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OPENSEQ.org
FADH - 2,4-dienoyl-CoA reductase [NADPH]
UniProt: P42593 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12723
Length: 672 (668)
Sequences: 1145
Seq/Len: 1.71
FADH
Paralog alert: 0.26 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
382_A 409_I 4.59 1.00
145_A 201_A 4.287 1.00
187_D 190_N 3.987 1.00
405_A 448_T 3.978 1.00
328_R 331_E 3.822 1.00
500_I 511_A 3.411 1.00
401_T 444_K 3.325 1.00
134_H 183_Q 3.302 1.00
91_V 98_I 2.988 1.00
436_I 443_L 2.892 1.00
331_E 438_V 2.789 1.00
99_A 158_G 2.678 1.00
663_A 667_R 2.662 1.00
497_K 557_Q 2.637 1.00
46_E 319_E 2.625 1.00
270_S 299_I 2.624 1.00
168_L 194_F 2.624 1.00
298_D 302_R 2.59 1.00
134_H 137_I 2.556 1.00
378_A 403_F 2.544 1.00
322_S 326_S 2.543 1.00
21_V 321_L 2.499 1.00
435_M 438_V 2.495 1.00
7_F 325_Q 2.484 1.00
450_T 453_Q 2.453 1.00
22_L 307_M 2.429 1.00
115_V 132_L 2.42 1.00
78_A 150_L 2.413 1.00
149_Q 205_R 2.397 1.00
274_R 304_D 2.397 1.00
10_L 307_M 2.354 1.00
190_N 193_R 2.344 1.00
238_I 243_A 2.337 1.00
646_L 650_C 2.302 1.00
376_N 399_Q 2.289 1.00
235_A 280_V 2.275 1.00
389_F 461_I 2.255 0.99
132_L 136_E 2.251 0.99
169_I 194_F 2.25 0.99
331_E 435_M 2.23 0.99
447_H 453_Q 2.19 0.99
297_D 300_L 2.189 0.99
436_I 441_V 2.169 0.99
5_S 301_S 2.149 0.99
330_D 434_R 2.123 0.99
45_A 94_E 2.123 0.99
584_L 589_V 2.106 0.99
132_L 140_L 2.093 0.99
169_I 198_V 2.065 0.99
163_G 214_Y 2.059 0.99
119_A 131_E 2.004 0.99
388_A 391_I 1.989 0.98
161_V 202_V 1.961 0.98
292_D 320_L 1.956 0.98
192_M 237_A 1.955 0.98
368_I 392_N 1.95 0.98
5_S 8_A 1.933 0.98
49_R 94_E 1.916 0.98
63_D 143_N 1.904 0.98
152_R 209_D 1.874 0.97
391_I 439_T 1.866 0.97
382_A 402_L 1.84 0.97
17_L 53_A 1.839 0.97
102_I 147_C 1.815 0.97
654_M 664_Q 1.814 0.97
403_F 444_K 1.812 0.97
378_A 457_F 1.802 0.97
395_A 435_M 1.787 0.96
557_Q 590_K 1.783 0.96
487_V 494_V 1.741 0.96
444_K 447_H 1.74 0.96
401_T 442_T 1.73 0.95
184_W 197_E 1.728 0.95
45_A 93_Q 1.723 0.95
122_A 125_N 1.721 0.95
236_Q 279_H 1.719 0.95
391_I 395_A 1.717 0.95
482_L 487_V 1.682 0.94
261_A 579_I 1.682 0.94
38_E 86_T 1.681 0.94
474_D 599_K 1.677 0.94
434_R 438_V 1.668 0.94
598_Q 608_V 1.664 0.94
403_F 449_V 1.66 0.94
213_I 245_I 1.658 0.94
169_I 195_A 1.647 0.94
299_I 305_A 1.647 0.94
402_L 409_I 1.645 0.94
15_T 97_K 1.637 0.93
173_L 195_A 1.633 0.93
392_N 666_T 1.619 0.93
92_H 157_D 1.616 0.93
274_R 278_G 1.588 0.92
451_A 636_P 1.588 0.92
417_K 426_Y 1.584 0.92
138_L 183_Q 1.581 0.92
399_Q 442_T 1.574 0.91
375_K 459_E 1.573 0.91
81_I 150_L 1.571 0.91
603_D 617_A 1.568 0.91
382_A 387_L 1.568 0.91
84_H 156_Y 1.568 0.91
145_A 205_R 1.563 0.91
239_E 281_S 1.558 0.91
173_L 192_M 1.549 0.91
