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OPENSEQ.org
RSGA - Putative ribosome biogenesis GTPase RsgA
UniProt: P39286 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12479
Length: 350 (302)
Sequences: 1644
Seq/Len: 5.44
RSGA
Paralog alert: 0.10 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
80_V 101_H 3.352 1.00
43_I 78_R 3.209 1.00
323_E 327_E 3.116 1.00
154_E 186_R 2.971 1.00
314_E 318_E 2.885 1.00
80_V 99_A 2.838 1.00
82_R 98_E 2.668 1.00
125_Q 210_S 2.625 1.00
149_E 185_Y 2.617 1.00
303_K 306_T 2.506 1.00
298_K 309_G 2.45 1.00
126_I 148_C 2.382 1.00
127_V 156_I 2.367 1.00
125_Q 208_R 2.341 1.00
41_E 101_H 2.263 1.00
186_R 204_A 2.22 1.00
142_D 328_N 2.187 1.00
156_I 204_A 2.176 1.00
234_I 256_Y 2.147 1.00
64_C 95_G 2.112 1.00
240_S 243_S 2.089 1.00
191_S 222_S 2.087 1.00
142_D 180_Y 2.064 1.00
123_I 211_I 2.026 1.00
311_A 315_A 2.002 1.00
293_Y 321_I 1.995 1.00
42_G 54_V 1.988 1.00
305_D 330_H 1.986 1.00
55_E 257_H 1.965 1.00
124_D 208_R 1.92 1.00
178_D 181_R 1.916 1.00
194_T 197_G 1.895 1.00
160_N 192_S 1.891 1.00
120_A 265_I 1.873 1.00
127_V 212_F 1.872 1.00
104_T 124_D 1.829 1.00
293_Y 315_A 1.821 1.00
127_V 210_S 1.811 1.00
147_A 273_F 1.804 1.00
191_S 197_G 1.8 1.00
44_V 73_L 1.707 1.00
126_I 211_I 1.706 1.00
225_N 236_T 1.704 1.00
212_F 264_V 1.665 1.00
313_R 317_E 1.662 1.00
224_L 264_V 1.662 1.00
257_H 263_D 1.652 0.99
141_I 157_I 1.611 0.99
125_Q 156_I 1.594 0.99
125_Q 205_L 1.575 0.99
53_D 63_R 1.562 0.99
132_I 159_L 1.559 0.99
126_I 153_I 1.552 0.99
41_E 80_V 1.551 0.99
150_T 282_Q 1.545 0.99
316_V 326_F 1.52 0.99
278_L 283_I 1.516 0.99
42_G 64_C 1.498 0.99
52_A 97_V 1.463 0.98
56_S 81_W 1.451 0.98
131_A 136_L 1.451 0.98
81_W 95_G 1.43 0.98
127_V 201_L 1.411 0.98
326_F 330_H 1.405 0.98
228_L 259_P 1.402 0.98
158_V 201_L 1.4 0.98
46_S 254_R 1.396 0.98
289_E 321_I 1.389 0.98
127_V 158_V 1.382 0.98
131_A 239_I 1.361 0.97
305_D 333_L 1.35 0.97
259_P 262_G 1.348 0.97
228_L 231_Q 1.348 0.97
62_H 81_W 1.347 0.97
290_F 294_L 1.335 0.97
133_L 244_G 1.327 0.97
231_Q 234_I 1.326 0.97
178_D 182_N 1.305 0.96
130_S 141_I 1.283 0.96
79_V 97_V 1.278 0.96
195_Q 198_L 1.274 0.96
192_S 222_S 1.271 0.95
177_M 181_R 1.269 0.95
293_Y 311_A 1.261 0.95
200_P 203_E 1.26 0.95
141_I 176_Q 1.251 0.95
139_N 328_N 1.246 0.95
190_V 222_S 1.238 0.95
199_K 202_E 1.237 0.95
303_K 333_L 1.234 0.94
139_N 143_R 1.231 0.94
154_E 208_R 1.221 0.94
296_L 311_A 1.22 0.94
43_I 209_I 1.219 0.94
128_I 213_A 1.217 0.94
140_I 215_Q 1.216 0.94
41_E 78_R 1.201 0.93
197_G 200_P 1.196 0.93
111_D 253_A 1.193 0.93
78_R 104_T 1.189 0.93
234_I 252_A 1.172 0.92
162_I 189_M 1.153 0.91
128_I 155_P 1.152 0.91
108_T 116_V 1.141 0.91
188_L 204_A 1.131 0.90
195_Q 226_A 1.122 0.90
307_D 329_Y 1.117 0.90
314_E 317_E 1.115 0.89
279_E 282_Q 1.115 0.89
177_M 189_M 1.114 0.89
166_D 169_G 1.112 0.89
225_N 234_I 1.108 0.89
42_G 185_Y 1.106 0.89
203_E 206_T 1.1 0.89
46_S 53_D 1.088 0.88
107_L 153_I 1.086 0.88
143_R 335_S 1.086 0.88
172_F 175_E 1.085 0.88
110_P 113_Y 1.085 0.88
141_I 328_N 1.083 0.87
239_I 243_S 1.08 0.87
136_L 215_Q 1.077 0.87
293_Y 320_K 1.07 0.87
283_I 336_M 1.063 0.86
67_R 96_I 1.062 0.86
160_N 191_S 1.059 0.86
125_Q 154_E 1.058 0.86
253_A 265_I 1.055 0.86
222_S 236_T 1.054 0.86
46_S 252_A 1.049 0.85
143_R 225_N 1.038 0.84
205_L 210_S 1.036 0.84
149_E 291_H 1.035 0.84
143_R 248_H 1.023 0.83
199_K 203_E 1.019 0.83
105_S 119_I 1.019 0.83
119_I 270_V 1.018 0.83
105_S 124_D 1.017 0.83
149_E 288_V 1.013 0.82
52_A 68_R 1.006 0.82
236_T 252_A 1.005 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2rcnA10.99141000.282Contact Map0.751
1t9hA10.85141000.402Contact Map0.73
1u0lA30.84291000.406Contact Map0.773
2yv5A10.84571000.418Contact Map0.678
3cnlA10.631499.90.801Contact Map0.479
1pujA10.6499.90.802Contact Map0.597
3ec1A20.754399.90.805Contact Map0.524
3h2yA10.768699.90.807Contact Map0.529
4dcuA10.8499.60.853Contact Map0.369
1mkyA10.811499.60.855Contact Map0.405
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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