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OPENSEQ.org
YHGF - Protein YhgF
UniProt: P46837 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12932
Length: 773 (724)
Sequences: 1302
Seq/Len: 1.80
YHGF
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
152_V 158_A 4.351 1.00
78_S 88_A 4.248 1.00
534_Q 537_L 4.05 1.00
141_A 144_Q 3.981 1.00
345_V 447_A 3.878 1.00
154_D 157_A 3.825 1.00
229_G 235_L 3.806 1.00
331_G 447_A 3.803 1.00
73_I 100_L 3.394 1.00
85_D 88_A 3.353 1.00
147_Y 150_K 3.289 1.00
128_D 169_R 3.268 1.00
51_T 430_A 3.247 1.00
88_A 92_N 3.068 1.00
305_D 478_Q 2.982 1.00
354_T 440_L 2.945 1.00
361_T 364_A 2.854 1.00
532_N 560_D 2.849 1.00
13_E 59_R 2.813 1.00
678_V 719_M 2.752 1.00
683_L 688_V 2.686 1.00
653_I 704_K 2.642 1.00
561_N 577_E 2.641 1.00
218_V 226_M 2.624 1.00
461_D 464_S 2.593 1.00
531_Q 535_Q 2.498 1.00
582_A 605_F 2.486 1.00
141_A 145_Y 2.475 1.00
163_R 277_G 2.455 1.00
112_R 117_I 2.434 1.00
89_K 93_A 2.433 1.00
357_I 367_A 2.396 1.00
26_R 30_E 2.375 1.00
192_S 226_M 2.372 1.00
601_K 604_D 2.354 1.00
373_A 377_K 2.345 1.00
74_L 83_L 2.334 1.00
124_E 128_D 2.308 1.00
706_L 716_A 2.302 1.00
163_R 274_W 2.297 1.00
646_N 710_L 2.291 1.00
230_R 296_M 2.288 1.00
17_R 20_Q 2.273 1.00
137_T 140_V 2.249 1.00
281_W 285_I 2.236 1.00
353_A 377_K 2.228 1.00
114_R 164_Y 2.188 0.99
153_A 157_A 2.184 0.99
226_M 237_L 2.153 0.99
606_T 612_V 2.152 0.99
29_D 64_R 2.149 0.99
531_Q 560_D 2.108 0.99
427_E 431_Q 2.076 0.99
166_L 170_F 2.049 0.99
683_L 695_V 2.043 0.99
328_A 380_V 2.013 0.99
75_K 79_E 1.992 0.99
330_M 380_V 1.988 0.99
586_A 589_D 1.977 0.99
363_Q 366_K 1.973 0.99
368_A 404_Q 1.973 0.99
327_R 381_E 1.938 0.98
689_E 693_T 1.927 0.98
95_L 99_E 1.916 0.98
123_L 158_A 1.915 0.98
7_C 25_V 1.911 0.98
375_C 410_A 1.908 0.98
602_A 615_V 1.9 0.98
59_R 63_L 1.897 0.98
668_V 678_V 1.846 0.97
112_R 116_Q 1.84 0.97
213_E 222_R 1.839 0.97
140_V 143_A 1.833 0.97
112_R 120_E 1.818 0.97
24_A 53_L 1.815 0.97
77_I 82_K 1.81 0.97
371_V 398_Y 1.81 0.97
582_A 608_E 1.8 0.97
330_M 344_V 1.799 0.97
211_H 218_V 1.763 0.96
22_D 26_R 1.761 0.96
105_L 172_E 1.748 0.96
513_T 516_M 1.739 0.96
191_V 240_N 1.734 0.96
332_L 394_T 1.729 0.96
572_A 610_F 1.728 0.96
185_W 298_T 1.72 0.96
146_V 150_K 1.718 0.96
60_L 64_R 1.708 0.95
368_A 397_F 1.701 0.95
498_L 536_L 1.699 0.95
25_V 60_L 1.697 0.95
139_E 155_T 1.671 0.95
355_D 370_T 1.669 0.95
484_D 508_R 1.666 0.95
312_A 482_K 1.659 0.94
74_L 91_I 1.654 0.94
518_Q 522_A 1.648 0.94
129_L 141_A 1.637 0.94
706_L 718_T 1.632 0.94
556_I 559_G 1.612 0.93
430_A 433_F 1.612 0.93
81_G 85_D 1.599 0.93
707_E 716_A 1.597 0.93
351_L 433_F 1.594 0.93
78_S 81_G 1.593 0.93
350_K 525_D 1.593 0.93
126_L 158_A 1.592 0.93
99_E 178_A 1.585 0.92
70_R 100_L 1.577 0.92
259_M 276_K 1.577 0.92