665_G 669_A 1.546 0.90
434_R 437_E 1.536 0.90
134_H 184_W 1.528 0.90
559_V 592_I 1.528 0.90
214_Y 238_I 1.526 0.90
449_V 453_Q 1.525 0.90
377_L 668_L 1.523 0.90
130_H 136_E 1.517 0.89
138_L 184_W 1.515 0.89
459_E 645_H 1.512 0.89
601_D 606_H 1.512 0.89
380_V 462_L 1.512 0.89
496_N 557_Q 1.499 0.89
596_S 608_V 1.497 0.88
378_A 454_L 1.496 0.88
331_E 434_R 1.491 0.88
22_L 285_V 1.487 0.88
246_I 282_L 1.487 0.88
310_M 313_P 1.485 0.88
645_H 668_L 1.484 0.88
404_D 449_V 1.478 0.88
322_S 325_Q 1.475 0.87
99_A 213_I 1.472 0.87
238_I 246_I 1.472 0.87
138_L 201_A 1.47 0.87
203_R 212_I 1.462 0.87
326_S 331_E 1.46 0.87
4_P 297_D 1.459 0.87
15_T 211_I 1.457 0.87
407_S 446_N 1.456 0.87
85_R 89_E 1.453 0.86
146_R 150_L 1.452 0.86
196_V 237_A 1.45 0.86
201_A 204_E 1.448 0.86
41_A 87_I 1.448 0.86
371_A 374_K 1.445 0.86
195_A 214_Y 1.443 0.86
478_H 602_D 1.439 0.86
495_G 619_D 1.434 0.85
18_K 96_G 1.431 0.85
368_I 666_T 1.43 0.85
476_I 623_I 1.429 0.85
374_K 399_Q 1.428 0.85
201_A 205_R 1.428 0.85
141_I 184_W 1.423 0.85
232_V 279_H 1.422 0.85
132_L 137_I 1.412 0.84
52_V 314_F 1.394 0.83
590_K 614_Q 1.392 0.83
486_D 491_K 1.39 0.83
267_G 299_I 1.387 0.83
3_Y 329_A 1.387 0.83
162_M 165_E 1.376 0.82
149_Q 153_E 1.369 0.82
314_F 321_L 1.367 0.81
592_I 595_V 1.367 0.81
515_S 558_I 1.365 0.81
634_A 638_I 1.362 0.81
142_D 201_A 1.359 0.81
152_R 207_G 1.351 0.80
471_P 476_I 1.347 0.80
409_I 443_L 1.343 0.80
237_A 240_A 1.339 0.80
286_T 305_A 1.325 0.79
14_F 244_T 1.321 0.78
11_D 16_T 1.321 0.78
239_E 282_L 1.321 0.78
414_N 417_K 1.319 0.78
651_D 664_Q 1.318 0.78
7_F 324_A 1.318 0.78
529_C 536_S 1.317 0.78
23_M 47_R 1.312 0.78
482_L 620_N 1.307 0.77
44_Y 55_I 1.306 0.77
200_R 204_E 1.304 0.77
482_L 492_A 1.295 0.76
473_I 600_I 1.295 0.76
520_S 523_Q 1.294 0.76
275_K 278_G 1.288 0.76
499_A 618_V 1.277 0.75
294_Q 329_A 1.275 0.75
7_F 321_L 1.272 0.75
435_M 439_T 1.268 0.74
634_A 646_L 1.266 0.74
145_A 202_V 1.265 0.74
60_I 100_L 1.263 0.74
11_D 14_F 1.258 0.73
601_D 604_G 1.253 0.73
176_R 222_V 1.24 0.72
270_S 304_D 1.24 0.72
529_C 534_I 1.237 0.72
409_I 433_R 1.236 0.72
165_E 249_G 1.234 0.71
319_E 322_S 1.231 0.71
107_R 171_E 1.23 0.71
133_S 136_E 1.229 0.71
595_V 607_V 1.229 0.71
387_L 409_I 1.227 0.71
432_Y 436_I 1.227 0.71
22_L 56_V 1.226 0.71
131_E 181_S 1.226 0.71
116_A 119_A 1.225 0.71
598_Q 613_T 1.224 0.70
576_T 579_I 1.222 0.70
56_V 99_A 1.217 0.70
290_I 296_A 1.217 0.70
647_I 668_L 1.208 0.69
387_L 402_L 1.208 0.69
188_Y 192_M 1.206 0.69
211_I 245_I 1.204 0.69
497_K 617_A 1.202 0.68
46_E 359_R 1.2 0.68
7_F 21_V 1.19 0.67
24_G 309_S 1.188 0.67
462_L 634_A 1.186 0.67
501_I 625_A 1.185 0.67
14_F 211_I 1.182 0.67
378_A 449_V 1.178 0.66
228_F 275_K 1.178 0.66
