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OPENSEQ.org

RL2 - 50S ribosomal protein L2
UniProt: P60422 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10865
Length: 273 (272)
Sequences: 1275
Seq/Len: 4.69

RL2
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_A 94_V 3.641 1.00
143_N 152_G 3.353 1.00
172_V 186_A 3.183 1.00
79_E 95_L 2.984 1.00
26_K 80_R 2.938 1.00
58_H 213_W 2.856 1.00
150_K 153_Q 2.853 1.00
139_S 192_L 2.841 1.00
53_H 219_T 2.835 1.00
164_I 172_V 2.787 1.00
223_T 240_F 2.777 1.00
72_D 189_R 2.769 1.00
141_V 164_I 2.68 1.00
111_K 114_D 2.647 1.00
155_A 162_V 2.597 1.00
37_N 60_Q 2.548 1.00
216_V 219_T 2.484 1.00
173_T 181_M 2.444 1.00
70_N 102_R 2.408 1.00
94_V 116_I 2.407 1.00
174_L 184_V 2.402 1.00
144_V 162_V 2.279 1.00
54_I 216_V 2.246 1.00
44_N 50_T 2.185 1.00
77_V 115_Q 2.179 1.00
129_T 189_R 2.17 1.00
141_V 174_L 2.149 1.00
170_A 185_E 2.149 1.00
88_S 200_H 2.069 1.00
108_K 198_A 2.055 1.00
110_L 116_I 1.991 1.00
205_L 214_R 1.977 1.00
72_D 118_S 1.968 1.00
211_A 214_R 1.956 1.00
122_A 130_L 1.924 1.00
166_A 173_T 1.924 1.00
105_L 143_N 1.914 1.00
194_E 198_A 1.908 1.00
40_S 54_I 1.88 1.00
131_P 134_N 1.872 1.00
9_T 13_R 1.856 1.00
90_N 196_G 1.832 1.00
51_T 219_T 1.819 1.00
242_K 245_V 1.816 1.00
251_Q 255_K 1.813 1.00
223_T 239_N 1.812 1.00
19_V 203_R 1.801 1.00
246_T 250_V 1.798 1.00
71_K 98_D 1.793 1.00
95_L 101_R 1.765 1.00
148_P 185_E 1.749 1.00
173_T 183_K 1.747 1.00
133_R 187_D 1.734 1.00
27_G 80_R 1.711 0.99
105_L 152_G 1.686 0.99
146_M 184_V 1.657 0.99
75_P 97_K 1.617 0.99
73_G 121_D 1.606 0.99
77_V 95_L 1.597 0.99
71_K 100_E 1.557 0.99
19_V 90_N 1.547 0.99
78_V 110_L 1.546 0.99
107_P 110_L 1.543 0.99
205_L 211_A 1.529 0.99
65_V 91_I 1.497 0.98
35_E 64_I 1.482 0.98
211_A 216_V 1.462 0.98
30_F 101_R 1.445 0.98
135_I 192_L 1.441 0.98
239_N 242_K 1.44 0.98
252_T 255_K 1.435 0.98
144_V 174_L 1.419 0.97
154_L 184_V 1.411 0.97
250_V 255_K 1.411 0.97
6_C 18_K 1.407 0.97
34_L 61_A 1.394 0.97
154_L 176_L 1.373 0.97
79_E 101_R 1.373 0.97
240_F 253_K 1.347 0.96
167_R 186_A 1.332 0.96
108_K 194_E 1.317 0.95
260_N 263_T 1.307 0.95
114_D 125_K 1.299 0.95
75_P 115_Q 1.272 0.94
119_G 130_L 1.271 0.94
73_G 119_G 1.26 0.94
243_H 253_K 1.217 0.92
53_H 216_V 1.194 0.91
54_I 219_T 1.183 0.91
185_E 266_F 1.182 0.91
74_I 97_K 1.177 0.90
147_K 150_K 1.169 0.90
3_V 17_V 1.168 0.90
240_F 243_H 1.163 0.90
24_L 27_G 1.157 0.89
80_R 112_A 1.155 0.89
223_T 243_H 1.154 0.89
13_R 16_V 1.15 0.89
232_H 245_V 1.14 0.88
15_H 204_V 1.128 0.88
25_H 81_L 1.127 0.88
246_T 253_K 1.124 0.87
92_A 106_A 1.12 0.87
2_A 20_V 1.117 0.87
119_G 122_A 1.112 0.87
264_D 270_R 1.11 0.86
140_T 161_Y 1.107 0.86
108_K 196_G 1.105 0.86
41_G 54_I 1.094 0.85
220_V 224_A 1.089 0.85
110_L 126_P 1.086 0.85
78_V 94_V 1.085 0.85
51_T 54_I 1.074 0.84
10_S 13_R 1.067 0.83
260_N 264_D 1.051 0.82
145_E 151_G 1.034 0.81
92_A 110_L 1.028 0.80
53_H 217_R 1.021 0.79
120_V 130_L 1.01 0.78
89_A 195_V 1.01 0.78
107_P 142_H 1.008 0.78
117_Q 123_A 1.007 0.78
171_Y 185_E 1.004 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4kixC10.99631000.035Contact Map0.653
3j3wC111000.035Contact Map0.595
3v2dD111000.041Contact Map0.706
3bboE10.97071000.065Contact Map0.284
3j21B10.81321000.31Contact Map0.635
1vq8A10.82051000.314Contact Map0.653
3j3bA10.87181000.329Contact Map0.598
4bynA10.84251000.331Contact Map0.645
3iz5B10.87181000.332Contact Map0.552
3zf7e10.87911000.334Contact Map0.628

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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