313_R 692_H 1.567 0.92
351_L 436_L 1.559 0.92
545_K 548_E 1.558 0.92
674_Q 715_I 1.558 0.92
75_K 78_S 1.552 0.91
115_G 119_I 1.55 0.91
53_L 56_L 1.549 0.91
683_L 719_M 1.549 0.91
87_L 103_L 1.541 0.91
50_D 489_D 1.529 0.91
523_W 535_Q 1.526 0.90
190_L 226_M 1.525 0.90
281_W 286_K 1.523 0.90
690_D 693_T 1.521 0.90
28_L 57_E 1.518 0.90
198_K 201_E 1.516 0.90
332_L 340_V 1.503 0.90
156_K 160_D 1.5 0.89
160_D 164_Y 1.492 0.89
331_G 345_V 1.479 0.89
385_I 398_Y 1.477 0.88
655_E 702_K 1.476 0.88
328_A 347_A 1.474 0.88
653_I 702_K 1.473 0.88
402_Q 410_A 1.472 0.88
359_P 362_G 1.469 0.88
686_K 693_T 1.468 0.88
415_V 450_L 1.468 0.88
282_T 287_V 1.467 0.88
338_T 356_T 1.466 0.88
317_D 661_V 1.465 0.88
76_S 109_P 1.461 0.88
682_S 718_T 1.458 0.88
582_A 604_D 1.457 0.88
211_H 226_M 1.453 0.87
186_K 216_S 1.438 0.87
34_V 53_L 1.435 0.86
20_Q 48_L 1.434 0.86
193_T 210_D 1.431 0.86
602_A 619_I 1.426 0.86
579_I 615_V 1.424 0.86
300_R 304_E 1.421 0.86
28_L 34_V 1.409 0.85
650_P 707_E 1.398 0.85
6_F 67_E 1.395 0.84
354_T 439_S 1.386 0.84
572_A 575_V 1.385 0.84
402_Q 408_V 1.383 0.84
593_N 596_E 1.378 0.83
610_F 615_V 1.377 0.83
603_S 612_V 1.375 0.83
205_F 232_E 1.371 0.83
346_D 350_K 1.371 0.83
219_P 222_R 1.371 0.83
672_V 715_I 1.37 0.83
515_M 519_N 1.368 0.83
356_T 439_S 1.365 0.83
369_M 373_A 1.351 0.82
102_D 181_R 1.349 0.82
645_M 715_I 1.348 0.81
189_H 212_H 1.345 0.81
436_L 444_V 1.344 0.81
119_I 124_E 1.344 0.81
183_Y 187_N 1.34 0.81
342_V 394_T 1.34 0.81
329_T 345_V 1.333 0.80
124_E 169_R 1.33 0.80
158_A 162_A 1.328 0.80
684_S 688_V 1.325 0.80
527_N 538_K 1.32 0.80
576_V 583_T 1.316 0.79
90_A 99_E 1.312 0.79
682_S 723_E 1.312 0.79
143_A 155_T 1.304 0.78
376_E 408_V 1.302 0.78
336_L 360_H 1.297 0.78
399_L 412_K 1.296 0.78
330_M 342_V 1.296 0.78
585_Q 593_N 1.289 0.77
439_S 442_G 1.288 0.77
344_V 380_V 1.287 0.77
578_R 607_D 1.286 0.77
146_V 155_T 1.285 0.77
77_I 91_I 1.285 0.77
685_N 722_D 1.282 0.77
405_F 408_V 1.279 0.76
190_L 218_V 1.277 0.76
332_L 342_V 1.277 0.76
398_Y 402_Q 1.273 0.76
532_N 535_Q 1.273 0.76
38_A 53_L 1.271 0.76
353_A 378_H 1.268 0.76
136_H 141_A 1.267 0.76
121_A 157_A 1.264 0.75
612_V 616_T 1.264 0.75
316_H 320_M 1.261 0.75
704_K 721_L 1.256 0.75
123_L 152_V 1.255 0.75
30_E 44_I 1.252 0.74
218_V 223_A 1.25 0.74
159_L 274_W 1.243 0.74
351_L 354_T 1.241 0.73
688_V 693_T 1.238 0.73
77_I 80_Q 1.238 0.73
173_D 261_H 1.229 0.72
682_S 720_R 1.228 0.72
56_L 60_L 1.223 0.72
50_D 56_L 1.222 0.72
9_I 95_L 1.215 0.71
523_W 527_N 1.215 0.71
704_K 718_T 1.202 0.70
202_G 234_V 1.201 0.70
66_L 73_I 1.196 0.69
308_I 474_V 1.195 0.69
87_L 91_I 1.195 0.69
128_D 132_S 1.195 0.69
67_E 71_Q 1.193 0.69
391_S 414_I 1.189 0.69
184_L 291_L 1.189 0.69
7_C 22_D 1.188 0.69
195_V 233_G 1.188 0.69
526_E 538_K 1.187 0.69
306_E 309_N 1.182 0.68