88_T 156_Y 1.177 0.66
382_A 443_L 1.177 0.66
277_K 306_D 1.175 0.66
529_C 538_L 1.166 0.65
89_E 93_Q 1.165 0.65
138_L 197_E 1.162 0.65
5_S 297_D 1.16 0.64
524_N 527_G 1.159 0.64
393_A 665_G 1.154 0.64
387_L 443_L 1.147 0.63
12_L 211_I 1.142 0.63
176_R 224_D 1.139 0.62
488_L 513_Y 1.139 0.62
36_G 83_H 1.135 0.62
499_A 561_L 1.134 0.62
152_R 206_V 1.134 0.62
70_E 121_Q 1.133 0.62
310_M 320_L 1.131 0.62
101_Q 160_E 1.128 0.61
375_K 398_H 1.126 0.61
75_L 147_C 1.118 0.60
569_G 572_L 1.117 0.60
52_V 321_L 1.116 0.60
239_E 280_V 1.116 0.60
328_R 434_R 1.115 0.60
270_S 286_T 1.114 0.60
196_V 200_R 1.114 0.60
377_L 389_F 1.111 0.59
395_A 439_T 1.108 0.59
459_E 643_T 1.102 0.59
187_D 376_N 1.099 0.58
146_R 205_R 1.098 0.58
599_K 606_H 1.095 0.58
134_H 138_L 1.095 0.58
391_I 435_M 1.095 0.58
78_A 147_C 1.093 0.58
526_A 536_S 1.086 0.57
196_V 243_A 1.078 0.56
98_I 156_Y 1.074 0.56
522_S 525_I 1.074 0.56
152_R 210_F 1.073 0.56
387_L 436_I 1.071 0.55
454_L 457_F 1.066 0.55
290_I 299_I 1.065 0.55
377_L 393_A 1.065 0.55
518_G 555_P 1.064 0.55
78_A 81_I 1.062 0.54
275_K 279_H 1.062 0.54
382_A 404_D 1.061 0.54
299_I 304_D 1.058 0.54
74_M 80_Q 1.056 0.54
535_D 538_L 1.055 0.54
403_F 453_Q 1.053 0.53
140_L 168_L 1.052 0.53
233_E 237_A 1.051 0.53
408_E 433_R 1.051 0.53
24_G 311_A 1.048 0.53
206_V 210_F 1.047 0.53
289_R 337_G 1.045 0.53
158_G 211_I 1.043 0.52
454_L 462_L 1.042 0.52
388_A 392_N 1.041 0.52
42_A 364_T 1.038 0.52
218_M 248_T 1.036 0.52
522_S 528_F 1.035 0.51
528_F 536_S 1.033 0.51
235_A 246_I 1.031 0.51
537_S 545_S 1.03 0.51
618_V 621_V 1.03 0.51
484_Y 506_I 1.029 0.51
526_A 529_C 1.029 0.51
635_Q 638_I 1.028 0.51
320_L 324_A 1.024 0.50
665_G 668_L 1.023 0.50
669_A 672_I 1.02 0.50
203_R 206_V 1.02 0.50
355_L 658_A 1.02 0.50
42_A 45_A 1.016 0.49
647_I 665_G 1.016 0.49
216_L 248_T 1.015 0.49
202_V 212_I 1.015 0.49
368_I 371_A 1.015 0.49
536_S 545_S 1.014 0.49
631_R 635_Q 1.012 0.49
245_I 285_V 1.012 0.49
12_L 15_T 1.01 0.49
467_V 630_N 1.007 0.48
163_G 195_A 1.006 0.48
496_N 556_R 1.006 0.48
528_F 535_D 1.006 0.48
50_H 322_S 1.005 0.48
68_G 105_T 1.005 0.48
199_V 241_A 1.003 0.48
63_D 139_Q 1.003 0.48
345_Q 659_R 1.002 0.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ps9A10.99851000.353Contact Map0.781
3k30A20.93011000.373Contact Map0.76
1o94A20.93151000.384Contact Map0.747
3l5aA10.55061000.615Contact Map0.744
2hsaB20.53271000.615Contact Map0.763
3tjlA10.54461000.626Contact Map0.668
3l5lA10.50741000.629Contact Map0.731
4e2bA10.50451000.631Contact Map0.716
4gbuA10.53271000.633Contact Map0.692
4jicA30.51641000.637Contact Map0.681
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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