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MLTB - Membrane-bound lytic murein transglycosylase B
UniProt: P41052 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12699
Length: 361 (307)
Sequences: 981
Seq/Len: 3.20
MLTB
Paralog alert: 0.29 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
271_V 305_P 4.536 1.00
266_V 269_D 3.314 1.00
195_E 229_S 3.278 1.00
145_W 152_P 3.062 1.00
63_F 67_M 2.841 1.00
144_A 254_G 2.698 1.00
221_M 247_W 2.516 1.00
143_R 147_V 2.488 1.00
89_D 93_R 2.44 1.00
144_A 253_I 2.309 1.00
124_P 128_Q 2.296 1.00
258_N 261_K 2.191 1.00
272_A 305_P 2.115 1.00
138_E 142_N 2.01 1.00
88_L 176_D 1.984 1.00
82_L 85_A 1.947 1.00
87_R 92_L 1.925 1.00
75_R 79_Q 1.906 0.99
314_L 327_Y 1.898 0.99
239_S 248_D 1.883 0.99
235_A 244_I 1.88 0.99
157_G 352_G 1.851 0.99
141_L 156_V 1.848 0.99
78_L 82_L 1.806 0.99
69_N 271_V 1.785 0.99
269_D 329_L 1.756 0.99
82_L 196_L 1.749 0.99
198_T 232_K 1.715 0.99
209_D 212_N 1.708 0.99
148_Y 236_V 1.688 0.98
174_I 215_G 1.673 0.98
198_T 229_S 1.647 0.98
134_W 156_V 1.645 0.98
191_Y 227_M 1.642 0.98
172_T 177_A 1.603 0.98
140_A 144_A 1.595 0.98
158_I 338_Y 1.586 0.97
237_D 241_D 1.574 0.97
142_N 145_W 1.572 0.97
173_R 176_D 1.564 0.97
238_F 254_G 1.55 0.97
175_L 196_L 1.54 0.97
73_F 204_R 1.532 0.97
155_I 253_I 1.531 0.97
174_I 221_M 1.523 0.97
94_L 172_T 1.521 0.97
192_F 227_M 1.509 0.96
224_G 256_V 1.479 0.96
245_N 248_D 1.468 0.96
63_F 183_F 1.456 0.95
95_M 187_R 1.447 0.95
266_V 330_P 1.446 0.95
54_F 184_N 1.433 0.95
82_L 175_L 1.428 0.95
338_Y 344_Y 1.423 0.94
77_Q 204_R 1.412 0.94
158_I 344_Y 1.407 0.94
90_S 94_L 1.398 0.94
133_F 136_Q 1.387 0.93
349_W 353_Q 1.383 0.93
139_D 142_N 1.38 0.93
64_I 68_V 1.376 0.93
73_F 197_E 1.374 0.93
199_F 213_L 1.373 0.93
163_T 256_V 1.362 0.93
154_I 352_G 1.362 0.93
153_E 356_A 1.356 0.92
290_Y 294_Q 1.321 0.91
161_V 347_A 1.32 0.91
127_V 354_A 1.314 0.91
195_E 198_T 1.314 0.91
87_R 184_N 1.312 0.91
157_G 355_V 1.311 0.91
88_L 91_V 1.308 0.90
159_I 256_V 1.295 0.90
74_D 204_R 1.287 0.90
124_P 354_A 1.278 0.89
151_P 356_A 1.256 0.88
90_S 93_R 1.243 0.87
203_A 210_P 1.24 0.87
294_Q 297_A 1.231 0.87
231_Y 244_I 1.228 0.86
61_Q 64_I 1.224 0.86
350_Q 354_A 1.224 0.86
318_D 323_Y 1.22 0.86
85_A 176_D 1.217 0.86
336_T 340_H 1.215 0.86
137_Y 140_A 1.204 0.85
67_M 73_F 1.199 0.85
114_W 338_Y 1.193 0.84
66_K 193_S 1.192 0.84
269_D 310_Q 1.188 0.84
336_T 342_T 1.185 0.84
173_R 210_P 1.183 0.83
294_Q 298_A 1.181 0.83
254_G 257_A 1.179 0.83
79_Q 83_S 1.174 0.83
237_D 242_G 1.171 0.83
261_K 267_K 1.156 0.81
319_V 322_G 1.156 0.81
289_K 333_Y 1.152 0.81
134_W 138_E 1.148 0.81
234_Y 263_H 1.146 0.81
200_L 210_P 1.144 0.81
207_Q 244_I 1.139 0.80
348_V 351_L 1.136 0.80
270_Q 329_L 1.13 0.79
71_H 197_E 1.13 0.79
135_N 139_D 1.128 0.79
129_N 133_F 1.122 0.79
224_G 252_A 1.121 0.79
177_A 322_G 1.121 0.79
155_I 256_V 1.119 0.78
226_F 255_S 1.118 0.78
136_Q 146_Q 1.116 0.78
114_W 158_I 1.112 0.78
73_F 81_I 1.111 0.78
201_L 204_R 1.101 0.77
170_G 255_S 1.097 0.77
134_W 355_V 1.091 0.76
68_V 79_Q 1.077 0.75
205_D 232_K 1.073 0.74
195_E 227_M 1.068 0.74
68_V 98_Q 1.062 0.73
234_Y 262_A 1.062 0.73
85_A 196_L 1.061 0.73
195_E 233_Q 1.053 0.72
130_G 165_W 1.051 0.72
199_F 202_M 1.05 0.72
252_A 256_V 1.049 0.72
88_L 177_A 1.049 0.72
129_N 167_R 1.049 0.72
71_H 201_L 1.045 0.71
129_N 132_V 1.044 0.71
333_Y 336_T 1.042 0.71
169_M 223_Y 1.04 0.71
296_A 308_N 1.04 0.71
78_L 200_L 1.034 0.70
95_M 185_Y 1.032 0.70
191_Y 230_S 1.032 0.70
350_Q 353_Q 1.023 0.69
64_I 82_L 1.021 0.69
67_M 196_L 1.016 0.68
230_S 259_Y 1.014 0.68
95_M 98_Q 1.011 0.68
164_R 168_V 1.009 0.68
133_F 137_Y 1.007 0.67
195_E 256_V 1.005 0.67
221_M 246_L 1.004 0.67
127_V 351_L 1.004 0.67
54_F 57_N 1.004 0.67
315_L 328_G 1.003 0.67
290_Y 298_A 1.002 0.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1qusA10.8921000.244Contact Map0.701
4anrA10.87811000.255Contact Map0.692
3gxrA40.493199.50.872Contact Map0.643
4g9sA10.437799.50.874Contact Map0.588
1qsaA10.736899.20.895Contact Map0.481
1gbsA10.487599.20.896Contact Map0.564
3t21A20.498699.10.899Contact Map0.514
3w6bA40.484898.10.926Contact Map0.546
3bkhA10.664897.90.931Contact Map0.501
4g54A10.335295.10.95Contact Map0.349
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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