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OPENSEQ.org

YEDI - Inner membrane protein YedI
UniProt: P46125 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12709
Length: 305 (301)
Sequences: 496
Seq/Len: 1.65

YEDI
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
231_A 235_V 5.113 1.00
68_L 183_L 3.276 1.00
68_L 72_V 3.151 1.00
257_H 260_E 2.82 1.00
253_A 257_H 2.784 1.00
171_L 175_V 2.679 1.00
91_P 94_M 2.56 1.00
61_W 65_K 2.273 0.99
248_V 286_I 2.172 0.99
94_M 251_G 2.134 0.99
105_V 288_G 2.122 0.99
196_I 232_L 2.107 0.99
194_G 202_L 2.106 0.99
6_S 10_T 2.087 0.99
181_I 185_V 1.965 0.98
281_I 285_I 1.879 0.97
249_V 259_I 1.784 0.96
105_V 284_F 1.746 0.95
87_W 91_P 1.663 0.94
115_R 118_K 1.646 0.93
98_A 290_V 1.645 0.93
5_G 10_T 1.634 0.93
23_S 26_G 1.612 0.92
72_V 179_S 1.604 0.92
246_G 250_H 1.603 0.92
110_H 145_K 1.578 0.91
199_I 221_L 1.55 0.90
108_V 112_L 1.548 0.90
43_L 47_Q 1.501 0.88
166_V 177_V 1.493 0.88
112_L 235_V 1.482 0.87
65_K 69_I 1.436 0.85
290_V 294_V 1.435 0.85
202_L 217_L 1.428 0.84
94_M 98_A 1.427 0.84
277_V 281_I 1.423 0.84
41_L 192_L 1.419 0.84
257_H 261_H 1.413 0.83
18_L 22_I 1.399 0.83
54_N 57_L 1.397 0.83
127_R 130_K 1.387 0.82
109_L 291_V 1.383 0.82
7_S 10_T 1.382 0.82
261_H 264_G 1.376 0.81
249_V 282_L 1.375 0.81
242_L 282_L 1.361 0.80
172_L 176_L 1.36 0.80
262_F 265_Q 1.358 0.80
102_F 171_L 1.355 0.80
108_V 284_F 1.347 0.79
49_S 233_S 1.34 0.79
209_K 214_M 1.335 0.78
168_E 285_I 1.324 0.78
98_A 286_I 1.317 0.77
59_V 81_I 1.311 0.77
69_I 145_K 1.293 0.75
259_I 275_P 1.285 0.75
217_L 223_I 1.276 0.74
285_I 289_I 1.275 0.74
258_A 261_H 1.26 0.73
90_T 251_G 1.259 0.72
165_I 177_V 1.256 0.72
88_A 224_I 1.254 0.72
57_L 202_L 1.253 0.72
63_V 241_F 1.23 0.70
88_A 152_F 1.227 0.70
83_A 174_Q 1.218 0.69
289_I 299_K 1.217 0.69
49_S 148_I 1.214 0.68
62_G 141_K 1.206 0.68
246_G 279_N 1.204 0.68
38_G 166_V 1.195 0.67
51_V 143_K 1.166 0.64
108_V 234_I 1.165 0.64
72_V 183_L 1.162 0.64
223_I 227_W 1.161 0.63
60_V 64_A 1.16 0.63
259_I 278_L 1.157 0.63
64_A 68_L 1.153 0.63
92_L 229_M 1.153 0.63
53_A 293_G 1.142 0.62
195_V 202_L 1.138 0.61
82_S 174_Q 1.138 0.61
208_E 285_I 1.135 0.61
30_A 181_I 1.131 0.60
153_I 290_V 1.131 0.60
34_A 188_G 1.127 0.60
148_I 271_A 1.126 0.60
177_V 180_G 1.123 0.60
29_A 196_I 1.106 0.58
112_L 220_G 1.102 0.57
145_K 149_R 1.1 0.57
242_L 249_V 1.098 0.57
146_G 149_R 1.096 0.57
160_A 246_G 1.089 0.56
94_M 178_L 1.086 0.56
27_K 33_T 1.086 0.56
238_L 280_L 1.084 0.56
123_Q 126_Q 1.077 0.55
212_A 216_A 1.071 0.54
162_T 180_G 1.069 0.54
183_L 233_S 1.069 0.54
249_V 279_N 1.063 0.53
23_S 233_S 1.062 0.53
80_I 84_F 1.061 0.53
53_A 171_L 1.061 0.53
242_L 276_T 1.056 0.53
44_N 47_Q 1.056 0.53
148_I 207_A 1.055 0.53
138_K 142_D 1.055 0.53
240_M 244_G 1.052 0.52
12_L 221_L 1.052 0.52
43_L 63_V 1.046 0.52
89_I 235_V 1.044 0.51
148_I 215_Q 1.044 0.51
179_S 183_L 1.039 0.51
90_T 94_M 1.029 0.50
175_V 180_G 1.028 0.50
38_G 44_N 1.026 0.49
146_G 156_A 1.025 0.49
204_Y 222_L 1.021 0.49
95_I 290_V 1.019 0.49
249_V 300_M 1.018 0.49
41_L 45_A 1.018 0.49
219_K 223_I 1.017 0.49
47_Q 63_V 1.017 0.49
143_K 250_H 1.014 0.48
166_V 174_Q 1.014 0.48
109_L 113_E 1.011 0.48
79_L 175_V 1.009 0.48
25_M 199_I 1.005 0.47
211_S 215_Q 1.003 0.47
105_V 290_V 1.002 0.47
153_I 294_V 1 0.47
288_G 291_V 1 0.47
227_W 269_V 1 0.47
249_V 257_H 1 0.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
3arcX20.10496.10.982Contact Map0.728
3bz1X10.1414.90.983Contact Map0.519
2nq5A10.3413.90.984Contact Map0.797
4ainA30.35082.80.985Contact Map0.592
1mhmB10.21642.80.985Contact Map0
2kluA10.12132.70.985Contact Map0.626
1ypxA10.35082.40.985Contact Map0.363
3ze3A60.37052.10.986Contact Map0.275
1fryA10.091820.986Contact Map0.091
3j08A20.3181.90.986Contact Map0.158

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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