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OPENSEQ.org
QUEG - Epoxyqueuosine reductase
UniProt: P39288 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12481
Length: 379 (369)
Sequences: 979
Seq/Len: 2.65
QUEG
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
285_S 288_K 4.019 1.00
17_W 20_E 3.243 1.00
165_N 172_F 2.732 1.00
146_R 162_L 2.694 1.00
244_Y 301_I 2.63 1.00
161_S 214_V 2.488 1.00
14_I 125_I 2.463 1.00
143_I 178_L 2.441 1.00
78_V 175_G 2.433 1.00
41_Q 45_D 2.301 1.00
200_M 208_I 2.274 1.00
102_S 173_F 2.226 1.00
130_V 180_D 2.205 1.00
197_V 201_T 2.199 1.00
76_I 179_V 2.182 1.00
243_I 313_A 2.161 1.00
317_A 348_Q 2.142 1.00
324_L 345_I 2.137 1.00
77_S 176_E 2.106 1.00
51_E 227_L 2.03 1.00
79_R 174_L 2.012 1.00
237_P 347_Q 2.012 1.00
15_K 28_I 1.968 0.99
235_L 238_L 1.96 0.99
73_L 182_P 1.944 0.99
282_F 314_L 1.916 0.99
311_A 327_L 1.891 0.99
202_I 252_I 1.882 0.99
28_I 74_R 1.871 0.99
21_L 121_L 1.847 0.99
303_H 307_L 1.822 0.99
168_A 172_F 1.773 0.98
25_Q 165_N 1.752 0.98
13_K 128_H 1.745 0.98
64_R 67_E 1.729 0.98
122_G 134_F 1.696 0.98
11_A 15_K 1.693 0.98
154_L 163_I 1.687 0.98
133_N 180_D 1.642 0.97
243_I 310_I 1.635 0.97
108_R 295_G 1.608 0.97
48_Y 213_T 1.594 0.96
18_G 26_V 1.575 0.96
26_V 78_V 1.549 0.96
218_R 235_L 1.544 0.96
40_L 55_M 1.543 0.96
42_A 46_K 1.536 0.95
137_F 141_A 1.517 0.95
301_I 305_R 1.504 0.95
75_V 178_L 1.492 0.94
283_A 326_A 1.475 0.94
146_R 212_Y 1.473 0.94
72_T 178_L 1.473 0.94
208_I 214_V 1.468 0.94
319_W 348_Q 1.465 0.94
338_D 342_A 1.444 0.93
255_W 258_Y 1.441 0.93
11_A 28_I 1.424 0.92
34_S 37_E 1.423 0.92
242_R 248_D 1.412 0.92
74_R 185_V 1.412 0.92
53_D 56_A 1.41 0.92
136_P 177_L 1.378 0.91
116_N 123_E 1.377 0.91
103_R 106_L 1.356 0.90
116_N 120_K 1.351 0.89
291_K 294_E 1.348 0.89
30_D 151_K 1.348 0.89
286_E 290_L 1.342 0.89
76_I 177_L 1.338 0.89
146_R 157_T 1.336 0.89
15_K 186_D 1.318 0.88
366_R 369_R 1.307 0.87
228_E 305_R 1.304 0.87
58_H 61_L 1.295 0.87
302_G 305_R 1.293 0.86
16_Q 19_L 1.291 0.86
361_L 365_Q 1.278 0.86
290_L 293_T 1.276 0.85
17_W 21_L 1.27 0.85
118_L 175_G 1.269 0.85
85_A 268_S 1.267 0.85
331_K 342_A 1.264 0.85
75_V 148_L 1.263 0.85
17_W 124_M 1.257 0.84
12_Q 16_Q 1.25 0.84
99_G 278_L 1.246 0.84
24_Q 81_N 1.243 0.83
159_K 200_M 1.233 0.83
189_V 192_G 1.227 0.82
191_E 212_Y 1.226 0.82
74_R 183_L 1.22 0.82
68_L 141_A 1.218 0.82
36_S 39_K 1.218 0.82
33_L 37_E 1.218 0.82
42_A 45_D 1.217 0.82
79_R 172_F 1.213 0.81
