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OPENSEQ.org
NANM - N-acetylneuraminate epimerase
UniProt: P39371 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12562
Length: 368 (325)
Sequences: 815
Seq/Len: 2.51
NANM
Paralog alert: 0.25 [within 20: 0.06] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
309_H 314_G 2.841 1.00
34_G 43_I 2.811 1.00
110_Y 115_N 2.765 1.00
192_F 197_Q 2.679 1.00
241_L 248_L 2.391 1.00
80_S 89_V 2.225 1.00
86_N 109_K 2.127 1.00
331_S 338_L 2.076 1.00
33_T 80_S 2.05 1.00
221_K 240_E 2.019 0.99
75_R 78_A 2.006 0.99
55_L 60_K 1.985 0.99
323_S 355_V 1.947 0.99
264_G 276_F 1.921 0.99
35_A 87_L 1.919 0.99
40_T 54_K 1.917 0.99
272_D 311_W 1.897 0.99
52_W 87_L 1.751 0.98
33_T 78_A 1.751 0.98
79_T 131_H 1.739 0.98
141_Y 189_L 1.714 0.98
42_Y 110_Y 1.663 0.97
261_G 328_Y 1.649 0.97
39_D 58_Q 1.647 0.97
141_Y 241_L 1.647 0.97
126_M 188_F 1.641 0.97
40_T 56_D 1.641 0.97
44_G 50_T 1.605 0.96
225_I 236_D 1.591 0.96
221_K 242_D 1.586 0.96
139_K 193_D 1.574 0.96
139_K 191_S 1.57 0.96
31_S 77_Q 1.551 0.95
203_G 248_L 1.529 0.95
211_A 261_G 1.493 0.94
126_M 129_A 1.491 0.94
223_W 238_V 1.477 0.93
220_D 244_T 1.456 0.93
35_A 80_S 1.456 0.93
86_N 111_N 1.444 0.92
131_H 140_A 1.441 0.92
107_V 140_A 1.425 0.92
141_Y 222_T 1.39 0.90
30_K 328_Y 1.366 0.89
263_A 329_G 1.362 0.89
78_A 129_A 1.362 0.89
223_W 240_E 1.354 0.89
43_I 64_W 1.349 0.88
29_F 45_L 1.344 0.88
213_A 224_L 1.338 0.88
77_Q 328_Y 1.331 0.87
71_P 108_H 1.318 0.87
45_L 210_T 1.316 0.87
211_A 228_E 1.31 0.86
223_W 309_H 1.302 0.86
191_S 202_A 1.293 0.85
32_G 330_V 1.288 0.85
108_H 143_T 1.287 0.85
259_P 262_V 1.279 0.84
130_G 213_A 1.277 0.84
35_A 82_F 1.267 0.84
277_A 323_S 1.261 0.83
138_G 195_S 1.254 0.83
228_E 327_A 1.237 0.82
223_W 314_G 1.236 0.82
120_L 192_F 1.234 0.81
64_W 199_W 1.216 0.80
123_H 206_P 1.209 0.80
76_D 327_A 1.206 0.79
34_G 330_V 1.205 0.79
31_S 327_A 1.2 0.79
116_S 312_H 1.2 0.79
213_A 262_V 1.196 0.79
36_I 57_T 1.193 0.78
85_G 112_P 1.188 0.78
77_Q 260_D 1.182 0.77
75_R 212_G 1.181 0.77
111_N 114_T 1.178 0.77
337_S 356_L 1.178 0.77
109_K 118_V 1.174 0.77
110_Y 223_W 1.16 0.76
326_R 353_D 1.15 0.75
93_I 128_M 1.147 0.74
216_V 274_L 1.142 0.74
331_S 340_I 1.14 0.74
31_S 262_V 1.136 0.73
218_K 274_L 1.135 0.73
172_N 180_A 1.134 0.73
42_Y 54_K 1.133 0.73
26_P 106_D 1.129 0.73
93_I 228_E 1.128 0.73
311_W 314_G 1.128 0.73
47_S 146_V 1.121 0.72
131_H 142_V 1.12 0.72
211_A 280_A 1.118 0.72
128_M 261_G 1.116 0.72
26_P 53_Y 1.112 0.71
39_D 57_T 1.112 0.71
93_I 280_A 1.111 0.71
55_L 354_S 1.107 0.71
252_K 314_G 1.105 0.70
75_R 106_D 1.104 0.70
281_G 300_L 1.102 0.70
142_V 222_T 1.101 0.70
85_G 113_K 1.098 0.70
123_H 210_T 1.094 0.69
308_I 319_S 1.091 0.69
51_A 78_A 1.088 0.69
169_D 172_N 1.085 0.68
285_S 288_N 1.084 0.68
170_K 174_H 1.083 0.68
256_V 316_W 1.083 0.68
42_Y 313_N 1.08 0.68
228_E 261_G 1.076 0.68
210_T 239_F 1.075 0.67
110_Y 192_F 1.074 0.67
214_A 264_G 1.073 0.67
90_F 188_F 1.073 0.67
262_V 329_G 1.072 0.67
332_L 339_L 1.071 0.67
239_F 355_V 1.07 0.67
94_G 104_F 1.067 0.67
81_A 140_A 1.067 0.67
57_T 249_K 1.065 0.66
174_H 178_K 1.062 0.66
83_I 222_T 1.061 0.66
91_G 226_N 1.059 0.66
111_N 308_I 1.056 0.65
174_H 177_D 1.053 0.65
264_G 268_G 1.051 0.65
328_Y 350_A 1.042 0.64
31_S 47_S 1.04 0.64
42_Y 87_L 1.04 0.64
80_S 87_L 1.037 0.63
88_Y 140_A 1.036 0.63
277_A 303_S 1.034 0.63
30_K 341_I 1.033 0.63
26_P 64_W 1.032 0.63
216_V 269_I 1.031 0.63
40_T 86_N 1.029 0.62
43_I 331_S 1.028 0.62
126_M 130_G 1.025 0.62
220_D 243_F 1.022 0.62
55_L 339_L 1.021 0.62
78_A 225_I 1.02 0.61
47_S 77_Q 1.017 0.61
193_D 242_D 1.017 0.61
60_K 209_G 1.014 0.61
47_S 328_Y 1.014 0.61
211_A 350_A 1.013 0.61
76_D 211_A 1.01 0.60
110_Y 277_A 1.01 0.60
130_G 215_V 1.007 0.60
293_K 296_A 1.003 0.60
261_G 327_A 1.002 0.59
70_F 312_H 1.001 0.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2uvkA20.9131000.345Contact Map0.501
2vpjA10.74731000.404Contact Map0.521
2xn4A20.75271000.405Contact Map0.557
1zgkA10.77991000.412Contact Map0.586
3ii7A10.74181000.416Contact Map0.54
4ascA10.73911000.435Contact Map0.522
2wozA10.76631000.436Contact Map0.499
2zwaA20.79891000.467Contact Map0.47
1k3iA10.84781000.494Contact Map0.317
3nolA10.627797.80.902Contact Map0.494
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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