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OPENSEQ.org
NCPP - Non-canonical purine NTP phosphatase
UniProt: P39411 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12600
Length: 170 (170)
Sequences: 304
Seq/Len: 1.79
NCPP
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
113_K 118_E 2.227 0.99
15_Q 18_L 2.226 0.99
124_M 139_A 2.164 0.99
132_E 135_R 2.122 0.99
113_K 123_V 1.986 0.99
88_V 158_V 1.887 0.98
5_V 69_A 1.826 0.97
118_E 122_P 1.742 0.96
12_A 151_A 1.725 0.96
11_P 121_G 1.686 0.95
161_A 164_P 1.649 0.94
19_Q 151_A 1.631 0.94
42_P 50_E 1.624 0.94
124_M 133_I 1.605 0.93
97_G 165_F 1.578 0.92
35_V 62_A 1.575 0.92
145_A 167_N 1.547 0.91
130_I 142_V 1.54 0.91
6_C 32_I 1.515 0.90
149_T 152_S 1.51 0.90
113_K 126_R 1.508 0.90
21_F 162_L 1.48 0.89
42_P 47_G 1.475 0.88
84_T 104_L 1.413 0.85
41_V 57_N 1.406 0.85
37_V 61_N 1.402 0.85
121_G 135_R 1.397 0.84
11_P 135_R 1.377 0.83
48_S 87_W 1.376 0.83
118_E 123_V 1.375 0.83
134_G 154_Y 1.37 0.83
102_A 156_Q 1.365 0.82
20_A 162_L 1.332 0.80
128_T 142_V 1.322 0.80
39_S 57_N 1.319 0.79
63_R 72_W 1.309 0.79
86_S 157_A 1.303 0.78
110_I 127_Y 1.293 0.77
11_P 21_F 1.292 0.77
101_S 153_V 1.276 0.76
99_A 106_L 1.27 0.76
21_F 71_F 1.26 0.75
8_T 125_S 1.258 0.75
59_V 74_A 1.244 0.73
7_A 59_V 1.239 0.73
17_I 75_I 1.228 0.72
106_L 139_A 1.212 0.71
157_A 161_A 1.204 0.70
48_S 103_T 1.192 0.69
3_Q 31_H 1.191 0.69
20_A 159_I 1.19 0.69
108_A 115_R 1.178 0.68
43_E 122_P 1.168 0.67
145_A 166_H 1.165 0.66
125_S 130_I 1.151 0.65
119_A 125_S 1.149 0.65
18_L 93_A 1.144 0.64
8_T 12_A 1.134 0.63
77_A 140_I 1.131 0.63
99_A 153_V 1.11 0.61
14_I 140_I 1.109 0.61
56_R 60_A 1.097 0.59
19_Q 155_H 1.095 0.59
6_C 12_A 1.091 0.59
86_S 163_S 1.08 0.58
4_V 21_F 1.079 0.58
99_A 160_L 1.078 0.57
21_F 132_E 1.071 0.57
63_R 69_A 1.071 0.57
86_S 101_S 1.066 0.56
86_S 134_G 1.054 0.55
97_G 161_A 1.052 0.55
119_A 134_G 1.048 0.54
130_I 137_E 1.041 0.53
106_L 120_L 1.041 0.53
60_A 114_V 1.04 0.53
121_G 124_M 1.039 0.53
109_V 112_E 1.037 0.53
47_G 114_V 1.033 0.53
88_V 161_A 1.032 0.53
7_A 72_W 1.03 0.52
89_V 161_A 1.03 0.52
73_V 112_E 1.028 0.52
133_I 140_I 1.022 0.51
36_A 146_G 1.018 0.51
130_I 133_I 1.016 0.51
4_V 85_F 1.015 0.51
8_T 128_T 1.014 0.51
108_A 143_F 1.014 0.51
51_T 121_G 1.01 0.50
39_S 51_T 1.002 0.49
87_W 148_L 1.001 0.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1u14A111000.038Contact Map0.511
1zwyA411000.072Contact Map0.534
2carA20.717667.50.935Contact Map0.239
1k7kA10.747162.80.937Contact Map0.283
4bnqA20.735357.80.938Contact Map0.364
3tquA40.747157.50.939Contact Map0.301
3brcA20.664753.60.94Contact Map0.437
1b78A20.688247.30.942Contact Map0.244
1vp2A20.7176450.943Contact Map0.332
1v7rA10.682437.20.946Contact Map0.251
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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