688_V 694_V 1.182 0.68
184_L 288_L 1.178 0.68
152_V 162_A 1.178 0.68
522_A 526_E 1.177 0.68
131_W 169_R 1.176 0.68
351_L 444_V 1.171 0.67
57_E 61_S 1.17 0.67
164_Y 167_M 1.162 0.66
685_N 720_R 1.162 0.66
83_L 88_A 1.161 0.66
139_E 156_K 1.159 0.66
49_D 430_A 1.159 0.66
383_V 402_Q 1.151 0.65
74_L 88_A 1.15 0.65
167_M 285_I 1.149 0.65
180_V 287_V 1.146 0.65
365_A 369_M 1.145 0.65
577_E 581_A 1.141 0.64
478_Q 481_R 1.14 0.64
197_G 202_G 1.138 0.64
316_H 493_A 1.132 0.63
283_W 288_L 1.126 0.63
192_S 229_G 1.125 0.63
180_V 291_L 1.121 0.62
196_S 199_E 1.118 0.62
672_V 675_D 1.117 0.62
159_L 163_R 1.116 0.62
368_A 372_A 1.116 0.62
74_L 78_S 1.108 0.61
227_F 300_R 1.108 0.61
121_A 153_A 1.107 0.61
182_D 186_K 1.104 0.60
167_M 281_W 1.1 0.60
353_A 374_L 1.1 0.60
384_A 415_V 1.099 0.60
138_P 270_P 1.097 0.60
355_D 377_K 1.097 0.60
47_G 613_P 1.093 0.59
187_N 242_D 1.092 0.59
214_P 217_T 1.09 0.59
527_N 535_Q 1.089 0.59
68_E 71_Q 1.089 0.59
678_V 718_T 1.088 0.59
9_I 12_G 1.088 0.59
61_S 481_R 1.085 0.58
356_T 442_G 1.085 0.58
661_V 698_G 1.082 0.58
431_Q 518_Q 1.081 0.58
181_R 294_E 1.08 0.58
28_L 53_L 1.075 0.57
636_A 655_E 1.073 0.57
16_A 21_V 1.072 0.57
329_T 451_Q 1.069 0.57
129_L 136_H 1.066 0.56
547_F 551_A 1.065 0.56
574_P 577_E 1.063 0.56
10_I 21_V 1.06 0.56
644_T 673_H 1.055 0.55
638_F 657_A 1.054 0.55
275_R 278_V 1.054 0.55
433_F 444_V 1.053 0.55
597_L 619_I 1.053 0.55
298_T 302_R 1.052 0.55
534_Q 560_D 1.049 0.55
645_M 713_K 1.047 0.54
537_L 544_P 1.046 0.54
332_L 398_Y 1.042 0.54
179_K 257_I 1.041 0.54
192_S 235_L 1.041 0.54
29_D 60_L 1.04 0.54
223_A 296_M 1.04 0.54
357_I 360_H 1.039 0.53
130_L 271_A 1.039 0.53
50_D 53_L 1.037 0.53
568_V 621_E 1.037 0.53
70_R 94_T 1.035 0.53
91_I 103_L 1.034 0.53
53_L 430_A 1.033 0.53
69_R 101_E 1.031 0.53
575_V 619_I 1.031 0.53
709_D 712_R 1.029 0.52
347_A 529_Q 1.027 0.52
433_F 448_R 1.026 0.52
227_F 296_M 1.025 0.52
682_S 706_L 1.023 0.52
370_T 373_A 1.021 0.51
428_L 504_P 1.014 0.51
18_P 22_D 1.014 0.51
578_R 581_A 1.013 0.51
121_A 152_V 1.013 0.51
395_E 412_K 1.01 0.50
126_L 142_A 1.009 0.50
126_L 159_L 1.009 0.50
596_E 599_N 1.008 0.50
142_A 155_T 1.007 0.50
202_G 209_F 1.006 0.50
653_I 721_L 1.003 0.50
185_W 302_R 1.002 0.49
497_D 557_N 1.001 0.49
180_V 254_C 1 0.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bzcA10.98971000.174Contact Map0.688
3psiA10.98451000.251Contact Map0.441
3psfA10.97281000.257Contact Map0.48
2i5hA10.243299.80.926Contact Map0.352
3ci0K10.364899.70.932Contact Map0.268
1wi5A10.150199.70.933Contact Map0.381
2khjA10.14199.60.936Contact Map0.5
2k4kA10.156599.60.937Contact Map0.811
1luzA20.1199.60.938Contact Map0.532
3h0gG20.187699.50.939Contact Map0.449
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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