156_W 255_W 1.205 0.81
355_C 369_R 1.205 0.81
307_L 330_R 1.205 0.81
99_G 276_P 1.202 0.80
40_L 54_W 1.196 0.80
44_L 59_G 1.193 0.80
355_C 364_K 1.183 0.79
364_K 369_R 1.181 0.79
100_Y 106_L 1.17 0.78
24_Q 263_T 1.164 0.77
123_E 126_Q 1.158 0.77
48_Y 209_V 1.15 0.76
218_R 234_E 1.135 0.75
54_W 171_F 1.132 0.75
355_C 361_L 1.131 0.74
226_E 300_R 1.131 0.74
210_E 213_T 1.131 0.74
361_L 364_K 1.127 0.74
28_I 186_D 1.126 0.74
333_E 337_L 1.123 0.74
357_V 361_L 1.122 0.74
145_E 174_L 1.117 0.73
369_R 373_K 1.115 0.73
364_K 367_L 1.114 0.73
41_Q 60_M 1.111 0.73
156_W 192_G 1.11 0.73
98_L 277_E 1.109 0.72
371_I 374_G 1.107 0.72
123_E 127_Q 1.105 0.72
43_W 55_M 1.102 0.72
117_R 264_E 1.101 0.72
357_V 369_R 1.096 0.71
115_R 141_A 1.095 0.71
200_M 211_P 1.094 0.71
157_T 163_I 1.093 0.71
365_Q 369_R 1.093 0.71
146_R 163_I 1.086 0.70
172_F 264_E 1.083 0.70
356_I 361_L 1.08 0.70
312_V 340_H 1.079 0.69
223_L 235_L 1.079 0.69
356_I 367_L 1.074 0.69
50_G 227_L 1.066 0.68
230_A 339_E 1.065 0.68
290_L 299_R 1.065 0.68
99_G 277_E 1.065 0.68
29_T 148_L 1.059 0.67
310_I 314_L 1.056 0.67
11_A 186_D 1.053 0.67
209_V 215_D 1.052 0.67
314_L 323_I 1.048 0.66
161_S 213_T 1.045 0.66
244_Y 296_S 1.039 0.65
161_S 211_P 1.039 0.65
351_R 355_C 1.038 0.65
61_L 67_E 1.036 0.65
166_R 189_V 1.035 0.65
366_R 374_G 1.031 0.64
60_M 63_A 1.025 0.64
361_L 369_R 1.024 0.64
357_V 368_V 1.024 0.64
282_F 310_I 1.024 0.64
357_V 364_K 1.022 0.63
310_I 313_A 1.022 0.63
157_T 160_H 1.022 0.63
364_K 373_K 1.021 0.63
373_K 376_P 1.02 0.63
368_V 375_L 1.02 0.63
359_V 367_L 1.017 0.63
30_D 74_R 1.016 0.63
368_V 373_K 1.015 0.63
338_D 341_I 1.014 0.62
20_E 124_M 1.013 0.62
197_V 200_M 1.012 0.62
103_R 251_L 1.011 0.62
80_M 117_R 1.009 0.62
357_V 365_Q 1.007 0.62
355_C 367_L 1.006 0.62
361_L 373_K 1.005 0.61
325_T 328_E 1.005 0.61
314_L 327_L 1.005 0.61
355_C 365_Q 1.004 0.61
294_E 299_R 1.004 0.61
356_I 364_K 1.003 0.61
317_A 323_I 1.003 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2bs2B20.601699.30.899Contact Map0.109
3i9v920.453898.70.919Contact Map0.522
4jw2A10.261297.70.938Contact Map0.724
1jnrB20.364197.70.939Contact Map0.409
2v2kA20.258697.50.941Contact Map0.563
2zvsA30.208497.50.941Contact Map0.617
1bc6A10.184797.40.942Contact Map0.866
3gyxB60.34397.30.943Contact Map0.43
1h98A10.187397.20.944Contact Map0.602
7fd1A10.2639970.945Contact Map0.46
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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