May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
CHBG - UPF0249 protein ChbG
UniProt: P37794 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12198
Length: 249 (247)
Sequences: 489
Seq/Len: 1.98
CHBG
Paralog alert: 0.08 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
105_V 144_E 4.161 1.00
101_T 140_R 2.83 1.00
8_N 35_T 2.096 0.99
38_V 111_F 2.016 0.99
45_H 49_L 1.993 0.99
180_E 229_S 1.952 0.99
101_T 105_V 1.916 0.98
5_L 243_L 1.908 0.98
8_N 33_S 1.851 0.98
150_R 199_E 1.814 0.98
8_N 199_E 1.811 0.98
244_G 248_D 1.81 0.98
108_Y 141_F 1.809 0.98
62_F 104_L 1.788 0.97
73_M 77_T 1.769 0.97
234_G 238_Q 1.747 0.97
75_G 99_E 1.742 0.97
7_V 30_I 1.741 0.97
23_I 49_L 1.721 0.96
39_N 67_G 1.706 0.96
32_T 243_L 1.706 0.96
37_L 40_G 1.689 0.96
108_Y 112_I 1.667 0.95
111_F 119_P 1.633 0.95
8_N 121_H 1.632 0.95
25_A 224_L 1.622 0.95
26_C 56_L 1.607 0.94
16_K 45_H 1.597 0.94
237_A 241_Y 1.583 0.94
9_A 204_P 1.581 0.94
109_L 145_Q 1.567 0.93
105_V 109_L 1.545 0.92
169_F 201_M 1.545 0.92
19_N 45_H 1.541 0.92
24_E 28_N 1.532 0.92
129_H 150_R 1.49 0.91
100_I 104_L 1.482 0.90
37_L 63_V 1.458 0.89
57_A 120_T 1.449 0.89
188_D 239_R 1.449 0.89
9_A 22_I 1.442 0.89
8_N 123_D 1.441 0.89
108_Y 145_Q 1.426 0.88
12_F 199_E 1.416 0.87
141_F 145_Q 1.409 0.87
73_M 76_L 1.385 0.86
127_H 201_M 1.383 0.86
35_T 123_D 1.369 0.85
112_I 145_Q 1.343 0.83
104_L 124_S 1.341 0.83
21_G 224_L 1.328 0.82
7_V 232_L 1.32 0.82
18_Q 205_A 1.305 0.81
36_A 117_R 1.299 0.80
39_N 63_V 1.287 0.80
33_S 121_H 1.284 0.79
180_E 184_L 1.283 0.79
33_S 123_D 1.276 0.79
38_V 60_M 1.276 0.79
38_V 43_I 1.274 0.79
109_L 229_S 1.268 0.78
35_T 121_H 1.264 0.78
26_C 55_S 1.242 0.76
100_I 134_I 1.232 0.75
35_T 199_E 1.228 0.75
233_K 236_I 1.224 0.75
127_H 223_E 1.222 0.74
111_F 115_F 1.216 0.74
6_I 19_N 1.214 0.74
5_L 187_L 1.2 0.73
237_A 240_G 1.198 0.72
111_F 117_R 1.198 0.72
51_R 235_A 1.192 0.72
121_H 199_E 1.187 0.71
202_C 227_L 1.185 0.71
8_N 246_Y 1.182 0.71
8_N 150_R 1.178 0.71
235_A 239_R 1.174 0.70
67_G 82_L 1.171 0.70
10_D 13_G 1.163 0.69
74_P 240_G 1.158 0.69
15_S 19_N 1.15 0.68
223_E 227_L 1.147 0.68
104_L 141_F 1.139 0.67
63_V 111_F 1.133 0.66
127_H 150_R 1.133 0.66
12_F 150_R 1.131 0.66
71_T 106_S 1.13 0.66
17_G 210_T 1.113 0.64
126_H 216_Y 1.111 0.64
34_T 56_L 1.11 0.64
103_E 106_S 1.109 0.64
62_F 108_Y 1.099 0.63
5_L 166_T 1.087 0.61
120_T 123_D 1.086 0.61
109_L 112_I 1.084 0.61
150_R 204_P 1.084 0.61
36_A 46_A 1.074 0.60
23_I 53_E 1.072 0.60
62_F 141_F 1.07 0.60
26_C 54_P 1.066 0.59
108_Y 122_L 1.062 0.59
25_A 30_I 1.053 0.58
12_F 42_A 1.053 0.58
82_L 215_A 1.051 0.58
65_T 126_H 1.047 0.57
126_H 214_S 1.046 0.57
113_E 118_K 1.041 0.57
75_G 96_P 1.041 0.57
15_S 22_I 1.033 0.56
137_I 141_F 1.032 0.56
201_M 223_E 1.032 0.56
71_T 147_I 1.031 0.55
23_I 45_H 1.012 0.53
35_T 142_A 1.011 0.53
12_F 19_N 1.007 0.53
150_R 201_M 1.006 0.53
60_M 122_L 1.006 0.53
9_A 31_V 1.003 0.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i5iA20.97991000.095Contact Map0.67
2e67A60.90761000.186Contact Map0.589
2nlyA10.835397.10.899Contact Map0.523
2qv5A20.823396.40.908Contact Map0.449
2vyoA10.734995.70.913Contact Map0.385
1v6tA10.863593.90.921Contact Map0.551
2dfaA10.851493.20.924Contact Map0.534
1xw8A10.863593.10.924Contact Map0.574
1ny1A20.73992.50.925Contact Map0.361
2j13A10.730991.30.928Contact Map0.44
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0157 seconds.