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OPENSEQ.org
YGGR - Uncharacterized protein YggR
UniProt: P52052 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12978
Length: 326 (325)
Sequences: 4644
Seq/Len: 14.29
YGGR
Paralog alert: 0.58 [within 20: 0.19] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
115_L 259_A 3.203 1.00
283_T 308_V 3.122 1.00
155_L 185_G 2.955 1.00
229_G 232_Q 2.9 1.00
90_S 151_H 2.886 1.00
112_L 140_M 2.817 1.00
153_L 189_A 2.802 1.00
124_L 223_A 2.746 1.00
126_T 225_L 2.729 1.00
319_H 323_E 2.704 1.00
118_S 258_R 2.656 1.00
113_P 143_Y 2.59 1.00
102_Q 105_Q 2.427 1.00
261_L 279_L 2.314 1.00
19_H 193_D 2.278 1.00
150_A 196_V 2.253 1.00
268_D 274_V 2.163 1.00
33_R 267_V 2.156 1.00
289_L 304_T 2.129 1.00
181_T 184_S 2.123 1.00
146_Q 166_Q 2.103 1.00
306_Q 315_Q 2.073 1.00
81_S 192_E 2.005 1.00
316_S 320_R 1.988 1.00
29_R 193_D 1.98 1.00
15_V 30_I 1.955 1.00
125_V 136_T 1.952 1.00
86_R 159_V 1.925 1.00
311_I 319_H 1.922 1.00
116_L 140_M 1.878 1.00
9_L 13_H 1.859 1.00
288_N 292_E 1.829 1.00
318_Q 322_G 1.825 1.00
10_S 15_V 1.822 1.00
282_N 287_G 1.805 1.00
6_I 18_L 1.795 1.00
99_H 105_Q 1.792 1.00
202_L 211_A 1.788 1.00
202_L 223_A 1.777 1.00
30_I 35_E 1.758 1.00
126_T 227_T 1.717 1.00
286_V 298_L 1.716 1.00
282_N 290_I 1.714 1.00
316_S 319_H 1.676 1.00
82_A 91_L 1.651 1.00
96_L 161_Y 1.65 1.00
304_T 308_V 1.638 1.00
186_L 210_L 1.637 1.00
104_E 113_P 1.636 1.00
78_L 93_L 1.635 1.00
137_L 222_L 1.635 1.00
129_T 194_P 1.633 1.00
289_L 294_K 1.628 1.00
48_L 91_L 1.618 1.00
8_A 12_K 1.549 1.00
19_H 29_R 1.547 1.00
155_L 189_A 1.515 1.00
40_D 43_D 1.508 1.00
304_T 307_Q 1.506 1.00
53_D 56_Q 1.505 1.00
90_S 171_Q 1.495 1.00
234_V 257_L 1.469 1.00
283_T 304_T 1.469 1.00
117_K 143_Y 1.457 1.00
78_L 95_L 1.451 1.00
123_I 220_L 1.441 1.00
165_S 169_L 1.433 1.00
103_L 139_A 1.426 1.00
45_E 49_R 1.423 1.00
274_V 325_R 1.417 1.00
312_T 315_Q 1.415 1.00
114_E 118_S 1.405 0.99
175_I 179_C 1.395 0.99
285_A 308_V 1.384 0.99
268_D 272_G 1.384 0.99
202_L 208_I 1.382 0.99
197_I 214_A 1.378 0.99
131_S 263_Q 1.37 0.99
286_V 301_V 1.366 0.99
149_D 167_R 1.36 0.99
50_E 54_D 1.354 0.99
213_T 239_D 1.338 0.99
60_L 89_I 1.322 0.99
56_Q 59_I 1.321 0.99
231_A 280_L 1.317 0.99
60_L 179_C 1.313 0.99
90_S 153_L 1.306 0.99
301_V 305_G 1.305 0.99
142_G 166_Q 1.303 0.99
320_R 325_R 1.291 0.99
145_N 152_I 1.29 0.99
126_T 262_S 1.289 0.99
19_H 34_M 1.282 0.99
123_I 259_A 1.281 0.99
217_T 236_R 1.264 0.99
104_E 110_T 1.258 0.99
129_T 219_H 1.254 0.99
227_T 233_A 1.246 0.98
10_S 18_L 1.24 0.98
137_L 198_L 1.235 0.98
80_G 93_L 1.232 0.98
276_L 320_R 1.225 0.98
13_H 35_E 1.222 0.98
141_V 198_L 1.217 0.98
294_K 297_Q 1.213 0.98
257_L 260_V 1.206 0.98
115_L 123_I 1.202 0.98
52_L 56_Q 1.199 0.98
72_L 75_N 1.199 0.98
48_L 89_I 1.187 0.98
101_P 105_Q 1.186 0.98
142_G 146_Q 1.181 0.98
238_V 253_L 1.168 0.97
123_I 222_L 1.159 0.97
260_V 280_L 1.158 0.97
41_T 45_E 1.155 0.97
205_S 209_R 1.146 0.97
10_S 28_W 1.136 0.97
187_R 204_D 1.132 0.97
144_L 196_V 1.13 0.97
264_K 313_F 1.129 0.97
59_I 63_N 1.123 0.97
114_E 281_I 1.12 0.96
45_E 48_L 1.105 0.96
322_G 325_R 1.103 0.96
120_N 258_R 1.102 0.96
306_Q 319_H 1.099 0.96
209_R 213_T 1.088 0.96
15_V 28_W 1.084 0.96
306_Q 312_T 1.079 0.95
185_G 189_A 1.078 0.95
285_A 307_Q 1.077 0.95
280_L 310_M 1.076 0.95
189_A 197_I 1.075 0.95
113_P 117_K 1.074 0.95
311_I 315_Q 1.071 0.95
172_Q 176_G 1.069 0.95
44_V 48_L 1.068 0.95
83_F 173_R 1.064 0.95
300_H 303_Q 1.063 0.95
201_E 226_H 1.06 0.95
108_A 277_F 1.057 0.95
284_P 287_G 1.057 0.95
208_I 242_P 1.055 0.95
65_Q 179_C 1.052 0.95
168_C 172_Q 1.047 0.94
104_E 143_Y 1.046 0.94
176_G 179_C 1.044 0.94
150_A 168_C 1.042 0.94
41_T 44_V 1.04 0.94
122_L 221_V 1.037 0.94
311_I 316_S 1.037 0.94
208_I 240_S 1.036 0.94
213_T 236_R 1.036 0.94
47_L 50_E 1.033 0.94
305_G 310_M 1.026 0.94
258_R 287_G 1.019 0.93
31_R 268_D 1.019 0.93
172_Q 175_I 1.019 0.93
182_F 199_L 1.015 0.93
11_V 78_L 1.009 0.93
314_Q 317_Y 1.007 0.93
51_W 54_D 1.003 0.93
268_D 325_R 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ewvA111000.226Contact Map0.646
3jvvA311000.232Contact Map0.725
tr|GY00.9541000.34Contact Map
1p9rA10.9541000.349Contact Map0.669
2oap120.96011000.461Contact Map0.475
2eyuA20.70861000.466Contact Map0.786
4ihqA30.96631000.505Contact Map0.517
2gzaA30.88341000.523Contact Map0.594
4bloA120.785399.90.711Contact Map0.175
2pt7A60.81999.80.732Contact Map0.678
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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