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OPENSEQ.org
CYSJ - Sulfite reductase [NADPH] flavoprotein alpha-component
UniProt: P38038 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10191
Length: 599 (562)
Sequences: 1443
Seq/Len: 2.57
CYSJ
Paralog alert: 0.18 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
458_I 549_I 5.134 1.00
152_S 165_G 4.17 1.00
391_A 404_T 3.479 1.00
533_R 568_E 3.454 1.00
536_G 573_F 3.41 1.00
169_D 179_R 3.407 1.00
71_Q 126_E 3.243 1.00
171_K 175_L 3.029 1.00
532_L 569_V 2.994 1.00
577_D 580_A 2.962 1.00
244_N 257_R 2.96 1.00
532_L 539_L 2.942 1.00
551_V 594_Y 2.76 1.00
147_A 178_E 2.68 1.00
171_K 174_E 2.653 1.00
492_F 521_D 2.574 1.00
148_F 173_A 2.416 1.00
515_D 535_Q 2.405 1.00
531_K 534_E 2.337 1.00
76_R 80_E 2.322 1.00
541_R 545_D 2.308 1.00
166_K 185_D 2.281 1.00
542_W 547_A 2.262 1.00
499_Q 503_Q 2.247 1.00
496_F 518_W 2.243 1.00
113_I 201_V 2.14 1.00
329_V 363_M 2.126 1.00
101_Y 109_E 2.105 1.00
173_A 179_R 2.102 1.00
86_L 202_V 2.074 1.00
471_M 502_W 2.067 1.00
246_K 255_D 2.059 1.00
464_I 502_W 2.041 1.00
558_M 562_V 2.034 1.00
277_G 387_L 2.033 1.00
260_E 402_H 2.017 0.99
492_F 499_Q 2.006 0.99
151_F 186_A 1.982 0.99
559_A 598_V 1.973 0.99
291_V 298_G 1.973 0.99
502_W 514_I 1.968 0.99
587_E 591_E 1.968 0.99
530_D 533_R 1.945 0.99
277_G 438_F 1.939 0.99
404_T 498_Y 1.912 0.99
522_Q 526_V 1.907 0.99
151_F 194_A 1.906 0.99
70_S 127_E 1.863 0.99
447_L 455_V 1.846 0.99
288_K 312_N 1.831 0.99
530_D 561_D 1.817 0.99
64_I 86_L 1.806 0.99
496_F 516_L 1.803 0.99
541_R 544_N 1.803 0.99
354_Y 366_F 1.8 0.99
289_E 365_R 1.789 0.98
239_A 437_V 1.788 0.98
69_A 128_A 1.781 0.98
536_G 572_E 1.757 0.98
341_L 344_L 1.734 0.98
571_A 578_T 1.712 0.98
467_F 470_F 1.7 0.98
383_L 420_G 1.687 0.98
276_L 437_V 1.683 0.98
391_A 498_Y 1.664 0.97
313_E 317_W 1.645 0.97
537_A 573_F 1.645 0.97
457_M 467_F 1.639 0.97
116_T 168_F 1.616 0.97
540_W 570_I 1.616 0.97
163_Q 167_D 1.614 0.97
430_E 433_G 1.609 0.96
290_L 321_L 1.603 0.96
70_S 75_A 1.595 0.96
533_R 565_A 1.588 0.96
472_Q 501_E 1.584 0.96
251_N 494_E 1.583 0.96
554_D 559_A 1.578 0.96
117_S 125_P 1.577 0.96
460_P 467_F 1.575 0.96
520_R 527_Y 1.565 0.96
451_P 477_D 1.558 0.96
526_V 531_K 1.553 0.95
504_R 508_D 1.551 0.95
405_V 422_S 1.549 0.95
67_I 98_A 1.548 0.95
83_R 95_L 1.548 0.95
456_I 547_A 1.545 0.95
486_F 535_Q 1.54 0.95
397_V 402_H 1.521 0.95
468_R 501_E 1.469 0.93
424_F 436_R 1.463 0.93
580_A 583_E 1.451 0.93
263_L 401_V 1.447 0.93
258_H 402_H 1.442 0.93
513_R 535_Q 1.427 0.92
539_L 569_V 1.426 0.92
181_L 200_R 1.423 0.92
429_V 433_G 1.423 0.92
116_T 125_P 1.419 0.92
535_Q 538_E 1.413 0.91
162_C 165_G 1.413 0.91
538_E 541_R 1.413 0.91
69_A 116_T 1.41 0.91
312_N 316_Q 1.401 0.91
393_S 473_Q 1.397 0.91
248_T 256_V 1.397 0.91
570_I 585_L 1.39 0.91
554_D 557_R 1.389 0.91
491_H 494_E 1.386 0.90
112_L 146_T 1.381 0.90
473_Q 477_D 1.373 0.90
143_L 177_G 1.37 0.90
549_I 566_L 1.364 0.89
540_W 574_G 1.363 0.89
273_G 389_S 1.357 0.89
148_F 169_D 1.355 0.89
145_N 178_E 1.345 0.89
567_L 582_D 1.343 0.88
124_P 164_S 1.339 0.88
503_Q 507_K 1.335 0.88
515_D 538_E 1.334 0.88
261_I 437_V 1.334 0.88
82_L 115_V 1.326 0.88
148_F 177_G 1.322 0.87
486_F 539_L 1.32 0.87
563_E 585_L 1.316 0.87
98_A 131_L 1.313 0.87
256_V 497_L 1.31 0.87
150_V 165_G 1.303 0.86
185_D 188_V 1.301 0.86
258_H 498_Y 1.297 0.86
583_E 587_E 1.293 0.86
