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OPENSEQ.org
YHHY - Uncharacterized N-acetyltransferase YhhY
UniProt: P46854 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12945
Length: 162 (159)
Sequences: 16129
Seq/Len: 101.44
YHHY
Paralog alert: 0.88 [within 20: 0.30] - ratio of genomes with paralogs
Cluster includes: ATDA PHNO RIMI RIMJ RIML YAFP YEDL YHHY YIAC YJAB YJGM YNCA YPEA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
7_R 13_D 2.821 1.00
7_R 57_C 2.741 1.00
97_S 133_K 2.714 1.00
118_L 131_Y 2.349 1.00
104_I 136_F 2.343 1.00
138_I 141_T 2.228 1.00
23_Q 87_D 2.167 1.00
102_E 105_E 2.157 1.00
139_E 159_A 2.141 1.00
128_I 132_K 2.099 1.00
97_S 134_Y 2.06 1.00
63_V 90_W 2.025 1.00
132_K 138_I 1.966 1.00
129_K 132_K 1.942 1.00
66_L 103_M 1.879 1.00
15_E 38_D 1.766 1.00
138_I 156_Y 1.761 1.00
104_I 116_I 1.749 1.00
100_M 134_Y 1.741 1.00
16_A 19_Q 1.658 1.00
105_E 109_N 1.643 1.00
120_V 128_I 1.629 1.00
55_V 62_V 1.626 1.00
23_Q 88_S 1.603 1.00
128_I 138_I 1.547 1.00
104_I 160_R 1.508 1.00
120_V 131_Y 1.495 1.00
16_A 62_V 1.494 1.00
101_R 134_Y 1.488 1.00
38_D 42_Q 1.487 1.00
125_A 129_K 1.48 1.00
54_L 102_E 1.473 1.00
56_A 95_V 1.461 1.00
68_I 107_C 1.459 1.00
68_I 103_M 1.444 1.00
141_T 154_D 1.434 1.00
5_V 57_C 1.416 1.00
97_S 101_R 1.406 0.99
58_I 63_V 1.405 0.99
80_A 113_V 1.401 0.99
115_R 159_A 1.392 0.99
122_V 154_D 1.387 0.99
66_L 99_L 1.384 0.99
141_T 156_Y 1.375 0.99
3_E 98_A 1.375 0.99
114_D 144_K 1.371 0.99
9_A 55_V 1.366 0.99
147_L 152_Y 1.359 0.99
87_D 90_W 1.342 0.99
90_W 93_R 1.339 0.99
127_A 131_Y 1.326 0.99
61_D 89_R 1.315 0.99
122_V 141_T 1.302 0.99
125_A 128_I 1.299 0.99
91_K 126_P 1.293 0.99
128_I 158_M 1.292 0.99
107_C 116_I 1.29 0.99
102_E 106_M 1.287 0.99
128_I 156_Y 1.281 0.99
106_M 111_L 1.279 0.99
106_M 109_N 1.258 0.99
16_A 61_D 1.257 0.99
86_V 96_A 1.255 0.99
57_C 60_G 1.247 0.99
82_F 100_M 1.234 0.98
9_A 17_I 1.222 0.98
61_D 87_D 1.217 0.98
54_L 106_M 1.213 0.98
37_S 40_M 1.192 0.98
64_G 86_V 1.188 0.98
11_T 46_A 1.18 0.98
86_V 95_V 1.137 0.97
56_A 99_L 1.136 0.97
11_T 42_Q 1.133 0.97
19_Q 87_D 1.125 0.97
100_M 136_F 1.12 0.96
138_I 158_M 1.116 0.96
18_R 22_A 1.11 0.96
122_V 156_Y 1.106 0.96
19_Q 23_Q 1.086 0.96
25_E 88_S 1.073 0.95
123_D 153_V 1.071 0.95
130_V 134_Y 1.059 0.95
65_H 85_C 1.055 0.95
98_A 102_E 1.054 0.95
61_D 90_W 1.048 0.94
58_I 93_R 1.033 0.94
84_I 131_Y 1.02 0.93
96_A 130_V 1.012 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3r9fA20.987799.90.158Contact Map0.753
3tthA120.987799.90.165Contact Map0.732
2j8mA20.987799.90.165Contact Map0.775
4mi4A30.987799.90.169Contact Map0.833
4mhdA30.987799.90.169Contact Map0.798
4k4lA30.987799.90.17Contact Map0.783
2fckA10.987799.90.172Contact Map0.714
3fbuA20.975399.90.179Contact Map0.806
1s7kA10.987799.90.18Contact Map0.744
3dr6A30.993899.90.181Contact Map0.86
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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