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OPENSEQ.org
RSMH - Ribosomal RNA small subunit methyltransferase H
UniProt: P60390 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11085
Length: 313 (302)
Sequences: 1952
Seq/Len: 6.46
RSMH
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
152_L 204_T 4.826 1.00
214_S 217_E 4.668 1.00
30_G 100_L 3.695 1.00
38_S 51_L 3.348 1.00
282_R 309_E 2.981 1.00
40_L 43_S 2.956 1.00
18_G 307_I 2.895 1.00
175_Q 182_E 2.783 1.00
96_D 231_A 2.715 1.00
100_L 222_A 2.64 1.00
139_W 211_W 2.62 1.00
143_A 211_W 2.555 1.00
54_I 77_G 2.53 1.00
139_W 143_A 2.494 1.00
34_R 107_P 2.487 1.00
77_G 81_A 2.425 1.00
177_M 186_V 2.4 1.00
80_S 218_E 2.36 1.00
50_R 73_S 2.338 1.00
58_P 130_P 2.293 1.00
281_L 308_A 2.207 1.00
54_I 85_Y 2.206 1.00
150_W 154_T 2.175 1.00
77_G 85_Y 2.079 1.00
78_P 218_E 2.078 1.00
235_R 309_E 2.061 1.00
14_E 290_G 2.047 1.00
171_R 182_E 2.047 1.00
56_R 218_E 2.021 1.00
12_L 40_L 1.956 1.00
28_I 95_I 1.933 1.00
56_R 78_P 1.921 1.00
104_V 109_L 1.894 1.00
147_D 150_W 1.878 1.00
153_K 161_A 1.863 1.00
83_G 225_S 1.85 1.00
227_L 281_L 1.841 1.00
253_M 283_A 1.821 1.00
61_I 74_I 1.796 1.00
118_F 202_T 1.779 1.00
121_D 181_K 1.767 1.00
145_E 166_R 1.767 1.00
106_S 110_D 1.758 1.00
106_S 299_R 1.747 1.00
149_A 162_K 1.686 1.00
94_K 231_A 1.659 1.00
83_G 228_N 1.655 1.00
140_L 177_M 1.631 1.00
253_M 308_A 1.623 1.00
144_E 147_D 1.568 0.99
149_A 153_K 1.566 0.99
80_S 221_Q 1.562 0.99
28_I 86_V 1.546 0.99
17_N 44_Q 1.541 0.99
145_E 149_A 1.526 0.99
145_E 162_K 1.524 0.99
102_L 219_I 1.519 0.99
7_H 10_V 1.503 0.99
237_S 305_L 1.493 0.99
237_S 307_I 1.491 0.99
167_A 190_A 1.468 0.99
139_W 208_V 1.439 0.99
145_E 169_V 1.434 0.99
75_I 89_R 1.418 0.99
150_W 153_K 1.408 0.99
58_P 76_H 1.404 0.99
230_L 236_L 1.404 0.99
37_H 239_I 1.403 0.99
11_L 287_L 1.398 0.98
87_A 229_V 1.393 0.98
52_L 91_L 1.393 0.98
187_V 204_T 1.392 0.98
157_E 244_L 1.385 0.98
16_V 40_L 1.375 0.98
292_E 296_E 1.373 0.98
153_K 162_K 1.372 0.98
219_I 249_V 1.366 0.98
233_G 309_E 1.362 0.98
26_I 52_L 1.355 0.98
8_T 296_E 1.326 0.98
75_I 85_Y 1.324 0.98
110_D 299_R 1.302 0.97
288_M 304_V 1.294 0.97
135_S 138_E 1.289 0.97
171_R 186_V 1.288 0.97
11_L 239_I 1.285 0.97
217_E 220_E 1.285 0.97
143_A 148_I 1.275 0.97
38_S 72_F 1.275 0.97
40_L 44_Q 1.264 0.97
41_I 49_G 1.24 0.96
95_I 98_I 1.236 0.96
170_E 173_R 1.232 0.96
22_R 96_D 1.228 0.96
171_R 177_M 1.219 0.96
37_H 99_L 1.218 0.96
45_L 49_G 1.217 0.96
76_H 131_T 1.212 0.95
27_Y 97_G 1.212 0.95
137_A 176_P 1.205 0.95
138_E 142_T 1.205 0.95
178_T 182_E 1.203 0.95
82_L 229_V 1.193 0.95
53_A 72_F 1.185 0.95
18_G 237_S 1.185 0.95
148_I 152_L 1.184 0.95
134_Q 143_A 1.166 0.94
98_I 229_V 1.164 0.94
169_V 172_N 1.155 0.94
76_H 129_D 1.15 0.93
185_E 188_A 1.146 0.93
157_E 247_R 1.145 0.93
62_A 66_T 1.143 0.93
260_P 269_T 1.142 0.93
188_A 199_H 1.138 0.93
167_A 170_E 1.136 0.93
186_V 190_A 1.134 0.93
121_D 179_R 1.133 0.93
58_P 62_A 1.131 0.93
163_R 190_A 1.124 0.92
134_Q 142_T 1.124 0.92
220_E 248_I 1.107 0.92
24_D 48_E 1.099 0.91
136_A 208_V 1.094 0.91
102_L 238_I 1.088 0.91
27_Y 41_I 1.088 0.91
181_K 185_E 1.087 0.91
163_R 192_P 1.079 0.90
112_A 120_R 1.078 0.90
9_T 15_A 1.075 0.90
39_R 43_S 1.074 0.90
13_D 17_N 1.069 0.90
232_P 311_T 1.069 0.90
226_S 236_L 1.068 0.90
32_F 39_R 1.067 0.90
184_A 187_V 1.067 0.90
149_A 161_A 1.062 0.89
61_I 76_H 1.058 0.89
21_I 45_L 1.053 0.89
137_A 178_T 1.05 0.89
160_F 191_T 1.049 0.88
85_Y 88_E 1.048 0.88
38_S 41_I 1.048 0.88
175_Q 178_T 1.045 0.88
149_A 165_A 1.045 0.88
59_Q 107_P 1.033 0.87
86_V 91_L 1.031 0.87
62_A 65_K 1.031 0.87
15_A 41_I 1.03 0.87
171_R 174_E 1.026 0.87
139_W 151_V 1.024 0.87
9_T 16_V 1.022 0.87
262_V 269_T 1.019 0.86
52_L 75_I 1.019 0.86
27_Y 49_G 1.017 0.86
145_E 165_A 1.016 0.86
129_D 132_R 1.012 0.86
41_I 51_L 1.01 0.86
21_I 41_I 1.009 0.86
216_L 244_L 1.009 0.86
15_A 237_S 1.007 0.86
216_L 248_I 1.005 0.85
141_Q 177_M 1.002 0.85
289_P 303_S 1 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tkaA111000.186Contact Map0.766
1wg8A20.90421000.236Contact Map0.822
1m6yA20.90731000.295Contact Map0.824
3eeyA100.597498.70.91Contact Map0.761
3mb5A10.565598.40.917Contact Map0.702
1o54A10.562398.30.92Contact Map0.715
3m4xA10.680598.20.921Contact Map0.688
2pwyA20.559198.20.921Contact Map0.612
3ajdA10.642298.20.922Contact Map0.769
1sqgA10.63998.20.922Contact Map0.622
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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