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OPENSEQ.org
DXR - 1-deoxy-D-xylulose 5-phosphate reductoisomerase
UniProt: P45568 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12715
Length: 398 (390)
Sequences: 1516
Seq/Len: 3.89
DXR
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_R 48_E 5.985 1.00
9_S 45_Q 4.138 1.00
17_T 98_M 3.407 1.00
19_D 277_R 3.397 1.00
204_D 349_Q 3.131 1.00
193_T 197_D 3.108 1.00
139_V 146_L 3.104 1.00
179_V 261_R 3.101 1.00
18_L 49_F 3.064 1.00
4_L 21_V 2.974 1.00
198_L 201_M 2.907 1.00
3_Q 29_R 2.86 1.00
223_A 353_F 2.754 1.00
192_E 314_R 2.71 1.00
180_S 247_E 2.64 1.00
352_R 355_D 2.595 1.00
355_D 358_A 2.591 1.00
298_D 301_K 2.535 1.00
243_A 325_F 2.509 1.00
344_A 348_A 2.458 1.00
22_R 49_F 2.376 1.00
119_T 145_Q 2.371 1.00
42_M 56_M 2.368 1.00
194_P 197_D 2.332 1.00
112_A 115_R 2.327 1.00
242_S 245_Q 2.319 1.00
180_S 261_R 2.311 1.00
111_L 138_A 2.307 1.00
115_R 138_A 2.305 1.00
226_M 335_L 2.279 1.00
38_N 41_R 2.233 1.00
253_Q 306_T 2.22 1.00
244_S 326_E 2.186 1.00
363_V 389_A 2.167 1.00
232_Y 322_M 2.086 1.00
21_V 30_V 1.967 1.00
343_V 347_L 1.967 1.00
43_V 68_M 1.951 1.00
374_C 377_D 1.947 1.00
331_A 364_L 1.882 1.00
191_R 308_A 1.865 1.00
192_E 308_A 1.849 1.00
363_V 385_A 1.848 1.00
361_L 365_E 1.832 1.00
259_M 299_F 1.829 1.00
229_G 321_A 1.816 1.00
33_L 45_Q 1.8 0.99
19_D 23_H 1.759 0.99
41_R 45_Q 1.752 0.99
30_V 33_L 1.743 0.99
137_D 141_Q 1.738 0.99
41_R 44_E 1.732 0.99
382_D 386_R 1.717 0.99
5_T 32_A 1.705 0.99
330_A 367_M 1.694 0.99
159_S 268_L 1.662 0.99
319_K 323_E 1.647 0.99
341_I 390_R 1.643 0.99
226_M 317_C 1.633 0.99
189_P 315_Y 1.601 0.98
193_T 201_M 1.595 0.98
207_C 220_V 1.588 0.98
207_C 219_S 1.584 0.98
295_K 301_K 1.569 0.98
39_V 56_M 1.566 0.98
10_T 35_A 1.564 0.98
317_C 357_A 1.554 0.98
46_C 54_A 1.554 0.98
114_I 120_I 1.549 0.98
54_A 76_T 1.541 0.98
55_V 88_M 1.538 0.98
196_R 199_A 1.525 0.98
15_C 41_R 1.523 0.98
138_A 141_Q 1.522 0.98
181_I 241_A 1.518 0.98
212_W 254_S 1.507 0.98
310_P 318_L 1.507 0.98
34_V 88_M 1.498 0.97
226_M 360_N 1.488 0.97
83_Q 87_D 1.483 0.97
27_H 288_N 1.477 0.97
44_E 48_E 1.472 0.97
127_S 135_F 1.458 0.97
236_R 325_F 1.457 0.97
179_V 296_P 1.453 0.97
29_R 52_R 1.447 0.97
15_C 45_Q 1.442 0.97
156_I 181_I 1.441 0.96
53_Y 79_L 1.436 0.96
193_T 205_Q 1.436 0.96
359_L 389_A 1.432 0.96
363_V 388_V 1.427 0.96
345_A 350_Q 1.427 0.96
345_A 393_V 1.426 0.96
312_Y 319_K 1.425 0.96
312_Y 322_M 1.415 0.96
198_L 354_T 1.414 0.96
236_R 246_M 1.413 0.96
34_V 85_A 1.396 0.96
31_V 91_L 1.386 0.95
110_T 120_I 1.374 0.95
