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OPENSEQ.org
YFEH - Uncharacterized protein YfeH
UniProt: P39836 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12376
Length: 332 (315)
Sequences: 2580
Seq/Len: 8.19
YFEH
Paralog alert: 0.42 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
125_N 260_D 5.237 1.00
47_F 181_S 4.99 1.00
249_F 253_R 3.285 1.00
119_T 124_G 2.739 1.00
75_T 110_A 2.519 1.00
276_G 296_L 2.508 1.00
47_F 177_L 2.385 1.00
251_A 264_I 2.29 1.00
104_Y 280_A 2.107 1.00
258_K 262_I 2.068 1.00
245_V 249_F 2.066 1.00
85_L 89_W 2.033 1.00
73_C 77_V 2.016 1.00
252_R 261_E 2.001 1.00
251_A 261_E 1.984 1.00
79_F 243_V 1.973 1.00
60_A 63_G 1.943 1.00
107_I 147_L 1.918 1.00
59_I 63_G 1.891 1.00
129_A 263_T 1.886 1.00
12_L 16_T 1.857 1.00
257_N 260_D 1.853 1.00
159_G 162_E 1.835 1.00
110_A 133_A 1.821 1.00
179_H 183_P 1.787 1.00
119_T 129_A 1.782 1.00
57_A 60_A 1.767 1.00
268_G 271_K 1.742 1.00
70_W 264_I 1.657 1.00
15_I 19_L 1.652 1.00
256_F 264_I 1.636 1.00
248_V 261_E 1.636 1.00
169_L 173_L 1.632 1.00
82_L 243_V 1.597 1.00
17_V 205_L 1.591 1.00
74_S 250_M 1.547 1.00
69_L 73_C 1.544 1.00
242_I 246_V 1.543 1.00
139_L 143_L 1.514 1.00
118_F 266_F 1.511 1.00
143_L 146_L 1.505 1.00
76_F 143_L 1.498 1.00
270_K 273_L 1.493 1.00
72_M 139_L 1.492 1.00
56_E 59_I 1.482 0.99
119_T 263_T 1.477 0.99
13_T 205_L 1.466 0.99
75_T 133_A 1.464 0.99
30_F 33_F 1.453 0.99
180_L 184_W 1.44 0.99
250_M 254_L 1.435 0.99
108_L 276_G 1.403 0.99
176_V 180_L 1.388 0.99
19_L 22_S 1.388 0.99
168_M 173_L 1.388 0.99
83_G 106_C 1.377 0.99
26_A 29_D 1.373 0.99
161_L 165_G 1.363 0.99
237_C 302_I 1.361 0.99
74_S 247_N 1.36 0.99
81_I 85_L 1.352 0.99
110_A 115_A 1.344 0.99
310_L 314_Y 1.338 0.99
240_L 306_V 1.332 0.99
111_T 114_S 1.331 0.99
44_L 199_T 1.324 0.99
66_R 256_F 1.315 0.99
302_I 306_V 1.304 0.98
269_S 272_S 1.297 0.98
191_R 195_W 1.288 0.98
86_F 102_F 1.28 0.98
189_V 193_K 1.278 0.98
70_W 254_L 1.273 0.98
162_E 165_G 1.257 0.98
16_T 19_L 1.254 0.98
20_L 24_F 1.246 0.98
21_A 28_G 1.23 0.97
107_I 148_V 1.23 0.97
248_V 258_K 1.222 0.97
29_D 32_P 1.221 0.97
98_L 232_I 1.219 0.97
65_W 69_L 1.212 0.97
82_L 242_I 1.199 0.97
110_A 132_S 1.195 0.97
314_Y 317_Q 1.195 0.97
300_H 304_L 1.192 0.97
87_A 99_Y 1.191 0.97
54_S 57_A 1.189 0.97
309_V 313_R 1.188 0.97
84_V 88_W 1.182 0.97
138_L 142_F 1.179 0.96
265_V 314_Y 1.177 0.96
76_F 136_S 1.176 0.96
25_P 28_G 1.173 0.96
230_L 234_V 1.169 0.96
102_F 235_V 1.168 0.96
143_L 147_L 1.165 0.96
268_G 272_S 1.156 0.96
85_L 88_W 1.155 0.96
100_S 148_V 1.149 0.96
125_N 259_A 1.147 0.96
42_I 46_F 1.144 0.96
180_L 183_P 1.136 0.95
225_G 228_S 1.132 0.95
97_M 291_M 1.13 0.95
147_L 151_V 1.12 0.95
36_N 40_A 1.115 0.95
56_E 60_A 1.112 0.95
78_L 82_L 1.108 0.94
269_S 273_L 1.106 0.94
127_A 130_V 1.096 0.94
299_F 304_L 1.092 0.94
204_I 215_A 1.092 0.94
182_R 190_S 1.087 0.94
26_A 30_F 1.085 0.94
103_L 108_L 1.083 0.94
251_A 256_F 1.08 0.93
64_H 125_N 1.08 0.93
158_G 163_Q 1.078 0.93
122_A 311_A 1.072 0.93
64_H 260_D 1.071 0.93
19_L 23_F 1.057 0.92
261_E 314_Y 1.054 0.92
8_D 12_L 1.053 0.92
291_M 295_P 1.051 0.92
261_E 265_V 1.048 0.92
188_W 192_N 1.045 0.92
240_L 270_K 1.043 0.92
262_I 314_Y 1.039 0.92
105_L 299_F 1.034 0.91
73_C 78_L 1.033 0.91
81_I 151_V 1.028 0.91
313_R 317_Q 1.027 0.91
115_A 133_A 1.025 0.91
11_T 15_I 1.019 0.91
40_A 43_A 1.017 0.90
241_A 245_V 1.014 0.90
202_T 217_V 1.012 0.90
120_S 123_G 1.011 0.90
307_C 311_A 1.008 0.90
67_L 260_D 1.007 0.90
106_C 243_V 1.006 0.90
16_T 20_L 1.005 0.90
46_F 50_G 1.005 0.90
247_N 253_R 1.005 0.90
13_T 17_V 1.001 0.89
114_S 270_K 1.001 0.89
240_L 271_K 1 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zuxA10.95481000.28Contact Map0.633
4bwzA10.945897.70.881Contact Map0.318
1zcdA20.936774.70.938Contact Map0.297
2kv5A10.09946.60.966Contact Map0.298
3w4tA10.95486.20.966Contact Map0.275
2kluA10.14465.70.967Contact Map0.12
4b19A10.09044.70.968Contact Map0.25
1q90M10.11754.10.969Contact Map0.395
2xutA30.59043.10.971Contact Map0.248
4he8L20.45182.80.971Contact Map0.329
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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