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OPENSEQ.org

YGGU - UPF0235 protein YggU
UniProt: P52060 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12981
Length: 96 (95)
Sequences: 550
Seq/Len: 5.79

YGGU
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
17_I 51_L 3.002 1.00
24_D 39_T 2.914 1.00
56_G 66_V 1.938 1.00
61_V 81_I 1.848 1.00
70_K 78_Q 1.846 1.00
33_E 76_H 1.808 1.00
20_K 46_Q 1.757 1.00
38_I 51_L 1.731 1.00
52_V 68_I 1.729 1.00
43_V 46_Q 1.696 1.00
19_P 75_R 1.672 1.00
7_N 10_G 1.626 0.99
55_L 79_I 1.605 0.99
39_T 50_H 1.604 0.99
55_L 66_V 1.556 0.99
16_Y 76_H 1.477 0.99
24_D 50_H 1.44 0.98
68_I 79_I 1.431 0.98
28_G 35_K 1.416 0.98
67_V 82_I 1.41 0.98
49_S 53_K 1.4 0.98
10_G 80_K 1.394 0.98
25_S 37_A 1.374 0.98
36_V 55_L 1.367 0.98
20_K 42_P 1.357 0.98
14_R 78_Q 1.323 0.97
90_E 95_I 1.305 0.97
54_F 58_Q 1.291 0.96
12_V 80_K 1.284 0.96
52_V 66_V 1.276 0.96
18_Q 43_V 1.246 0.95
53_K 63_K 1.224 0.95
36_V 51_L 1.203 0.94
18_Q 35_K 1.203 0.94
36_V 54_F 1.198 0.94
49_S 52_V 1.179 0.93
21_A 24_D 1.17 0.93
69_E 78_Q 1.157 0.92
41_P 44_D 1.154 0.92
26_I 36_V 1.154 0.92
89_P 93_A 1.136 0.91
89_P 92_A 1.113 0.90
27_V 37_A 1.109 0.90
48_N 51_L 1.078 0.88
90_E 94_L 1.065 0.87
15_L 36_V 1.02 0.84
38_I 54_F 1.011 0.84
18_Q 41_P 1.008 0.83
28_G 75_R 1.003 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1n91A111000.082Contact Map0.564
1jrmA10.947999.90.174Contact Map0.47
3nvzC2128.30.895Contact Map0.573
2w3sB4122.40.9Contact Map0.579
1t6aA10.770817.30.905Contact Map0.487
3zyvA40.989616.70.906Contact Map0.618
3uncA2116.10.907Contact Map0.583
1t3qB2115.80.907Contact Map0.547
1rm6A20.968814.70.909Contact Map0.504
1ffvB20.979211.70.912Contact Map0.526

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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