486_F 531_K 1.292 0.86
275_A 387_L 1.291 0.86
533_R 536_G 1.29 0.86
570_I 576_M 1.288 0.86
240_S 432_E 1.287 0.85
114_V 168_F 1.282 0.85
276_L 439_I 1.273 0.85
537_A 541_R 1.273 0.85
496_F 503_Q 1.271 0.85
315_L 319_F 1.268 0.84
354_Y 358_T 1.268 0.84
85_D 198_R 1.265 0.84
65_T 112_L 1.263 0.84
341_L 345_V 1.258 0.84
151_F 184_V 1.253 0.83
374_E 378_N 1.252 0.83
166_K 183_R 1.248 0.83
69_A 98_A 1.248 0.83
78_V 115_V 1.243 0.83
132_H 168_F 1.241 0.83
147_A 180_L 1.24 0.82
486_F 515_D 1.227 0.82
201_V 205_L 1.224 0.81
149_A 180_L 1.219 0.81
260_E 498_Y 1.218 0.81
500_V 503_Q 1.218 0.81
397_V 472_Q 1.209 0.80
118_T 165_G 1.205 0.80
450_N 453_T 1.203 0.80
576_M 581_A 1.203 0.80
78_V 194_A 1.201 0.80
82_L 198_R 1.198 0.79
128_A 552_C 1.197 0.79
66_I 95_L 1.194 0.79
118_T 162_C 1.193 0.79
132_H 167_D 1.191 0.79
386_R 389_S 1.186 0.78
263_L 267_G 1.186 0.78
567_L 581_A 1.186 0.78
260_E 400_E 1.183 0.78
182_D 200_R 1.183 0.78
170_S 174_E 1.18 0.78
418_A 423_S 1.18 0.78
238_V 434_E 1.18 0.78
404_T 468_R 1.18 0.78
527_Y 558_M 1.177 0.78
387_L 440_E 1.176 0.78
288_K 292_E 1.171 0.77
290_L 315_L 1.168 0.77
281_Q 317_W 1.166 0.77
237_L 266_S 1.165 0.77
475_A 505_Y 1.162 0.76
76_R 127_E 1.161 0.76
460_P 554_D 1.16 0.76
67_I 112_L 1.157 0.76
515_D 531_K 1.156 0.76
554_D 597_D 1.154 0.76
517_A 525_K 1.147 0.75
491_H 521_D 1.146 0.75
287_V 316_Q 1.146 0.75
163_Q 166_K 1.139 0.74
514_I 518_W 1.133 0.74
98_A 127_E 1.13 0.74
71_Q 75_A 1.117 0.72
335_L 372_D 1.114 0.72
270_Y 392_S 1.111 0.72
484_W 539_L 1.106 0.71
358_T 366_F 1.105 0.71
69_A 127_E 1.104 0.71
284_P 316_Q 1.102 0.71
474_R 481_G 1.098 0.70
283_D 428_R 1.097 0.70
339_E 342_L 1.097 0.70
67_I 101_Y 1.095 0.70
289_E 293_L 1.092 0.70
261_I 435_V 1.092 0.70
457_M 483_N 1.091 0.70
484_W 542_W 1.089 0.70
482_K 545_D 1.088 0.69
74_N 190_Y 1.084 0.69
172_L 177_G 1.082 0.69
389_S 597_D 1.082 0.69
152_S 162_C 1.077 0.68
328_I 360_I 1.075 0.68
242_S 400_E 1.07 0.68
299_D 312_N 1.07 0.68
594_Y 597_D 1.069 0.68
101_Y 134_F 1.066 0.67
475_A 508_D 1.062 0.67
333_A 342_L 1.061 0.67
120_G 123_E 1.061 0.67
276_L 401_V 1.054 0.66
248_T 255_D 1.05 0.65
457_M 549_I 1.049 0.65
372_D 375_A 1.049 0.65
66_I 82_L 1.047 0.65
576_M 584_F 1.044 0.65
158_Y 162_C 1.043 0.65
232_S 235_A 1.043 0.65
69_A 86_L 1.04 0.64
447_L 470_F 1.039 0.64
496_F 517_A 1.038 0.64
565_A 568_E 1.037 0.64
482_K 538_E 1.034 0.64
518_W 521_D 1.033 0.64
114_V 172_L 1.033 0.64
484_W 515_D 1.033 0.64
67_I 114_V 1.028 0.63
231_Y 236_P 1.025 0.63
82_L 113_I 1.023 0.63
533_R 572_E 1.023 0.63
319_F 377_I 1.019 0.62
283_D 296_L 1.018 0.62
584_F 593_R 1.017 0.62
335_L 375_A 1.017 0.62
66_I 83_R 1.014 0.62
456_I 539_L 1.013 0.61
455_V 483_N 1.012 0.61
549_I 588_L 1.012 0.61
150_V 177_G 1.012 0.61
559_A 597_D 1.01 0.61
407_V 423_S 1.007 0.61
254_K 275_A 1.007 0.61
460_P 558_M 1.006 0.61
97_N 119_Q 1.001 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2bpoA20.96661000.316Contact Map0.712
3qe2A20.92151000.323Contact Map0.789
1tllA20.91151000.327Contact Map0.76
1ddgA20.62441000.49Contact Map0.806
1f20A10.65281000.504Contact Map0.735
3qfsA10.70451000.511Contact Map0.767
2qtlA10.76131000.516Contact Map0.7
4dqlA20.60771000.536Contact Map0.696
2bmwA10.47251000.767Contact Map0.655
2b5oA20.6061000.771Contact Map0.69
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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