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OPENSEQ.org
PHP - Phosphotriesterase homology protein
UniProt: P45548 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12917
Length: 292 (290)
Sequences: 362
Seq/Len: 1.25
PHP
Paralog alert: 0.23 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
270_R 276_Q 2.902 1.00
43_L 48_V 2.881 1.00
148_H 177_V 2.4 0.99
169_L 204_A 2.289 0.99
157_T 168_Q 2.277 0.99
276_Q 280_D 2.155 0.98
120_A 153_R 2.063 0.98
170_A 202_L 1.99 0.97
236_N 281_V 1.985 0.97
123_I 144_A 1.941 0.96
142_I 175_H 1.933 0.96
68_D 72_E 1.917 0.96
197_L 232_R 1.893 0.96
280_D 284_R 1.89 0.96
275_S 278_D 1.872 0.95
67_L 71_R 1.814 0.94
107_D 111_Q 1.748 0.92
44_M 49_R 1.744 0.92
266_I 270_R 1.744 0.92
106_V 147_A 1.742 0.92
170_A 174_A 1.734 0.92
50_N 76_N 1.709 0.91
158_H 243_D 1.685 0.91
46_R 263_T 1.678 0.90
135_P 138_E 1.659 0.90
228_A 232_R 1.636 0.89
67_L 118_L 1.622 0.88
157_T 184_V 1.581 0.86
186_H 243_D 1.581 0.86
101_L 143_A 1.574 0.86
125_E 244_I 1.572 0.86
102_A 106_V 1.569 0.86
228_A 231_D 1.563 0.86
173_Q 202_L 1.544 0.85
173_Q 179_L 1.542 0.85
106_V 150_Q 1.538 0.84
148_H 155_I 1.538 0.84
211_I 265_F 1.532 0.84
53_E 153_R 1.527 0.84
109_I 153_R 1.511 0.83
179_L 182_V 1.489 0.82
128_T 157_T 1.475 0.81
266_I 283_L 1.471 0.81
237_R 280_D 1.469 0.80
106_V 151_T 1.468 0.80
15_L 77_V 1.46 0.80
142_I 146_L 1.436 0.78
138_E 142_I 1.431 0.78
33_Y 68_D 1.423 0.77
37_C 69_V 1.408 0.76
128_T 133_I 1.397 0.76
158_H 186_H 1.369 0.73
171_L 174_A 1.366 0.73
260_Y 265_F 1.361 0.73
39_E 257_G 1.353 0.72
192_N 195_N 1.344 0.72
37_C 73_T 1.341 0.71
133_I 167_E 1.339 0.71
6_T 50_N 1.338 0.71
126_I 144_A 1.326 0.70
93_V 101_L 1.305 0.68
48_V 262_L 1.292 0.67
227_H 231_D 1.285 0.67
186_H 209_D 1.283 0.66
235_L 281_V 1.268 0.65
239_M 275_S 1.259 0.64
157_T 172_L 1.24 0.62
78_V 121_G 1.236 0.62
37_C 72_E 1.234 0.62
146_L 175_H 1.23 0.62
13_E 212_G 1.216 0.60
198_K 201_D 1.205 0.59
189_L 210_T 1.202 0.59
123_I 126_I 1.201 0.59
156_S 185_G 1.195 0.58
235_L 278_D 1.189 0.58
120_A 155_I 1.187 0.57
234_L 238_V 1.177 0.57
213_K 216_Y 1.174 0.56
200_I 237_R 1.164 0.55
141_F 157_T 1.156 0.54
172_L 179_L 1.153 0.54
122_I 156_S 1.145 0.53
53_E 195_N 1.143 0.53
128_T 168_Q 1.134 0.52
185_G 222_R 1.13 0.52
96_R 100_E 1.123 0.51
169_L 184_V 1.119 0.51
145_A 172_L 1.116 0.51
235_L 274_F 1.115 0.50
93_V 139_K 1.115 0.50
15_L 187_C 1.114 0.50
41_N 73_T 1.111 0.50
54_M 80_C 1.11 0.50
280_D 285_E 1.109 0.50
10_L 13_E 1.108 0.50
48_V 261_L 1.101 0.49
84_Y 243_D 1.098 0.49
169_L 179_L 1.095 0.48
55_T 283_L 1.094 0.48
77_V 235_L 1.094 0.48
102_A 146_L 1.089 0.48
15_L 226_L 1.086 0.48
114_D 117_E 1.083 0.47
66_M 121_G 1.073 0.46
227_H 230_R 1.072 0.46
205_Y 286_N 1.065 0.46
125_E 186_H 1.061 0.45
10_L 242_M 1.056 0.45
78_V 259_D 1.054 0.44
55_T 145_A 1.054 0.44
53_E 145_A 1.049 0.44
254_G 257_G 1.048 0.44
211_I 214_N 1.043 0.43
13_E 241_S 1.042 0.43
185_G 283_L 1.042 0.43
15_L 66_M 1.042 0.43
45_T 224_A 1.041 0.43
157_T 206_V 1.037 0.43
56_N 240_L 1.036 0.43
125_E 243_D 1.035 0.43
56_N 125_E 1.031 0.42
84_Y 242_M 1.028 0.42
40_M 69_V 1.024 0.42
175_H 204_A 1.021 0.41
81_T 105_M 1.02 0.41
157_T 200_I 1.02 0.41
54_M 156_S 1.018 0.41
168_Q 184_V 1.018 0.41
66_M 79_A 1.017 0.41
69_V 76_N 1.014 0.41
195_N 204_A 1.013 0.41
99_Q 279_V 1.005 0.40
218_P 285_E 1.004 0.40
155_I 185_G 1.001 0.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3k2gA40.99661000.423Contact Map0.672
3rhgA10.99321000.439Contact Map0.628
3pnzA60.99661000.568Contact Map0.641
3ovgA60.99661000.583Contact Map0.661
1bf6A20.99661000.587Contact Map0.682
3gtxA10.99661000.593Contact Map0.64
3tn4A20.99661000.598Contact Map0.662
2vc7A40.99661000.606Contact Map0.655
4kezA40.99661000.607Contact Map0.671
2ob3A20.98291000.618Contact Map0.657
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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