_R 2.602 1.00
27_I 193_V 2.438 1.00
122_V 129_T 2.41 1.00
150_Q 153_G 2.3 1.00
40_L 46_R 2.295 1.00
65_A 69_A 2.262 1.00
36_Q 67_H 2.247 1.00
193_V 201_L 2.148 1.00
129_T 132_A 2.143 1.00
187_L 203_V 2.115 1.00
116_K 165_M 2.103 1.00
112_T 169_R 2.055 1.00
121_T 143_P 2.014 1.00
106_K 176_D 1.974 1.00
154_K 157_K 1.967 1.00
139_S 142_V 1.966 1.00
149_N 153_G 1.945 1.00
103_D 179_R 1.873 1.00
176_D 190_K 1.866 1.00
49_Q 67_H 1.862 1.00
7_K 28_E 1.846 1.00
136_N 139_S 1.833 1.00
26_V 188_L 1.812 1.00
109_V 203_V 1.796 1.00
181_D 184_R 1.671 1.00
86_E 89_E 1.66 1.00
16_T 20_V 1.655 1.00
118_F 162_A 1.617 1.00
54_A 74_E 1.595 1.00
173_Q 208_K 1.587 1.00
146_I 155_V 1.583 1.00
126_N 165_M 1.543 1.00
130_Q 139_S 1.502 1.00
169_R 202_I 1.464 0.99
107_V 203_V 1.456 0.99
196_A 199_S 1.45 0.99
136_N 142_V 1.446 0.99
12_T 26_V 1.43 0.99
4_L 29_V 1.426 0.99
130_Q 142_V 1.415 0.99
60_V 68_F 1.395 0.99
14_I 188_L 1.393 0.99
4_L 96_I 1.391 0.99
37_V 92_V 1.381 0.99
61_T 64_E 1.378 0.99
78_G 200_D 1.377 0.99
13_R 21_S 1.376 0.99
110_T 204_K 1.376 0.99
127_F 160_K 1.372 0.99
121_T 162_A 1.265 0.98
31_A 185_N 1.238 0.98
55_K 60_V 1.236 0.98
108_D 173_Q 1.235 0.98
111_G 194_P 1.235 0.98
90_F 94_Q 1.206 0.97
99_E 182_A 1.2 0.97
54_A 76_G 1.184 0.97
102_A 105_K 1.183 0.97
172_V 175_L 1.18 0.97
119_A 123_K 1.164 0.96
125_W 162_A 1.162 0.96
16_T 176_D 1.157 0.96
30_E 52_T 1.153 0.96
173_Q 204_K 1.142 0.96
174_S 206_A 1.124 0.95
64_E 67_H 1.119 0.95
5_V 78_G 1.107 0.95
28_E 185_N 1.102 0.94
48_I 90_F 1.102 0.94
50_V 96_I 1.085 0.94
124_R 163_G 1.08 0.94
57_A 65_A 1.077 0.94
80_W 202_I 1.072 0.93
116_K 119_A 1.06 0.93
114_K 196_A 1.057 0.93
143_P 146_I 1.056 0.93
68_F 73_V 1.049 0.92
172_V 192_A 1.045 0.92
123_K 165_M 1.043 0.92
111_G 199_S 1.034 0.92
64_E 68_F 1.027 0.91
37_V 91_T 1.025 0.91
113_S 168_E 1.022 0.91
111_G 201_L 1.021 0.91
36_Q 43_D 1.018 0.91
132_A 140_H 1.015 0.91
50_V 82_F 1.009 0.90
146_I 161_M 1.004 0.90
143_P 161_M 1.003 0.90
189_V 193_V 1.001 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4kixD11100-0.007Contact Map0.701
3bboF10.99521000.003Contact Map0.454
3j3wD10.99041000.008Contact Map0.633
2ftcC10.99521000.016Contact Map0.036
3v2dE10.97611000.021Contact Map0.741
2zjrB10.97611000.021Contact Map0.71
1vq8B10.99521000.109Contact Map0.618
3j21C10.98561000.152Contact Map0.633
3iz5C10.98091000.169Contact Map0.592
3zf7f10.97611000.171Contact Map0.579

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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