387_E 391_K 1.367 0.95
203_P 347_L 1.359 0.95
258_S 270_Q 1.357 0.95
2_K 119_T 1.346 0.94
225_M 312_Y 1.344 0.94
301_K 309_A 1.343 0.94
61_S 64_L 1.328 0.94
111_L 135_F 1.328 0.94
341_I 389_A 1.322 0.94
388_V 391_K 1.322 0.94
247_E 309_A 1.321 0.94
114_I 144_A 1.317 0.93
115_R 142_S 1.309 0.93
202_T 205_Q 1.309 0.93
133_R 137_D 1.298 0.93
6_I 30_V 1.297 0.93
224_T 356_I 1.29 0.92
351_I 355_D 1.284 0.92
9_S 33_L 1.284 0.92
236_R 242_S 1.282 0.92
380_S 383_A 1.28 0.92
53_Y 88_M 1.278 0.92
130_T 378_V 1.275 0.92
62_A 66_K 1.269 0.92
236_R 243_A 1.268 0.92
217_K 339_N 1.266 0.92
154_N 282_H 1.264 0.91
37_K 58_D 1.261 0.91
56_M 62_A 1.253 0.91
324_A 364_L 1.249 0.91
366_K 388_V 1.247 0.91
190_F 206_A 1.246 0.91
232_Y 248_V 1.243 0.91
334_A 367_M 1.239 0.90
55_V 84_A 1.238 0.90
203_P 349_Q 1.238 0.90
323_E 365_E 1.236 0.90
232_Y 246_M 1.221 0.89
330_A 381_V 1.217 0.89
317_C 360_N 1.204 0.89
32_A 88_M 1.199 0.88
362_S 365_E 1.198 0.88
47_L 71_Q 1.182 0.87
383_A 387_E 1.182 0.87
373_Q 377_D 1.176 0.87
36_G 57_D 1.172 0.87
98_M 149_V 1.169 0.87
82_Q 108_L 1.168 0.87
189_P 192_E 1.16 0.86
225_M 314_R 1.157 0.86
385_A 389_A 1.155 0.86
39_V 65_L 1.143 0.85
367_M 384_N 1.139 0.85
40_T 64_L 1.124 0.84
182_L 247_E 1.124 0.84
52_R 93_D 1.116 0.83
195_L 314_R 1.111 0.83
56_M 61_S 1.103 0.82
52_R 77_E 1.102 0.82
133_R 237_W 1.096 0.81
46_C 51_P 1.094 0.81
9_S 41_R 1.087 0.81
232_Y 325_F 1.083 0.80
104_A 130_T 1.076 0.80
4_L 96_Q 1.074 0.80
53_Y 91_L 1.073 0.79
43_V 65_L 1.062 0.78
250_I 308_A 1.057 0.78
216_R 348_A 1.056 0.78
104_A 382_D 1.056 0.78
299_F 302_L 1.054 0.78
157_F 287_P 1.052 0.78
208_R 219_S 1.05 0.77
387_E 390_R 1.046 0.77
327_Q 331_A 1.046 0.77
46_C 69_L 1.046 0.77
108_L 379_L 1.042 0.77
40_T 44_E 1.042 0.77
99_A 127_S 1.035 0.76
156_I 258_S 1.03 0.75
149_V 283_T 1.025 0.75
316_P 361_L 1.022 0.75
220_V 347_L 1.02 0.74
5_T 88_M 1.013 0.74
40_T 68_M 1.012 0.74
341_I 345_A 1.012 0.74
211_N 272_G 1.009 0.73
380_S 384_N 1.007 0.73
203_P 219_S 1.006 0.73
96_Q 284_M 1.003 0.73
376_D 380_S 1.001 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1q0qA211000Contact Map0.802
3au8A20.9951000.006Contact Map0.8
3a06A20.92961000.034Contact Map0.712
2y1eA20.94221000.091Contact Map0.737
1r0kA40.96731000.124Contact Map0.825
3uplA20.89451000.841Contact Map0.483
3ingA10.698599.90.855Contact Map0.391
3do5A10.718699.90.859Contact Map0.552
2ejwA40.741299.70.896Contact Map0.482
3c8mA10.726199.50.909Contact Map0.548
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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